Scientist I, Analytical Development

Vaxcyte; United States; On-site; USD 129,000 - 151,000; Full time

Job summary

Vaxcyte in San Carlos, CA is seeking an energetic Scientist I, Analytical Development to execute analytical testing and contribute to method development for biologics and vaccines. You will perform routine and non-routine assays, support optimization, and document results with cross-functional teams.

The role requires hands-on lab experience, strong problem solving, and clear technical communication. You will author protocols, SOPs, and development summaries, and help maintain GLP/GMP practices

Qualifications

• PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 0-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.
• Strong hands‑on experience with multiple analytical techniques, such as liquid chromatography (H/UPLC) and/or mass spectrometry (LC‑MS), CE, SDS‑PAGE, icIEF, enzyme kinetics, colorimetric and fluorescent plate‑based assays, ELISA, Western Blot, and PCR.

Responsibilities

• Contribute to method development, optimization, and qualification/validation readiness activities.
• Design and execute experiments to evaluate critical method parameters and define appropriate system suitability and control strategies.
• Troubleshoot assay and instrument performance issues using a structured approach; interpret data to identify likely root causes, implement corrective actions, and document outcomes and recommendations.
• Support and/or execute method transfer activities, including protocol preparation, training support, execution at receiving labs, and resolution of transfer issues.
• Author and revise analytical methods, SOPs, protocols, and technical reports; ensure clear documentation of experimental rationale, results, and conclusions for internal review and stakeholder communication.
• Partner effectively with cross‑functional teams to define analytical plans, meet project timelines, and deliver high‑quality outputs.
• Communicate experimental progress and data interpretation to direct team members and project leads; flag emerging risks for senior review.
• Contribute to a compliant, safety‑focused, and scientifically rigorous lab culture, model good documentation practices and data integrity expectations.
• May assist in orienting new team members to assays and workflows under the direction of senior staff (role does not carry any formal supervisory accountability).
• Perform routine and non‑routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV‑Vis, ELISA, electrophoresis, plate‑based assays, and other biochemical/biophysical techniques).
• Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable); identify and troubleshoot common issues.
• Perform data processing and interpretation; summarize results, trends, and potential risks, and elevate complex findings for review and decision‑making.
• Maintain accurate, timely documentation in laboratory notebooks or electronic systems; contribute to clear technical communications to project and cross‑functional stakeholders.
• Assist with routine instrument maintenance scheduling and vendor coordination as directed.
• Ensure laboratory organization, cleanliness, and compliant labeling/storage practices.
• Manage inventory of reagents, standards, and consumables; initiate procurement, track critical supplies, and support forecasting to avoid stockouts.
• Follow all Environmental Health & Safety (EHS) policies and laboratory safety practices.
• Handle chemicals and biological materials safely and in compliance with regulatory requirements.
• Ensure proper waste disposal and adherence to hazardous material handling procedures.

Skills

Data analysis

Experiment design

Troubleshooting

Scientific writing

Cross-functional collaboration

Plan and prioritize work

Communication

Education

PhD in Chemistry/Biochemistry/Biology/Pharmaceutical Sciences

MS in related field

BS in related field

Tools

HPLC/UPLC

LC-MS

CE

SDS-PAGE

icIEF

ELISA

Job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical‑stage vaccine innovation company engineering high‑fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well‑defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

• RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re‑innovate the way vaccines are delivered.
• AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
• LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness‑first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
• MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary

Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team. The Scientist I, Analytical Development, is responsible for executing analytical testing and contributing to analytical method development activities for biologics/vaccine development programs. This role performs routine and non‑routine analytical assays using modern analytical techniques, supports method optimization and troubleshooting efforts, and contributes to continuous improvement initiatives with moderate supervision while partnering effectively with cross‑functional teams. The position requires demonstrated hands‑on laboratory experience, strong technical execution, and problem‑solving skills, with the ability to independently plan and execute assigned work, analyze and interpret data, and escalate and/or drive investigations as needed. This role authors and maintains clear technical documentation, including method protocols, method development summaries, and SOPs, and communicates experimental results and conclusions to internal stakeholders.

Essential Functions

Method Development & Troubleshooting

• Contribute to method development, optimization, and qualification/validation readiness activities.
• Design and execute experiments to evaluate critical method parameters and define appropriate system suitability and control strategies.
• Troubleshoot assay and instrument performance issues using a structured approach; interpret data to identify likely root causes, implement corrective actions, and document outcomes and recommendations.
• Support and/or execute method transfer activities, including protocol preparation, training support, execution at receiving labs, and resolution of transfer issues.
• Author and revise analytical methods, SOPs, protocols, and technical reports; ensure clear documentation of experimental rationale, results, and conclusions for internal review and stakeholder communication.

Team Collaboration

• Partner effectively with cross‑functional teams to define analytical plans, meet project timelines, and deliver high‑quality outputs.
• Communicate experimental progress and data interpretation to direct team members and project leads; flag emerging risks for senior review.
• Contribute to a compliant, safety‑focused, and scientifically rigorous lab culture, model good documentation practices and data integrity expectations.
• May assist in orienting new team members to assays and workflows under the direction of senior staff (role does not carry any formal supervisory accountability).

Analytical Testing & Data Generation

• Perform routine and non‑routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV‑Vis, ELISA, electrophoresis, plate‑based assays, and other biochemical/biophysical techniques).
• Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable); identify and troubleshoot common issues.
• Perform data processing and interpretation; summarize results, trends, and potential risks, and elevate complex findings for review and decision‑making.
• Maintain accurate, timely documentation in laboratory notebooks or electronic systems; contribute to clear technical communications to project and cross‑functional stakeholders.

Laboratory Operations & Instrumentation

• Support routine instrument maintenance scheduling and vendor coordination as directed.
• Ensure laboratory organization, cleanliness, and compliant material labeling/storage practices.
• Manage inventory of reagents, standards, and consumables; initiate procurement, track critical supplies, and support forecasting to avoid stockouts.

Safety & Compliance

• Follow all Environmental Health & Safety (EHS) policies and laboratory safety practices.
• Handle chemicals and biological materials safely and in compliance with regulatory requirements.
• Ensure proper waste disposal and adherence to hazardous material handling procedures.
• Support audit and inspection readiness activities where applicable.

Requirements

PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 0-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.

• Strong hands‑on experience with multiple analytical techniques, such as liquid chromatography (H/UPLC) and/or mass spectrometry (LC‑MS), CE, SDS‑PAGE, icIEF, enzyme kinetics, colorimetric and fluorescent plate‑based assays, ELISA, Western Blot, and PCR.
• Experience independently driving method development or optimization activities preferred.
• Strong knowledge of analytical chemistry/biochemistry principles with demonstrated application to assay development and control strategies.
• Proven ability to independently troubleshoot non‑routine assay and instrument issues using structured root‑cause analysis and data‑driven decision making.
• Proficient with analytical software, data processing workflows, and statistical tools.
• Strong scientific judgment and attention to detail consistently produces high‑quality, inspection‑ready documentation.
• Plan and prioritize work, coordinate with management and the lab team, and support meeting tight timelines.
• Clear and effective written and verbal communication; able to summarize complex data, present recommendations, and collaborate across functions.
• Ability to work in a laboratory environment for extended periods.
• Ability to lift up to 25 lbs.
• Use of personal protective equipment (PPE) required.
• Contribute to a positive, inclusive, and safety‑focused laboratory culture.

Reports to

Senior Scientist, Analytical Development

Location

San Carlos, CA

Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy)

Onsite (5 days per week onsite)

Compensation

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range

$129,000 – $151,000

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.