Scientist I

Orion Group; South San Francisco (CA); On-site; USD 143,270,000 - 154,732,000; Full time

Benefits offered by this job

Medical benefits

Job summary

AbbVie is seeking a Scientist I in South San Francisco to join the Cell Line Development Group. The role involves hands-on CHO cell line development and characterization for GMP applications, supporting cancer Biotherapeutics pipelines.

The candidate will execute end-to-end workflows, perform single-cell cloning, and generate cell banks, while maintaining meticulous ELN documentation in a fast-paced environment.

Qualifications

• Associate Scientist – 0 to 2 years experience
• Scientist I – 3 to 5 years of experience
• Experience with CHO cell line development
• Flow cytometry is preferred
• dd-PCR is preferred

Responsibilities

• CHO Cell Line Development & Execution: Lead the end-to-end execution of CHO cell line development workflows for pipeline and innovation projects.
• Monoclonal Cell Line Generation & Banking: Perform single-cell cloning to generate monoclonal CHO lines and manage banks.
• Genetic & Molecular Characterization: Engineer DNA constructs; perform PCR/qPCR/NGS analyses.
• Advanced Instrumentation & Automation: Operate ViCell, Octet, flow cytometers, ambr15, HPLC, imagers.
• Cross-Functional Collaboration & Communication: Present updates with purification, analytical, formulation teams to meet timelines.
• Data Integrity & Documentation: Maintain ELN records per AbbVie data standards.

Skills

CHO cell line development

Cell culture techniques

Documentation

Tools

ViCell

Octet

Flow cytometry

Ambr15

HPLC

Automated imagers

Job description

$50 - $54/hr with medical benefits available at a cost

1 year initial contract with possibility of extension

Onsite in South San Francisco

Work shift (days/times) - 8am - 4pm (flexible)

Orion Project Services is teaming up with a market-leading pharmaceutical company on an exciting contract opportunity for a Scientist I. This is a fantastic chance to apply your scientific expertise in a collaborative, fast-paced environment while supporting important research and development activities. The ideal candidate will bring strong laboratory skills, attention to detail, and a commitment to quality, safety, and accurate documentation. If you’re eager to grow your experience and contribute to meaningful work within the pharmaceutical industry, we’d love to hear from you.

Job Summary:

The Cell Line Development Group in South San Francisco, CA is seeking a Scientist I/II to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our cancer pipeline candidates.

Key Responsibilities:

• CHO Cell Line Development & Execution: Lead the end-to-end execution of CHO cell line development workflows for both pipeline and innovation projects. This includes managing post-transfection selective pressures, high-throughput screening, and scaling cultures from 96-well plates to shake flasks.
• Monoclonal Cell Line Generation & Banking: Expertly perform single-cell cloning to generate and establish monoclonal CHO cell lines. Create, expand, and meticulously characterize master and working cell banks.
• Genetic & Molecular Characterization: Engineer and generate complex DNA vector constructs for expressing antibodies and novel protein formats. Perform deep genetic characterization of cell banks by extracting DNA/RNA for analysis via PCR, qPCR/ddPCR, and Next-Generation Sequencing (NGS).
• Advanced Instrumentation & Automation: Skillfully operate and maintain a suite of key laboratory instruments, including ViCell, Octet, flow cytometers, ambr15, HPLC, and automated imagers.
• Cross-Functional Collaboration & Communication: Present scientific updates at cross-functional meetings, collaborating closely with colleagues in purification, analytical, and formulation development to drive projects forward and meet aggressive timelines.
• Data Integrity & Documentation: Maintain meticulous, contemporaneous records of all experimental designs, data, and analysis in electronic lab notebooks (ELNs), ensuring compliance with AbbVie's standards for data integrity and good documentation practices.

Qualifications:

• Associate Scientist – 0 to 2 years experience
• Scientist I – 3 to 5 years of experience
• Experience with CHO cell line development
• Flow cytometry is preferred
• dd-PCR is preferred

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