Scientist- CBA

thejacksonlaboratory; Bar Harbor (ME); On-site; USD 86,000 - 144,000; Full time

Job summary

The Jackson Laboratory in Bar Harbor, ME is seeking a Scientist to join the Core Scientific Services team in the Metabolic Phenotyping Core. You will lead in vivo metabolic phenotyping studies and collaborate with researchers across programs.

The role requires a Ph.D. or equivalent with 4+ years of experience in metabolic biology. You will develop SOPs, analyze data, mentor staff, and help drive innovations in phenotyping workflows.

Qualifications

• Master's degree required; Ph.D. preferred.
• 4+ years of relevant scientific experience in core facilities or CRO/academic settings.
• Experience with advanced lab technologies and data analysis.
• Track record of scientific contributions and project leadership preferred.

Responsibilities

• Design and execute in vivo metabolic phenotyping workflows.
• Analyze, interpret, and communicate experimental data to diverse audiences.
• Evaluate and validate new technologies and workflows.
• Develop and maintain SOPs, QC, and best practices for data integrity.
• Troubleshoot technical and scientific issues; propose innovative solutions.
• Collaborate with multidisciplinary teams on research initiatives and grants.
• Train and mentor staff, students, and lab personnel.
• Support strategic growth and continuous improvement of core services.
• Maintain compliance with institutional and safety requirements.

Skills

Independent scientist

Technical leadership

Collaborative mindset

Troubleshooting

Education

Master's degree in Biology or related field

Ph.D. preferred

Tools

Sable Systems Promethion

EchoMRI/DEXA/microCT

GTT/ITT/MMTT

Job description

Scientist,CBA
The Jackson Laboratory | Bar Harbor ME

About the Role

The Jackson Laboratory is seeking a highly motivated Scientist to join our Core Scientific Services team within the Metabolic Phenotyping Core. This position provides scientific expertise, technical leadership, and operational support for advanced in vivo metabolic phenotyping technologies and services that enable cutting-edge biomedical research across diverse scientific programs, including obesity, diabetes, MASH, atherosclerosis and muscle biology. The Scientist will partner with investigators, research staff, and cross-functional teams to develop, optimize, and implement scientific solutions that support internal and external research initiatives. This individual will leverage technical expertise to evaluate emerging technologies, troubleshoot complex scientific challenges, ensure quality standards, and deliver exceptional scientific service to a broad research community.

The ideal candidate is an independent scientist with strong technical proficiency, a collaborative mindset, and a passion for enabling scientific discovery through shared resources and innovative technologies.

Key Responsibilities

• Design, develop, optimize, and execute in vivo metabolic phenotyping workflows, assays, and methodologies that support core service operations and research objectives.
• Analyze, interpret, and communicate experimental data and results to diverse scientific audiences.
• Evaluate, implement, and validate new technologies, equipment, and workflows to enhance service capabilities and operational efficiency.
• Develop and maintain standard operating procedures (SOPs), quality control processes, and best practices to ensure data integrity and reproducibility.
• Troubleshoot complex technical and scientific issues and identify innovative solutions to improve performance and outcomes.
• Collaborate with multidisciplinary teams to support research initiatives, grant applications, publications, and strategic projects.
• Train, mentor, and provide technical guidance to research staff, students, and laboratory personnel.
• Contribute to the strategic growth and continuous improvement of core scientific services through process optimization and adoption of emerging technologies.
• Maintain compliance with institutional, regulatory, and safety requirements.

Knowledge, Skills, and Abilities

• Demonstrated expertise in one or more of the following areas: obesity, metabolic disease (including type-2 diabetes, MASH, atherosclerosis), aging, skeletal muscle biology, or islet (β-cell) biology.
• Expertise in preclinical pharmacology, including in vivo efficacy, execution, analysis, and interpretation.
• Proficiency with indirect calorimetry / metabolic cage systems (e.g., Sable Systems Promethion, or equivalent), Body composition analysis using EchoMRI, DEXA, and/or microCT, core metabolic phenotyping assays, including glucose tolerance tests (GTT), insulin tolerance tests (ITT), and mixed-meal tolerance tests (MMTT), treadmill-based endurance capacity testing.
• Hyperinsulinemic-euglycemic and hyperglycemic clamp techniques.
• Muscle biology experience is a strong plus.

Desirable:

• Surgical proficiency in transplantation techniques, including grafting under the kidney capsule

Minimum Qualifications

• Master's degree in biology, Biomedical Sciences, Genetics, Molecular Biology, Biotechnology, Bioinformatics, or a related scientific discipline required; Ph.D. preferred.
• Four (4) or more years of relevant scientific experience supporting research programs, scientific services, core facilities, biotechnology, pharmaceutical, academic, or contract research environments.
• Experience with advanced laboratory technologies, instrumentation, and scientific data analysis.
• Track record of scientific achievement demonstrated through research contributions, publications, presentations, technology implementation, or project leadership preferred.

Why Join Us

As part of Core Scientific Services, you will play a vital role in advancing research across multiple scientific disciplines while working with state-of-the-art technologies and a collaborative community of scientists. This position offers the opportunity to influence research outcomes, drive innovation, and help enable discoveries that improve human health.

Pay Range: $85987 - $143962 per year, dependent upon experience.

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.