Scientist I, Ophthalmology Research

Astellas; Westborough (MA); On-site; USD 95,000 - 135,000; Full time

Benefits offered by this job

Medical, Dental and Vision Insurance

401(k) match and annual company match

Annual Corporate Bonus

Job summary

Astellas is seeking a Scientist I, Ophthalmology Research, based in Westborough, MA. This bench-based role supports design, execution, and analysis of in vivo ophthalmology studies that advance programs from discovery through early development.

You will generate high-quality data, operate under company standards, and collaborate with the broader research team to meet program objectives. A strong emphasis on rigorous data handling and scientific communication is required.

Qualifications

• PhD in Ophthalmology, Neuroscience, Biology, Pharmacology, or related field with 0–3 years postdoc/industry experience; OR
• MS with 5+ years relevant research experience; OR
• BS with 8+ years relevant research experience.

Responsibilities

• Conduct in vivo pharmacology studies across ophthalmology indications.
• Perform animal procedures including intraocular dosing (subretinal/intravitreal) and tissue collection.
• Analyze and present experimental data with senior scientist guidance.
• Contribute to study design and protocol development.
• Collaborate with cross-functional teams and CROs.

Skills

In vivo pharmacology

Animal models

Data analysis

Education

PhD in Ophthalmology/Neuroscience/Biology/Pharmacology

MS with 5+ years of relevant research

BS with 8+ years of relevant research

Tools

OCT

Fundus imaging

ERG

Histology

Microscopy

Job description

Westborough, Massachusetts, United States

Job Description

Scientist I, Ophthalmology Research

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.

Are you driven to make a real difference in the lives of patients?

We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.

Purpose & Scope

The Scientist I, Ophthalmology Research supports the design, execution, and analysis of in vivo ophthalmology research studies that advance therapeutic programs from discovery through early development. The incumbent will generate high-quality data through hands-on laboratory work and collaborate within the broader research team to support program objectives. This is a bench-based role that provides opportunities to develop scientific and technical expertise in ophthalmology research and drug discovery.

Role and Responsibilities

• Conduct in vivo pharmacology studies to evaluate therapeutic candidates across ophthalmology indications.
• Perform hands-on experimental activities including animal procedures such as intraocular dosing (e.g. subretinal/intravitreal injection), clinical assessments, functional/efficacy evaluation, tissue collection, and other study-related techniques.
• Analyze, interpret, document, and present experimental data with guidance from senior scientists.
• Contribute to study design, protocol development, troubleshooting, and execution of research plans.
• Assist with internally and externally conducted studies, including collaborations with cross-functional teams and contract research organizations.
• Maintain accurate laboratory records, notebooks, and study documentation in accordance with company standards.
• Communicate scientific results through presentations, reports, and team discussions.
• Contribute to a collaborative, inclusive, and scientifically rigorous work environment by sharing knowledge and working effectively with team members.
• Remain current with relevant scientific literature, technologies, and emerging approaches in ophthalmology research and drug discovery.

Location(s)

Westborough , Massachusetts , United States

Requirements

Required Qualifications

• PhD in Ophthalmology, Neuroscience, Biology, Pharmacology, or a related scientific discipline with 0-3 years of relevant postdoctoral and/or industry research experience; OR
• MS degree with 5+ years of relevant research experience; OR
• BS degree with 8+ years of relevant research experience.
• Hands-on experience conducting in vivo research studies and analyzing experimental data.
• Experience working with animal models (rat and/or mouse) and laboratory research techniques.
• Research experience in ophthalmology drug discovery, retinal biology, or related disciplines.
• Familiarity with one or more therapeutic modalities, including biologics, gene therapy, cell therapy, RNA therapeutics, or small molecules.
• Strong organizational skills, attention to detail, and ability to maintain accurate documentation.
• Demonstrated ability to work effectively in a collaborative team environment.
• Strong written, verbal, and presentation communication skills.

Preferred Qualifications

• Intraocular dosing techniques in rodents (i.e. subretinal injection, intravitreal injection, etc.)
• Experience with ocular imaging and visual function assessments, including OCT, fundus imaging, ERG, optomotor response, or related techniques.
• Experience with ocular histology, tissue processing, microscopy, and image analysis.
• Familiarity with translational research and drug discovery.
• Experience collaborating with external laboratories, CROs, or academic partners.
• Demonstrated ability to learn new techniques and adapt to changing project priorities.

Location and Working Environment

• This position is based in Westborough, MA and requires on-site work.
• The incumbent is expected to actively participate in experimental design, study execution, data analysis, and scientific discussions.
• The role involves collaboration with internal and external stakeholders in a highly collaborative research environment.

What awaits you at Astellas?

• Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide.
• Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.
• Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.
• A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions.

Our Organizational Values and Behaviors

Values: Innovation, Integrity and Impact sit at the heart of what we do.

Behaviors: We come together as ‘One Astellas’, working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.

Salary Range

$94,570 - $135,100 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)

• Medical, Dental and Vision Insurance
• Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
• 401(k) match and annual company contribution
• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
• Long Term Incentive Plan for eligible positions
• Company fleet vehicle for eligible positions

Our organization is committed to diversity, equal opportunity, and affirmative action. We are an equal opportunity employer. All applicants will be considered without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity, or any other protected characteristic.

EEO is the Law

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