Scientist, Discovery Sciences & Technologies

Gilead Sciences; Foster City (CA); On-site; USD 146,000 - 190,000; Full time

Job summary

A leading biotechnology company seeks a motivated Scientist for their Discovery Sciences & Technologies group. This role focuses on advancing lipid nanoparticle technology for drug delivery in various therapeutic areas, demanding strong expertise in formulation and in vivo study design. Join a high-performing team dedicated to innovation and impactful scientific research.

Benefits

Company-sponsored medical, dental, vision, and life insurance plans

Discretionary annual bonus

Paid time off

Qualifications

• 5+ years post-graduate research experience in lipid nanoparticle formulation.
• Proven track record of publications or patents in drug delivery systems.

Responsibilities

• Lead LNP technology advancement aligned with therapeutic objectives.
• Establish analytical methods for LNP characterization.
• Design and coordinate in vivo studies for LNP evaluation.

Skills

Experimental design

Troubleshooting

Data analysis

Education

Ph.D. in Pharmaceutical Sciences

Ph.D. in Biochemistry

Ph.D. in Cell Biology

Tools

Statistical software

Job description

Scientist, Discovery Sciences & Technologies

Join to apply for the Scientist, Discovery Sciences & Technologies role at Gilead Sciences

Scientist, Discovery Sciences & Technologies

Join to apply for the Scientist, Discovery Sciences & Technologies role at Gilead Sciences

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Gilead – Scientist, Discovery Sciences & Technologies

Hiring Manager: Zhengmao Ye, Senior Director, Discovery Sciences & Technologies

Location: Foster City, CA

Position Overview

We are seeking a highly motivated and creative Scientist to lead our Lipid Nanoparticle (LNP) technology advancement within the Discovery Sciences and Technologies (DST) Department. This pivotal role will enable and drive innovation in LNP-based drug delivery across Virology, Oncology, and Inflammation therapeutic areas.

DST Department members are responsible for the design and execution of rigorous, quantitative, and physiologically relevant in vitro biochemical and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate.

The successful candidate will be an integral senior member of a high performing research core team dedicated to LNP-based discovery research for therapeutic applications while also establishing strategic partnerships and driving scientific innovation. This individual will work closely with various research functions and external collaborators to advance transformational nucleic acid-based therapies into clinical development for patients.

Our company is a highly matrixed organization and the ability to work effectively across diverse functional groups and therapeutic areas is a key attribute for this role.

Specific Responsibilities

• Execute scientific strategy for LNP technology advancement aligned with therapeutic area objectives and priorities
• Design and optimize novel LNP formulations incorporating diverse nucleic acid cargos.
• Establish and validate an array of analytical methods for comprehensive LNP characterization including size distribution, charge, morphology, encapsulation efficiency, and stability profiling.
• Develop and execute cell-based high-throughput screen to evaluate and optimize delivery efficiency, safety and cellular tropism.
• Design and coordinate in vivo studies in collaboration with therapeutic areas to assess biodistribution, pharmacodynamics, efficacy, immunogenicity and toxicity of LNP formulations.
• Contribute to the preparation of scientific reports, manuscripts, and patent applications.
  
  

Minimum Qualifications

• Ph.D. in Pharmaceutical Sciences, Biochemistry, Cell biology or a related field.
• 5+ years of post-graduate research experience in lipid nanoparticle formulation and development for nucleic acid therapeutics.
• Proven track record of publications and/or patents in LNP based technologies and/or other drug delivery systems.
• Deep expertise and extensive hands-on experience in LNP formulation, characterization and bioconjugation.
• Demonstrated ability to design and execute in vitro and in vivo studies for LNP evaluation and optimization.
• Strong research background in immunological applications, particularly in evaluating mRNA-LNP efficacy.
• Experience in molecular biology and therapeutic mRNA design is a plus.
• Proficiency in data analysis tools and statistical software.
• Excellent experimental design and troubleshooting skills, with the ability to meticulously document laboratory procedures and experiments. Ability to multitask effectively in a dynamic, fast-paced research environment.
• Strong project management skills with ability to carry out multiple projects simultaneously while maintaining high quality standards.
• Excellent verbal and written communication skills with the ability to influence and collaborate effectively across disciplines and present to executive leadership.
  
  

The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For Additional Benefits Information, Visit

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
  
  

For Jobs In The United States

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [e-mail] for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT

YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees And Contractors

Please apply via the Internal Career Opportunities portal in Workday.

Seniority level

• Seniority level

  Not Applicable

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Biotechnology Research and Pharmaceutical Manufacturing

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