Scientist I ADME/ DMPK

Resolian; Malvern (Chester County); On-site; USD 80,000 - 110,000; Full time

Job summary

Resolian in Malvern, PA seeks a Scientist I, ADME to join our Drug Metabolism and Pharmacokinetics team. You will design and execute in vitro ADME and DMPK studies, interpret data, and communicate findings to clients.

Ideal candidates hold an MS or BS with relevant CRO experience, LC-MS/MS proficiency, and strong science communication. This role offers growth opportunities within a collaborative CRO environment.

Qualifications

• M.S. with 3+ years of relevant industry experience or B.S. with 5+ years of relevant industry experience.
• Experience conducting in vitro ADME or DMPK studies in a CRO setting.
• Strong understanding of drug metabolism, pharmacokinetics, and DDI assessment.
• Excellent verbal and written communication skills; ability to manage multiple projects.

Responsibilities

• Design, execute, interpret, and communicate in vitro ADME and DMPK studies.
• Prepare high-quality study reports, scientific summaries, and client presentations.
• Investigate technical challenges and develop scientifically sound solutions.
• Collaborate with multidisciplinary teams to drive project outcomes.

Skills

In vitro ADME

DMPK knowledge

LC-MS/MS interpretation

Multi-project management

Education

M.S. in Pharmaceutical Sciences / DMPK / Biochemistry / Chemistry

B.S. in related field

Tools

MassHunter

Analyst

Phoenix WinNonlin

MetabolitePilot

Job description

Help Shape the Future of Drug Development!

At Resolian, our scientists do more than generate data—they help bring life-changing therapies closer to patients. We are seeking a passionate and innovative Scientist I, ADME to join our growing Drug Metabolism and Pharmacokinetics team. In this role, you will partner with leading pharmaceutical and biotechnology companies to solve complex scientific challenges and generate critical insights that guide drug discovery and development programs.

This is an exciting opportunity for a scientist who thrives in a fast-paced, collaborative CRO environment and enjoys combining scientific rigor with client engagement. You'll work alongside a team of experts, leverage cutting-edge technologies, and contribute directly to advancing promising therapeutics from early development through key decision points.

If you're passionate about DMPK science, enjoy tackling complex problems, and want to make a meaningful impact across a diverse portfolio of drug development programs, we'd love to hear from you.

What You'll Do

Advance Drug Development Through Innovative Science

Design, execute, interpret, and communicate a variety of in vitro ADME and DMPK studies, including:

• Metabolic stability
• Metabolite identification
• CYP inhibition and induction
• Solubility and permeability assays

Additional responsibilities include:

• Transform complex scientific data into meaningful insights and client recommendations.
• Prepare high-quality study reports, scientific summaries, and client presentations.
• Investigate technical challenges and develop scientifically sound solutions.
• Contribute to assay development, optimization, validation, and continuous improvement initiatives.
• Ensure studies are executed to the highest scientific and quality standards while meeting client timelines and expectations.
• Collaborate closely with multidisciplinary teams to drive successful project outcomes.
• Partner with Industry-Leading Clients

As a key scientific contributor, you'll have the opportunity to build relationships with innovative pharmaceutical and biotech partners and act as a trusted scientific resource.:

• Serving as a scientific point of contact for assigned client programs.
• Participating in project kickoff meetings, scientific reviews, and client update discussions.
• Providing technical expertise during proposal development and study design activities.
• Supporting business development initiatives through scientific presentations and capability discussions.
• Building strong client relationships through responsiveness, scientific excellence, and exceptional service.

Why Join Resolian?

• Work on diverse and exciting drug development programs across the pharmaceutical and biotechnology industries.
• Collaborate with experienced scientific leaders and subject matter experts.
• Gain valuable client-facing experience in a highly respected CRO environment.
• Contribute to innovative solutions that help advance therapies toward the patients who need them.
• Be part of a growing organization that values scientific excellence, collaboration, and continuous learning.

Success in This Role Looks Like

• Delivering high-quality, scientifically sound ADME data that drives critical development decisions.
• Becoming a trusted scientific partner to clients and internal stakeholders.
• Contributing to repeat business through technical expertise and outstanding customer service.
• Helping expand Resolian's ADME capabilities through innovation, collaboration, and operational excellence.

Requirements

Required

• M.S. with 3+ years of relevant industry experience; Pharmaceutical Sciences, Drug Metabolism, Biochemistry, Chemistry, or related field with 0-3 years of relevant experience; or
• B.S. with 5+ years of relevant industry experience.
• Experience conducting in vitro ADME or DMPK studies.Experience within a Contract Research Organization (CRO) environment.
• Strong understanding of drug metabolism, pharmacokinetics, and drug-drug interaction assessment.
• Experience with LC-MS/MS data interpretation.
• Excellent verbal and written communication skills.
• Demonstrated ability to manage multiple projects simultaneously.

Preferred

• Experience in metabolite identification (MetID).
• Knowledge of regulatory guidance related to DMPK studies.
• Experience supporting pharmaceutical and biotechnology clients.
• Familiarity with software such as MassHunter, Analyst, Phoenix WinNonlin, MetabolitePilot, or equivalent.
• Previous client-facing experience.
• Experience contributing to business development activities or proposal generation.