Scientist I/II, Modality Engineering

Lexeo Therapeutics; New York (NY); In loco; USD 111.000 - 150.000; Tempo pieno

Descrizione del lavoro

Lexeo Therapeutics is hiring a hands-on Modality Engineering Scientist in New York City to design, synthesize, and characterize oligonucleotides, bioconjugates, and AAV therapeutics for the discovery pipeline. The role spans chemistry, molecular biology, and pharmacology, with handoff to in vitro and in vivo teams.

The candidate will manage CROs, optimize conjugates, engineer AAVs, and collaborate across disciplines to advance molecules, write SOPs, and contribute to IP and regulatory filings.

Competenze

• PhD or MS with substantial hands-on industry experience in oligonucleotide or bioconjugate work must be shown.
• Experience synthesizing, purifying, and characterizing ASOs/siRNAs or related bioconjugates.
• Strong publication, patent, or technical contributions demonstrating productivity.

Mansioni

• Select and manage CROs for oligonucleotide synthesis and bioconjugation.
• Design and oversee oligonucleotide conjugates; optimize conjugation chemistry and analytics.
• Engineer AAV capsids and regulatory elements; conduct cloning and vector production.
• Design and screen sequences with NGS readouts; apply analytical methods to improve potency and yield.
• Collaborate with In Vitro/In Vivo teams to define cascades and support go/no-go decisions.
• Support process development and formulation; identify risks and propose experiments.
• Write SOPs, document work in ELN, present results, and monitor platform advances.

Conoscenze

Oligonucleotide synthesis

Purification & characterization

Analytical methods (HPLC, LC-MS)

Cross-disciplinary collaboration

Scientific writing & IP documentation

Formazione

PhD in chemistry/bi chemical biology/molecular biology (0–3 yrs postdoc)

MS with 5+ years industry experience

Strumenti

HPLC

LC-MS

SDS-PAGE

Descrizione del lavoro

Role Summary

Lexeo is hiring a hands-on Modality Engineering Scientist to design, synthesize, and characterize oligonucleotides, bioconjugates, and AAV therapeutics for our discovery pipeline. The scientist will advance molecules from design through analytical characterization and handoff to in vitro and in vivo teams, working across chemistry, molecular biology, and pharmacology. Reporting to the Head of Cardiac Research, this role joins cardiac, neuroscience, and non-clinical scientists developing therapies for genetic heart disease and offers broad experience in multidisciplinary biopharma research.

Primary Responsibilities

• Select and manage CROs for oligonucleotide synthesis and bioconjugation, including scope, vendor guidance, data review, quality, and delivery timelines
• Design and oversee oligonucleotide conjugates using peptides, antibodies, or ligands; optimize conjugation chemistry, linkers, purification, and analytical characterization
• Build or outsource methods to confirm identity and assess purity using HPLC, LC-MS, SDS-PAGE, spectroscopy, and other fit-for-purpose assays
• Engineer AAV capsids, regulatory elements, and transgene cassettes; conduct cloning, plasmid preparation, sequencing, and research-grade vector production
• Design and screen sequence or vector/capsid with NGS readouts, applying state-of-the-art analytical methods to improve potency, selectivity, and production yield
• Partner with In Vitro Pharmacology, In Vivo Physiology, Analytical DMPK, and CMC to define screening cascades, interpret data, assess developability and manufacturability, select leads, and support go/no-go decisions
• Support molecule advancement through process development and formulation while identifying technical risks and recommending practical experiments or external capabilities
• Write SOPs, maintain and troubleshoot instruments, document work in the ELN for intellectual property and regulatory filings, present results, and monitor platform advances

Required Skills and Qualifications

• PhD in chemistry, chemical biology, biochemistry, molecular biology, or a related field with 0–3 years of postdoctoral or industry experience; or MS with 5+ years of industry experience
• Hands-on experience synthesizing, purifying, and characterizing research-scale ASOs, siRNAs, or bioconjugates using automated solid-phase synthesis, chromatography, and mass spectrometry
• Working knowledge of ASO/siRNA therapeutic chemistry, backbone and sugar modifications, class-related toxicity, various delivery approaches
• Strong research productivity demonstrated through publications, patent filings, or comparable technical contributions
• Clear written and verbal communication skills, sound scientific judgment, and the ability to manage multiple projects in a collaborative, fast-paced team
• Ability to regularly work onsite at our HQ in New York City

Preferred Skills and Qualifications

• Industry experience in a small, fast-paced biotech is highly preferred
• Working knowledge of AAV biology and vector design
• Hands-on experience in AAV capsid engineering, pooled library design, and NGS data analysis
• Antibody- or peptide-oligonucleotide conjugate (AOC/POC) design or linker discovery

$111,400 - $150,000 a year

Compensation is dependent on qualifications and experience

About LEXEO

Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease. By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach. The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.