Scientist I, Analytical Development

nant; San Diego (CA); On-site; USD 110,000 - 170,000; Full time

Job summary

ImmunityBio in San Diego, CA is seeking a Scientist I, Analytical Development to join the Analytical and Process Development team. You will assist in developing, optimizing, and validating bioassays to support cell therapy projects and ensure efficient laboratory operations.

The role focuses on potency assays (cytotoxicity, proliferation, ADCC), method development and transfer, data analysis, and training of team members.

Qualifications

• Bachelor's degree with 8+ years in immunology or related field.
• Master's degree with 5+ years in immunology or related field.
• Experience with flow cytometry, ELISA, and MSD.
• Experience with cell therapy products; NK cells a plus.

Responsibilities

• Perform cell-based assays to support process development and cell therapy projects.
• Develop and qualify potency assays including cytotoxicity, cell proliferation, and ADCC.
• Maintain, calibrate, and operate cell analytical equipment and instruments.
• Develop SOPs, analytical test methods, sampling plans and batch records.
• Support cross-functional teams to advance NK cell therapy products.
• Develop or adapt analytical methods for cell therapy products and improve processes.
• Design and execute method development and qualification for lead candidates and product characterization.
• Train team members on optimized procedures.
• Design experiments to develop, qualify, and transfer cell-based potency methods.

Skills

Cell culture

Flow cytometry

ELISA

MSD

DD-PCR

RT-qPCR

Data analysis

Aseptic technique

Technical documentation

Education

Bachelor's degree in Immunology, cell biology, biochemistry or related field

Master's degree in Immunology, cell biology, biochemistry or related field

Tools

Flow cytometer platforms

MSD instrumentation

BSL-2 laboratory experience

Job description

Company Overview

ImmunityBio is a vertically integrated commercial stage biotechnology company developing next-generation therapies that bolster the natural immune system to defeat cancers and infectious diseases. The Company's range of immunotherapy and cell therapy platforms, alone and together, act to drive and sustain an immune response with the goal of creating durable and safe protection against disease. Designated an FDA Breakthrough Therapy, ANKTIVA is the first FDA-approved immunotherapy for non-muscle invasive bladder cancer CIS that activates NK cells, T cells, and memory T cells for a long-duration response. The Company is applying its science and platforms to treating cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies that we believe sharply reduce or eliminate the need for standard high-dose chemotherapy. These platforms and their associated product candidates are designed to be more effective, accessible, and easily administered than current standards of care in oncology and infectious diseases.

Why ImmunityBio?

• ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.


• Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.


• Work with a collaborative team with the ability to work across different areas of the company.


• Ability to join a growing company with professional development opportunities.

Position Summary

The Scientist I, Analytical Development, will work as part of the Analytical and Process Development team. The role will assist in developing, optimizing and validating bioassays to support cell therapy projects and will be responsible for supporting the efficient operation of the laboratory and performing scientific studies to support cell therapy projects.

Essential Functions

• Perform cell-based assays to support Process development studies for different cell therapy projects.


• Develop and qualify potency assays including cytotoxicity, cell proliferation assays and ADCC assays.


• Maintain, calibrate and operate cell analytical equipment and instruments.


• Develop standard operating procedures, analytical test methods, analytical sampling plans and batch records.


• Provide support to cross-functional team to advance development of NK cell therapy products.


• Develop or adapt analytical methods for cell therapy products and develop process improvements and efficiencies.


• Design and execute method development and qualification in support of lead candidate selection, process development, product release and stability, and product characterization.


• Train team members on optimized procedures.


• Design and execute experiments to develop, qualify, and transfer cell-based potency methods for the testing and release of pipeline products.


• Performs ad-hoc and cross-functional duties and/or projects assigned to support business needs and provide developmental opportunities.

Education & Experience

• Bachelor's degree with 8+ years' experience in Immunology, cell biology, biochemistry or biological sciences required, or


• Master's degree with 5+ years of experience in Immunology, cell biology, biochemistry or biological sciences required.


• Experience with immunoassay technologies such as flow cytometry, ELISA and MSD and molecular assays (DD-PCR, RT-qPCR) to support the characterization of NK or T cells required.


• Experience with cell therapy products including NK cells is a plus


• Experience working in an immunology laboratory (preferably working with primary cells and cell lines) preferred


• Experience with multiple flow-cytometer platforms is a plus.

Knowledge, Skills, & Abilities

• Proficient in handling and maintaining mammalian cell culture in a BSL2 Laboratory is required.


• Demonstrated knowledge of pharmaceutical manufacturing of biotechnology products, aseptic processing, analytical method development, technology transfer, method qualification/validation and process development


• Ability to follow laboratory procedures with attention to detail and successfully execute experiments at the bench.


• Knowledge in flow-cytometry.


• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.


• Self-motivated and detail-oriented


• Ability to think critically and demonstrate troubleshooting and problem-solving skills.


• Excellent interpersonal, verbal and written communication skills


• Excellent skill in Microsoft word, Excel and data analysis

Working Environment / Physical Environment

• This position works on site in Torrey Pines, CA.


• This position is in a lab environment.


• This position does bench work in a laboratory


• Frequently working on a computer for data analysis


• Occasionally lifts 11 - 20 lbs.

This position is eligible for a