Scientist I, Ophthalmology Research

Astellas Pharma; Westborough (MA); On-site; USD 95,000 - 135,000; Full time

Benefits offered by this job

Medical, Dental, and Vision Insurance

401(k) match and company contribution

Company paid life insurance

Annual Corporate Bonus and Incentives

Job summary

Astellas Pharma in Westborough, MA seeks a researcher for ophthalmology-focused in vivo studies. The role involves hands-on dosing, data collection, and collaboration within a multidisciplinary team.

Candidates bring advanced degrees and experience in ophthalmology, retinal biology, or related fields. This on-site position emphasizes rigorous documentation, results sharing, and continuous learning in a dynamic environment.

Qualifications

• PhD in ophthalmology, neuroscience, biology, pharmacology, or related field with 0–3 years experience.
• MS with 5+ years of relevant research experience.
• BS with 8+ years of relevant research experience.
• Hands‑on in vivo research and data analysis.
• Experience with animal models (rat/mouse) and lab techniques.
• Research in ophthalmology drug discovery or retinal biology.

Responsibilities

• Conduct in vivo ophthalmology pharmacology studies to evaluate candidates.
• Perform animal procedures including intraocular dosing and assessments.
• Analyze, document, and present experimental data with senior scientists.
• Contribute to study design, protocols, troubleshooting, and execution.
• Collaborate with CROs and internal teams; maintain records per standards.
• Communicate results via presentations and reports.

Skills

In vivo pharmacology

Animal models

Ophthalmology drug discovery

Data analysis

Collaborative teamwork

Scientific communication

Education

PhD in related field

MS with 5+ years experience

BS with 8+ years experience

Tools

Intraocular dosing techniques

Ocular imaging

Histology & tissue processing

ERG / visual function assessments

Job description

About Astellas

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.

Are you driven to make a real difference in the lives of patients?

We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.

Purpose & Scope

The Scientist I, Ophthalmology Research supports the design, execution, and analysis of in vivo ophthalmology research studies that advance therapeutic programs from discovery through early development. The incumbent will generate high-quality data through hands‑on laboratory work and collaborate within the broader research team to support program objectives. This is a bench‑based role that provides opportunities to develop scientific and technical expertise in ophthalmology research and drug discovery.

Role And Responsibilities

• Conduct in vivo pharmacology studies to evaluate therapeutic candidates across ophthalmology indications.
• Perform hands‑on experimental activities including animal procedures such as intraocular dosing (e.g. subretinal/intravitreal injection), clinical assessments, functional/efficacy evaluation, tissue collection, and other study‑related techniques.
• Analyze, interpret, document, and present experimental data with guidance from senior scientists.
• Contribute to study design, protocol development, troubleshooting, and execution of research plans.
• Assist with internally and externally conducted studies, including collaborations with cross‑functional teams and contract research organizations.
• Maintain accurate laboratory records, notebooks, and study documentation in accordance with company standards.
• Communicate scientific results through presentations, reports, and team discussions.
• Contribute to a collaborative, inclusive, and scientifically rigorous work environment by sharing knowledge and working effectively with team members.
• Remain current with relevant scientific literature, technologies, and emerging approaches in ophthalmology research and drug discovery.

Required Qualifications

• PhD in Ophthalmology, Neuroscience, Biology, Pharmacology, or a related scientific discipline with 0-3 years of relevant postdoctoral and/or industry research experience; OR
• MS degree with 5+ years of relevant research experience; OR
• BS degree with 8+ years of relevant research experience.
• Hands‑on experience conducting in vivo research studies and analyzing experimental data.
• Experience working with animal models (rat and/or mouse) and laboratory research techniques.
• Research experience in ophthalmology drug discovery, retinal biology, or related disciplines.
• Familiarity with one or more therapeutic modalities, including biologics, gene therapy, cell therapy, RNA therapeutics, or small molecules.
• Strong organizational skills, attention to detail, and ability to maintain accurate documentation.
• Demonstrated ability to work effectively in a collaborative team environment.
• Strong written, verbal, and presentation communication skills.

Preferred Qualifications

• Intraocular dosing techniques in rodents (i.e. subretinal injection, intravitreal injection, etc.)
• Experience with ocular imaging and visual function assessments, including OCT, fundus imaging, ERG, optomotor response, or related techniques.
• Experience with ocular histology, tissue processing, microscopy, and image analysis.
• Familiarity with translational research and drug discovery.
• Experience collaborating with external laboratories, CROs, or academic partners.
• Demonstrated ability to learn new techniques and adapt to changing project priorities.

Location and Working Environment

• This position is based in Westborough, MA and requires on‑site work.
• The incumbent is expected to actively participate in experimental design, study execution, data analysis, and scientific discussions.
• The role involves collaboration with internal and external stakeholders in a highly collaborative research environment.

What awaits you at Astellas?

• Global collaboration: Become part of a connected global business of like‑minded life science leaders, all dedicated to improving patients' lives worldwide.
• Real‑world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.
• Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.
• A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions.

Our Organizational Values and Behaviors

Values: Innovation, Integrity and Impact sit at the heart of what we do.

Behaviors: We come together as ‘One Astellas’, working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.

Salary Range

$94,570 - $135,100 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)

Benefits

• Medical, Dental and Vision Insurance
• Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year‑end shut down
• 401(k) match and annual company contribution
• Company paid life insurance
• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
• Long Term Incentive Plan for eligible positions
• Company fleet vehicle for eligible positions
• Referral bonus program

Category Biology

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans