Scientist I, Biology

Codebreaker Labs; Boulder (CO); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

Equity

Job summary

Codebreaker Labs in Boulder, CO seeks a hands-on laboratory scientist to execute genetic screening, cell engineering and phenotyping in challenging human cell models, including primary T cells and iPSC-derived systems. You will join a collaborative team of scientists and contribute to experimental planning, execution and data analysis.

You will work with computational colleagues, apply AI-enabled tools, and document methods with ELN/LIMS, building independent experimental design as you grow.

Qualifications

• Hands-on experience in mammalian cell culture, including challenging cell models like primary cells or iPSCs.
• Experience with CRISPR-based gene editing or related screening technologies.
• Familiarity with phenotypic characterization techniques such as flow cytometry, sequencing-based assays or functional immune assays.

Responsibilities

• Execute high-throughput functional genomics programs using CRISPR and related perturbation technologies in human cells.
• Culture and execute workflows for demanding human cell systems including primary cells and iPSC-derived models.
• Apply phenotyping approaches, including single-cell RNA-seq and other readouts, flow cytometry and functional assays.
• Identify opportunities to improve existing assays and contribute to their implementation.
• Contribute to experimental planning and data analysis with computation colleagues to ensure properly structured data.
• Perform careful experimental execution, troubleshooting, quality control and documentation.

Skills

CRISPR-based gene editing

Flow cytometry

Single-cell sequencing

Data analysis (R/Python)

Attention to detail

Education

MS or PhD in immunology, molecular biology, genomics, cell biology or related field

Tools

R

Python

ELN/LIMS

Job description

The opportunity

Codebreaker is building a modern functional genomics research engine to connect human genetic variation to cellular function at scale.

This is a hands-on laboratory scientist role. You will execute genetic screening, cell engineering and phenotyping workflows across challenging human cell models, including primary T cells, other primary cells, fibroblasts and iPSC/iPSC-derived systems. Working closely with Senior Scientists and the Director of Biology, you will contribute to experimental planning, execution, troubleshooting and data analysis while developing increasing independence in experimental design and interpretation.

You will partner closely with computational biology and machine learning colleagues and use modern AI tools as part of your daily scientific workflow to improve the quality, speed and scope of what the team can accomplish. You should genuinely enjoy experimental work, take ownership of problems, prioritize what matters most, move quickly, and put in the extra effort when an experiment or troubleshooting requires it.

What you will do

• Execute high-throughput functional genomics programs using CRISPR and related perturbation technologies in human cells.
• Culture and execute workflows for technically demanding human cell systems — including primary T cells, other primary cells, fibroblasts and iPSC/iPSC-derived models — according to established experimental plans.
• Apply phenotyping approaches, ideally including single-cell RNA-seq and other single-cell or multi-omic readouts, flow cytometry, and functional cellular assays.
• Identify opportunities to improve established assays and workflows, and contribute to their implementation.
• Contribute to experimental planning and data analysis, and work with computational colleagues to ensure data are accurately structured and annotated.
• Perform careful experimental execution, troubleshooting, quality control and documentation, escalating complex issues appropriately.
• Maintain detailed and reproducible documentation of experiments, protocols and results using ELN/LIMS and other appropriate systems.
• Use AI-enabled tools where appropriate to support experimental planning, execution, documentation and data analysis.
• Present experimental results and progress updates to the research team, and contribute to internal documentation and, where appropriate, publications and external presentations.
• Collaborate closely with Senior Scientists, research associates and computational colleagues to support research program objectives.

What we are looking for

• MS or PhD in immunology, molecular biology, genomics, cell biology or a related field, with relevant hands-on laboratory research experience.
• Hands-on experience in mammalian cell culture, ideally with challenging cell models (e.g. primary cells and/or iPSCs), and with CRISPR-based gene editing or related screening technologies — or strong readiness to develop this expertise quickly.
• Familiarity with phenotypic characterization techniques such as flow cytometry, sequencing-based assays or functional immune assays.
• Solid quantitative and analytical skills; comfortable working with structured datasets, standard data analysis tools (e.g. R, Python) and AI-assisted analysis tools — or motivated to build these skills.
• Strong attention to detail, record-keeping and communication skills.
• Ability to work both independently on well-defined tasks and collaboratively within a team-based research environment.
• Strong work ethic and eagerness to get things done. You show up ready to prioritize the most important task in front of you, move quickly, and are willing to put in extra time when an experiment or deadline calls for it.

Especially valuable

• Prior experience with human cell culture (e.g. primary cells or iPSCs).
• Exposure to high-throughput or pooled screening methodologies.
• Familiarity with sequencing-based genomics platforms (e.g. single-cell or bulk platforms such as 10x Genomics).
• Prior experience in a biotech or academic research lab setting, and eagerness to bring that same hands-on energy to a fast-moving startup team.

Why Codebreaker

This role offers real hands-on ownership from day one. You will help build, run and troubleshoot the cell systems, assays and workflows our science depends on — work that shapes not just your own experiments, but how the whole biology team operates as we scale.

The right person will have room to grow quickly into more independence and responsibility. If you are happiest at the bench, energized by hard problems, and excited to help build a lab from the ground up, we would like to meet you.

Compensation and benefits

Compensation: $90,000–$115,000 per year. Compensation also includes meaningful early-stage equity. Where an offer lands within the range depends on demonstrated scope, depth and prior impact.

Benefits: Competitive benefits package. Full details are shared during the interview process.