Scientist I/II, Analytical Development (Contract to Hire)

Senti Biosciences; South San Francisco (CA); On-site; USD 80,000 - 100,000; Full time

Job summary

A leading company in immunotherapy is seeking a highly motivated individual for the Analytical Development role focused on FACS methods. The successful candidate will contribute to the advancement of proprietary cell engineering platforms by developing and qualifying methodologies for product characterization and release. Ideal for candidates with a strong background in Cell Biology, this position offers significant growth opportunities in a collaborative work environment.

Benefits

Significant growth opportunity

Empathetic and supportive coworkers

Qualifications

• PhD with 2 years or Master’s with 4-6 years of experience in Analytical Development.
• Experience with CAR-T, CAR-NK, or immunology is a plus.
• Familiarity with cGMP workflows and regulatory filings.

Responsibilities

• Develop and qualify FACS methods for drug products.
• Collaborate with R&D and write CMC sections for Regulatory filings.
• Independently perform experiments and analyze data.

Skills

Analytical Development

FACS methods

Problem-solving

Communication

Education

Graduate degree in Cell Biology

PhD or Master's in Analytical Development

Tools

MS Office

Job description

Senti Bio seeks a highly motivated and experienced individual with a background in Analytical Development of flow-cytometry (FACS) based methods. The successful candidate will contribute to the advancement of Senti’s proprietary immunotherapeutic cell engineering platforms into the clinic. The role will drive the development of FACS-based methods for characterization and release of Senti’s drug products. Specifically, this role will support the development of new and existing methods, assess qualification readiness and transfer of methods to QC, and use FACS and other methods to support characterization of our drug products and manufacturing processes. The ideal candidate is technically strong in the development and troubleshooting of FACS-based methods, with a desire to educate others on best practices, an enthusiastic team-player, able to think outside of the box to achieve goals and interested in expanding their Analytical Development experience.

Responsibilities

• Collaborate with R&D to understand relevant product characteristics.
• Identify and develop key FACS methods for characterization and release of drug product and manufacturing processes.
• Testing support to enable product and process understanding.
• Drive the development, qualification readiness, and transfer of release methods to QC
• Collaborate with Analytical team members in the development of other assays as needed, such as immune- or cell-based functional assays.
• Support the writing of CMC sections of Regulatory filings.
• Write Test Methods and SOPs.
• Independently perform experiments, analyze data, and present results.
• Successfully design, execute, and document laboratory procedures and experiments with great attention to detail.

Qualifications

• Graduate degree in Cell Biology or related life science field. PhD with 2 years or Master’s with 4-6 years of hands-on industry experience in Analytical Development, Quality, or some combination of the above required experiences
• Industry or academic experience with CAR-T, CAR-NK, cell therapy, or immunology is a plus.
• Demonstrated experience with cGMP workflows, from development to pre-qualification, qualification, validation, and tech transfer to QC
• Significant hands-on experience with developing multi-color (5+) flow cytometry-based assays
• Experience with Regulatory filings
• Ability to multitask and meet deadlines in a fast-paced environment
• Ability to think critically and demonstrate troubleshooting and problem-solving skills with team members and third-party vendors.
• Must be a team player, proactive and willing to work in a small team environment
• Must have excellent verbal and written communication skills, including experience delivering presentations to executive stakeholders and external partners
• Proficient with MS office and other commonly used software and technology platforms
• Self-motivated and eager to take on temporary responsibilities outside of initial job description

Salary and Benefits

• Compensation for this role includes hourly base pay.
• The hourly base pay for this role is $64.00- $79.00. Starting pay is determined by multiple job-related factors including a candidate’s skills, education and experience level, benchmark, and internal parity.
• Significant growth opportunity as the company expands.
• Empathetic, supportive, and collaborative colleagues and work environments