Scientist, Early Discovery & Immunology

BeOne Medicines Ltd.; San Carlos (CA); On-site; USD 137,000 - 171,000; Full time

Job summary

BeOne Medicines Ltd. in San Carlos, CA, is seeking a highly motivated Scientist to join the early discovery group. The role focuses on executing core cell engineering, assay, and screening workflows to transform novel biological concepts into scalable therapeutic assets.

You will design and execute rigorous experimental strategies to modulate the immune system and deliver milestone-moving data. You will work across diverse projects, collaborate cross-functionally, and contribute to lab

Qualifications

• Ph.D., M.S., or B.S. in Immunology, Cell Biology, Bioengineering, Molecular Biology, or a related field with 4+ years (M.S.) or 6+ years (B.S.) of experience.
• Demonstrated hands-on expertise in at least two of the following: primary T-cell biology, iPSC culture, gene editing, lentiviral cell engineering, mRNA design/delivery, functional screening.
• Working knowledge of standard molecular biology techniques (cloning, qPCR, plasmid assembly).

Responsibilities

• Design, execute, and analyze experimental workflows to generate high-quality data packages for early discovery projects.
• Perform molecular biology techniques to support construct design, library assembly, and vector/mRNA preparation.
• Isolate, culture, and engineer primary human immune cells (e.g., T cells) and manage iPSC culture/differentiation workflows.
• Execute multi-color flow cytometry (panel design) and functional assays (cytokine profiling, cytotoxicity).
• Build, optimize, and run functional screening approaches (pooled/arrayed) for target evaluation.
• Troubleshoot assays, analyze data, and guide project decisions with data-driven insights.
• Present results to cross-functional teams and leadership; contribute to Lab operations at San Carlos site.

Skills

Primary T‑cell biology

iPSC culture

Gene editing modalities

Lentiviral cell engineering

mRNA design/delivery

Functional screening

Education

Ph.D./M.S./B.S. in Immunology or related field

Tools

Flow cytometry

FACS

qPCR

Cell sorting

Job description

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description

Candidates must be able to work onsite in San Carlos, California.

At BeOne Institute, We Extend BeOne’s Execution Strength With a Dedicated Innovation Engine, Bringing Agility And Scientific Depth To Transform Uncertainty Into Actionable And High-impact Therapeutic Opportunities. We Operate According To Three Core Principles

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.
• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

At BeOne Medicines, we challenge the status quo to develop first-in-class therapies. We are seeking a highly motivated, rigorous Scientist to join our early discovery group within our agile biotech ecosystem. This role requires hands‑on laboratory execution and a drug‑development mindset. As a Scientist, you will focus on executing core cell engineering, assay, and screening workflows to move novel biological concepts into scalable therapeutic assets. You will work dynamically across diverse project initiatives, design and execute rigorous experimental strategies to modulate the immune system, and contribute cross‑functionally. We are looking for an individual who combines technical precision at the bench with a collaborative spirit and a drive to generate milestone‑moving data.

Essential Functions Of The Job

• Support early discovery projects by independently designing, executing, and analyzing experimental workflows to generate high‑quality data packages.
• Perform routine and complex molecular biology techniques to support construct design, library assembly, and vector/mRNA preparation.
• Isolate, culture, and engineer primary human immune cells (such as primary T cells) and/or manage iPSC culture and differentiation workflows.
• Execute multi‑color flow cytometry, cell sorting (FACS), magnetic isolation, and quantitative immune‑cell functional assays (e.g., cell activation, cytotoxicity, cytokine profiling).
• Build, optimize, and run functional screening approaches (pooled or arrayed) to evaluate novel targets and therapeutic constructs.
• Troubleshoot technical assays, analyze biological data, and contribute experimental insights to guide project strategy and decision‑making.
• Present clear experimental results and data packages to cross‑functional project teams and discovery leadership.
• Contribute to laboratory operational workflows, technical protocols, and material management at the San Carlos site.

Supervisory Responsibilities

• None

Requirements

Travel: No

• Ph.D., M.S., or B.S. degree in Immunology, Cell Biology, Bioengineering, Molecular Biology, or a related scientific field, and 4+ years (M.S.), or 6+ years (B.S.) of relevant industry or academic experience.
• Demonstrated hands‑on expertise in at least two of the following key technical areas:
• Primary T‑cell biology
• iPSC culture and differentiation
• Gene editing modalities (CRISPR, CRISPRa/i, base editing)
• Lentiviral or non‑viral cell engineering
• mRNA design, formulation, or delivery
• Functional screening approaches
• Working knowledge of standard molecular biology techniques (e.g., cloning, qPCR, plasmid assembly).
• Hands‑on experience with multi‑color flow cytometry including panel design and primary immune‑cell functional assays.
• Proven technical proficiency with cell sorting and isolation techniques.
• Demonstrated ability to independently design and execute experiments, rigorously analyze data, and present results clearly.

Preferred

• Prior experience working in drug discovery or translational biology environments.
• Hands‑on experience processing and analyzing in vivo tissue or blood samples.
• Experience with 3D cell culture systems (e.g., organoids, tumor spheroids, or microfluidic models) to evaluate immune cell activity.
• Basic programming skills in R or Python for biological data processing and analysis.

Global Competencies

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $136,600.00 - $170,700.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job‑related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non‑Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [e-mail].