Scientist, Assay Productization

10x Genomics; Pleasanton (CA); On-site; USD 90,000 - 120,000; Full time

Job summary

10x Genomics is seeking a Scientist I to join the Assay Productization team to advance development and commercial launch of Single Cell Genomics products. You will design experiments, generate data, and communicate findings to stakeholders.

This role requires hands-on NGS library prep, QC, documentation, and collaboration across biology, chemistry, microfluidics, and manufacturing. Independent work in a fast-paced environment is essential, with focus on PDP deliverables.

Qualifications

• BS in molecular biology, biochemistry, genetics, analytical chemistry, or a related field with 5+ years of relevant experience; or MS with 3+ years; or PhD with 1+ year.
• Hands-on experience with NGS library generation, data evaluation, and NGS workflows.
• Experience in a process or product development role with tech transfer to manufacturing or QC.
• Solid understanding of molecular biology and reagent or assay development.
• Proficiency with qPCR, HPLC, enzymatic assays, and equipment such as Bioanalyzers or Fragment Analyzers.
• Ability to design, execute, analyze, and interpret multi-step experiments with good planning and record keeping.
• Familiarity with manufacturing documentation systems and quality processes.
• Strong collaboration and communication skills; able to work across teams.
• Self-motivated and able to prioritize in a fast-paced environment.

Responsibilities

• Independently design and execute experiments including NGS library prep from cells or tissues.
• Draft and update manufacturing readiness documentation such as batch records.
• Refine QC methods and assays to assess reagent quality.
• Own deliverables end-to-end for low complexity projects, with guidance on complex ones.
• Troubleshoot failed experiments, identify root cause, and determine corrective action.
• Support reagent guard bands and stability studies.
• Update part specs and ECOs in PS/RIR documentation.
• Train QC and Production staff on new workflows.
• Present data clearly to stakeholders with interpretation.
• Communicate risks and collaborate cross-functionally to resolve issues.

Skills

NGS library generation

Data evaluation

Experiment design

Troubleshooting

Cross-functional collaboration

Independent work

Education

Bachelor's degree in molecular biology or related field

Master's degree in related field

PhD with 1+ year experience

Tools

Bioanalyzers

Fragment Analyzers

qPCR

HPLC

Enzymatic Assays

Job description

About the Role:

We are seeking a talented Scientist I to join the Assay Productization team to support the development and commercial launch of new Single Cell Genomic products. Assay Productization acts as the interface between R&D and Production, and is involved in all stages of product development from concept to post-launch activities. This is a cross-disciplinary position that works closely with Molecular Biology, Chemistry, Microfluidics, QC, and Manufacturing to develop and validate novel reagents across the 10x product portfolio.

At this level, you will independently apply scientific expertise to a variety of projects and challenges within the Product Development Process (PDP). You will identify problems, design experiments, own key AP deliverables, and communicate findings to internal stakeholders. Candidates should have hands‑on experience with NGS workflows and reagent or assay development, and the ability to work independently in a fast‑paced, dynamic environment.

What You Will Be Doing:

• Independently execute and design experiments, including NGS library preparation from single cells, tissues, or isolated DNA/RNA using 10x instruments and consumables.

• Draft, maintain, and update manufacturing readiness documentation, including production batch records, without assistance.

• Optimize and refine quality control (QC) methods and assays to assess reagent quality through a variety of analytical and functional tests.

• Own AP deliverables end‑to‑end for low complexity projects, and contribute to complex projects under guidance from an AP lead.

• Perform troubleshooting of failed experiments and reagent issues as they arise, identifying root cause and determining best course of action.

• Support reagent guard banding and stability studies.

• Update parts and shelf‑life documentation, including Part Specifications and Receiving Inspection Records (PS/RIR), via Engineering Change Orders (ECOs).

• Facilitate handoffs from R&D to Operations by training QC and Production staff on new workflows and methods.

• Present experimental data and results clearly to internal stakeholders, with well‑reasoned interpretation and analysis.

• Communicate identified risks appropriately and proactively, and collaborate cross‑functionally to resolve issues.

Minimum Qualifications:

• BS in molecular biology, biochemistry, genetics, analytical chemistry, or a related field with 5+ years of relevant experience; or MS with 3+ years; or PhD with 1+ year.

• Demonstrated hands‑on experience with NGS library generation, data evaluation, and next‑generation sequencing workflows.

• Prior work in a process or product development role, including technology transfer to manufacturing and/or QC groups.

• Solid understanding of molecular biology fundamentals and reagent or assay development, preferably within the Biotech or Life Sciences industry.

• Proficiency with analytical techniques including qPCR, HPLC, Enzymatic Assays, and instrumentation such as Bioanalyzers or Fragment Analyzers.

• Ability to independently design, execute, analyze, and interpret multi‑step experiments with diligent attention to planning, organization, and record keeping.

• Experience troubleshooting molecular biology‑based assays and identifying root cause of failures.

• Familiarity with manufacturing documentation systems and quality processes (e.g., batch records, ECOs, or equivalent).

• Strong collaboration and communication skills, with the ability to work effectively across scientific and operational teams.

• Self‑motivated with the ability to manage and prioritize work independently in a fast‑paced environment.

Preferred Qualifications

• Previous experience with single cell genomics, RNA-Seq, or other advanced NGS sample preparation workflows.

• Experience working with new and untested reagents, and designing and optimizing novel assays from early concept through validation.

• Familiarity with PLM/ERP systems such as Arena for document and parts management.

• Background in product lifecycle management (LCM) or new product introduction (NPI) processes.

• Experience contributing to or leading cross‑functional project efforts with defined deliverables and timelines.

10X ROLES

“Regular” US‑Based Jobs (Single Region) - 10x Role:

Below is the base pay range for this full‑time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

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