Scientist I, Bioanalysis and DMPK

Eisai US; Cambridge (MA); On-site; USD 94,000 - 125,000; Full time

Job summary

An established industry player is seeking a motivated Scientist I to join their dynamic DMPK group. This role focuses on developing bioanalytical methods and conducting in vitro ADME studies to support groundbreaking research in neurology and oncology. You'll collaborate with a global team, ensuring high standards in data analysis and project management, while also contributing to regulatory filings. If you're passionate about making a difference in healthcare and thrive in a fast-paced environment, this opportunity is perfect for you. Join a company dedicated to innovation and excellence in drug development.

Benefits

Annual Incentive Plan

Employee Benefit Programs

Qualifications

• Ph.D. in relevant field with 0-2 years of experience in the pharmaceutical industry.
• Proficiency in analytical techniques for small molecule analysis is essential.

Responsibilities

• Develop and optimize bioanalytical methods for ADME studies using LC-MS/MS.
• Analyze data, generate reports, and ensure compliance with DMPK standards.

Skills

Analytical Techniques

Method Development

Troubleshooting

Communication Skills

Team Collaboration

Education

Ph.D. in Pharmacology

Ph.D. in Chemistry

Ph.D. in Pharmaceutical Sciences

Tools

LC-MS/MS

UPLC/HPLC

Excel

GraphPad

Phoenix

Job description

Scientist I, Bioanalysis and DMPK

Apply locations Massachusetts, Cambridge time type Full time posted on Posted 30+ Days Ago job requisition id R3603

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai’s human health care (hhc) mission. We’re a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer’s disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you.

Job Summary

The Drug Metabolism and Pharmacokinetics (DMPK) group at the Eisai Center for Genetics-guided Dementia Discovery in Cambridge, MA is seeking a multidisciplinary, team-oriented Scientist I with a strong emphasis on quantitative bioanalysis and general ADME/DMPK expertise. The primary responsibilities of this position will be the development of bioanalytical methods using LC-MS/MS and conducting in vitro ADME studies supporting discovery projects, in collaboration with the global DMPK team. This is a lab-focused position, especially in the initial years, with the potential to expand into a DMPK project functional lead role on cross-functional teams. Additional duties may include collaborating with internal and external academic and Contract Research Organization (CRO) partners, tracking study progress, reviewing data, uploading results into databases, and representing the Eisai DMPK team in external initiatives such as the IQ Consortium.

Essential Functions

1. Develop and optimize bioanalytical methods for in vivo study samples and in vitro ADME studies using LC-MS/MS, and independently operate and maintain instruments, with the ability to troubleshoot as needed.
2. Adhere to study protocol SOPs and conduct a variety of in vitro ADME experiments, including but not limited to stability studies using microsomes, hepatocytes, tissue homogenates, and plasma/medium fu measurement assays, in accordance with project requirements.
3. Analyze raw data and generate reports, including relevant parameters for in vitro ADME and in vivo PK assays, in compliance with Eisai’s global DMPK standards and within established timelines.
4. Communicate research findings to supervisors and project managers, process data, summarize results in report format, and upload findings into the database promptly.
5. Provide technical and scientific supervision/oversight to junior bio-analyst personnel within the team.
6. Maintain a detailed laboratory notebook and ensure all documentation is completed in accordance with standard operating procedures.
7. Participate in comprehensive mechanistic ADME studies and, as necessary, contribute to the authorship of scientific manuscripts for publication.
8. Ensure effective collaboration with internal and external partners, track study progress, review and audit data, and upload findings into the database.
9. Represent the DMPK function in multidisciplinary project teams.
10. Act as a representative for Eisai in external collaborations, including involvement with the IQ Consortium.
11. Contribute to regulatory filings, including Investigational New Drug (IND) and New Drug Application (NDA) submissions.

Requirements

1. Ph.D. in Pharmacology, Chemistry, Pharmaceutical Sciences, or a related field, with 0-2 years of pharmaceutical industry or post-doctoral experience.
2. Proficiency in analytical techniques (UPLC/HPLC and Triple Quad/TOF Mass Spectrometry) for small molecule analysis is essential. Experience with other modalities, such as antisense oligonucleotides (ASOs) and/or antibodies, is not required but a plus.
3. Demonstrated capability in method development and troubleshooting for in vitro ADME assays.
4. DMPK and in vitro ADME knowledge is required.
5. Familiarity with industry-standard data analysis software, such as Excel, GraphPad, Phoenix, or other similar packages.
6. Familiarity with electronic lab notebooks.
7. The ideal candidate should be self-motivated, able to work efficiently and reliably in a team-oriented environment.
8. Strong written and oral communication skills.

Eisai Salary Transparency Language:

The base salary range for the Scientist I, Bioanalysis and DMPK is from 94,600-124,100. Under current guidelines, this position is eligible to participate in: Eisai Inc. Annual Incentive Plan.

Final pay determinations will depend on various factors including but not limited to experience level, education, knowledge, and skills.

Employees are eligible to participate in Company employee benefit programs. For additional information on Company employee benefits programs, visit Eisai Benefits.

Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status.

Eisai Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States.