Scientist I, Bioconjugate Lead - Protein Sciences

Ampersand; Massachusetts; Hybrid; USD 100,000 - 143,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Ampersand Biomedicines seeks a highly motivated scientist with a PhD in Biochemistry or Chemical Biology to lead antibody-oligonucleotide/drug conjugate (AOC/ADC) and protein sciences programs. The role focuses on developing novel antibody modalities for tissue-targeted biotherapeutics and advancing translational platforms.

Responsibilities include leading cross-functional studies, supervising data interpretation, CRO collaboration, and deploying state-of-the-art analytical techniques to drive

Qualifications

• PhD in Biochemistry, Chemical Biology, or related field with 2+ years of experience.
• Experience with AOC/ADC platforms and protein science is preferred.
• Experience supervising studies and CRO collaboration.
• Strong analytical and data interpretation capabilities.
• Experience with chromatography and protein analytics techniques.

Responsibilities

• Collaborate with cross-functional teams to develop AOC/ADC biomolecules for targeted tissue delivery.
• Co-lead AOC/ADC projects and advance therapeutic candidates with stakeholders and CROs.
• Supervise study design and data interpretation for in vitro and in vivo work.
• Develop platform for biophysical and biochemical analyses of antibody modalities.

Skills

AOC/ADC expertise

Antibody engineering

Bioconjugation chemistry

Oligonucleotide therapeutics

siRNA design

Data interpretation and presentation

Communication skills

CRO management

Education

PhD in Biochemistry, Chemical Biology, or related field

Tools

ÄKTA chromatography

Size-exclusion chromatography (SEC)

Hydrophobic interaction chromatography (HIC)

Ion-exchange chromatography (IEX)

Mass spectrometry

Dynamic light scattering (DLS)

Mammalian cell culture (aseptic)

Plasmid transfection

Job description

Ampersand Biomedicines is a Flagship Pioneering company on a mission to transform patients’ lives with programmed medicines that work precisely where needed, and nowhere else. We’re building a collaborative, mission-driven team that thrives in a fast-paced environment and shares a genuine desire to make a difference. We ACT our values by working with Agility to adapt and deliver impact, leading with Compassion to put people first, and practicing Transparency to build trust through openness, clarity, and integrity. At Ampersand, employees are encouraged to explore breakthrough science, take chances, support one another, and contribute ideas and perspectives openly.

The Role

Ampersand is currently seeking a highly motivated scientist with a background in antibody-oligonucleotide/drug conjugate (AOC/ADC) and protein sciences to contribute to the discovery and development of AND-Body™ Therapeutics. This position will emphasize creating and analyzing new antibody modalities to develop biologic therapies targeted at specific tissues.

Key Responsibilities

• Collaborate with cross-functional teams to develop AOC/ADC biomolecules that enable targeted delivery to tissues of high interest.
• Co-lead AOC/ADC projects to advance therapeutic candidates, working closely with Ampersand stakeholders, advisors, and CRO collaborators.
• Supervise the design and execution of studies, as well as in the interpretation of data for both in vitro and in vivo research.
• Develop a state-of-the-art platform to facilitate biophysical and biochemical analyses of novel antibody modalities.

Required Professional Experience & Qualifications

• Strong technical background in AOCs; direct experience with siRNA design, antibody engineering, bioconjugation chemistry, or oligonucleotide therapeutics is highly preferred.
• PhD in Biochemistry, Chemical Biology, or a related scientific discipline with 2+ years of experience; exceptional candidates with significant experience and without a doctorate will be considered.
• Previous industry experience is advantageous but not required.
• Hands-on experience in chromatography (ÄKTA, SEC, HIC, and IEX) and protein analytics (mass spectrometry, DLS).
• Direct experience with aseptic mammalian cell culture and plasmid transfection.
• Experience managing CROs.
• Excellent written and verbal communication skills, with the ability to clearly interpret data and present results to project teams.

Preferred Professional Experience & Qualifications

• Demonstrated hands‑on expertise with site‑specific, bioorthogonal conjugation technologies (e.g., enzymatic conjugation, engineered cysteines ).
• Knowledge of linker chemistry and stability optimization strategies.
• Experience in antibody purification and/or protein engineering.
• Experience working in a biotech or translational research environment.
• Strong statistical and data analysis skills.

Ampersand Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

The salary range for this role is $100,000.00 - $143,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Ampersand currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Ampersand’s good faith estimate as of the date of publication and may be modified in the future.