Scientist- CBA

The Jackson Laboratory; Bar Harbor (ME); On-site; USD 86,000 - 144,000; Full time

Job summary

The Jackson Laboratory in Bar Harbor, ME seeks a Scientist to lead in vivo metabolic phenotyping within the Metabolic Phenotyping Core. You will design, optimize, and execute workflows, interpret complex data, and help implement new technologies to advance core service capabilities.

Ideal candidates will have strong independent research skills, a collaborative mindset, and a track record of scientific service with quality standards across diverse programs such as obesity and muscle biology.

Qualifications

• Master’s degree or higher in biology or related field; PhD preferred.
• 4+ years of relevant scientific experience in core facilities, biotech, or CRO environments.
• Experience with advanced laboratory technologies and data analysis.

Responsibilities

• Design, develop, and execute in vivo metabolic phenotyping workflows and assays.
• Analyze and communicate experimental data to diverse scientific audiences.
• Evaluate and validate new technologies and workflows to enhance capabilities.
• Develop and maintain SOPs, QC processes, and data integrity practices.
• Collaborate with multidisciplinary teams to support research, grants, and publications.

Skills

In vivo phenotyping

Data analysis

Experimental design

Troubleshooting

Collaborative skills

Education

Master’s degree in Biology/Biomedical Sciences or related

Ph.D. preferred

Tools

Indirect calorimetry systems

EchoMRI/DEXA/microCT

GTT/ITT/MMTT

Sable Promethion or equivalent

Job description

About the Role

The Jackson Laboratory is seeking a highly motivated Scientist to join our Core Scientific Services team within the Metabolic Phenotyping Core. This position provides scientific expertise, technical leadership, and operational support for advanced in vivo metabolic phenotyping technologies and services that enable cutting‑edge biomedical research across diverse scientific programs, including obesity, diabetes, MASH, atherosclerosis and muscle biology. The Scientist will partner with investigators, research staff, and cross‑functional teams to develop, optimize, and implement scientific solutions that support internal and external research initiatives. This individual will leverage technical expertise to evaluate emerging technologies, troubleshoot complex scientific challenges, ensure quality standards, and deliver exceptional scientific service to a broad research community. The ideal candidate is an independent scientist with strong technical proficiency, a collaborative mindset, and a passion for enabling scientific discovery through shared resources and innovative technologies.

Key Responsibilities

Design, develop, optimize, and execute in vivo metabolic phenotyping workflows, assays, and methodologies that support core service operations and research objectives. Analyze, interpret, and communicate experimental data and results to diverse scientific audiences. Evaluate, implement, and validate new technologies, equipment, and workflows to enhance service capabilities and operational efficiency. Develop and maintain standard operating procedures (SOPs), quality control processes, and best practices to ensure data integrity and reproducibility. Troubleshoot complex technical and scientific issues and identify innovative solutions to improve performance and outcomes. Collaborate with multidisciplinary teams to support research initiatives, grant applications, publications, and strategic projects. Train, mentor, and provide technical guidance to research staff, students, and laboratory personnel. Contribute to the strategic growth and continuous improvement of core scientific services through process optimization and adoption of emerging technologies. Maintain compliance with institutional, regulatory, and safety requirements.

Knowledge, Skills, and Abilities

Demonstrated expertise in one or more of the following areas: obesity, metabolic disease (including type‑2 diabetes, MASH, atherosclerosis), aging, skeletal muscle biology, or islet (β‑cell) biology. Expertise in preclinical pharmacology, including in vivo efficacy, execution, analysis, and interpretation. Proficiency with indirect calorimetry / metabolic cage systems (e.g., Sable Systems Promethion, or equivalent), Body composition analysis using EchoMRI, DEXA, and/or microCT, core metabolic phenotyping assays, including glucose tolerance tests (GTT), insulin tolerance tests (ITT), and mixed‑meal tolerance tests (MMTT), treadmill‑based endurance capacity testing. Hyperinsulinemic‑euglycemic and hyperglycemic clamp techniques. Muscle biology experience is a strong plus.

Desirable

Surgical proficiency in transplantation techniques, including grafting under the kidney capsule.

Minimum Qualifications

Master’s degree in biology, Biomedical Sciences, Genetics, Molecular Biology, Biotechnology, Bioinformatics, or a related scientific discipline required; Ph.D. preferred. Four (4) or more years of relevant scientific experience supporting research programs, scientific services, core facilities, biotechnology, pharmaceutical, academic, or contract research environments. Experience with advanced laboratory technologies, instrumentation, and scientific data analysis. Track record of scientific achievement demonstrated through research contributions, publications, presentations, technology implementation, or project leadership preferred.

Why Join Us

As part of Core Scientific Services, you will play a vital role in advancing research across multiple scientific disciplines while working with state‑of‑the‑art technologies and a collaborative community of scientists. This position offers the opportunity to influence research outcomes, drive innovation, and help enable discoveries that improve human health.

Pay Range

$85987 - $143962 per year, dependent upon experience.

About JAX

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute‑designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.

EEO Statement

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non‑discrimination laws.

Bar Harbor

The Jackson Laboratory's 43‑acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.

Ellsworth

The Charles E. Hewett Center in Ellsworth, Maine, is a state‑of‑the‑art facility that serves researchers worldwide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year‑round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants.

Farmington

JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17‑acre site on the campus of the University of Connecticut Health Center. The 183,500‑square‑foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state‑of‑the‑art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports.

Sacramento

The JAX Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two‑hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro‑pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year.

Augusta

JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.