Scientist 3 - Nucleic Acid Technologies

Genentech; Washington (District of Columbia); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Discretionary annual bonus

On-site lab facilities

Job summary

Genentech in South San Francisco seeks a Scientist to advance nucleic acid technologies across mRNA and ASO/siRNA modalities. You will design experiments, optimize workflows, and incubate emerging methods.

The role requires hands-on molecular biology, NGS library prep, and data analysis, with strong collaboration. Ideal candidates hold a Master’s or PhD in Biological Sciences with 1+ year of relevant experience, excellent communication, and a track record of teamwork in a fast-paced setting.

Qualifications

• Master’s or PhD in Biological Sciences with 1+ year experience.
• Hands-on molecular biology: sequencing design, cloning, PCR.
• Experience with NGS library prep and data analysis tools.
• Strong written/spoken communication and collaboration.

Responsibilities

• Design and execute experiments across mRNA and nucleic acid modalities.
• Optimize workflows and develop capabilities to boost testing efficiency.
• Incubate emerging technologies and assess new biological questions.
• Analyze datasets and present findings to cross-functional partners.
• Collaborate in a fast-paced, high-impact research environment.

Skills

Molecular biology techniques

qRT-PCR

Mammalian cell culture

NGS library preparation

Data analysis (R, Python)

Benchling/SnapGene

Scientific communication

Education

Master’s or PhD in Biological Sciences

Tools

Benchling

SnapGene

R

Python

Job description

The Position

The Therapeutic Modalities and Technologies group in the Protein Sciences organization at Genentech is responsible for the design and generation of new therapeutic modalities that combine the engineering and analytical principles of multiple scientific disciplines. We are excited to be at the forefront of therapeutic design by generating molecules with unique mechanisms of action.

We are looking for an individual to join our Nucleic Acid Technologies team, which leverages innovative molecular and cellular technologies to advance Genentech’s therapeutic programs across mRNA, nucleic acid based medicines (ASO/siRNA), and novel modalities. Our team supports pipeline progress through implementation of established workflows, assay and process improvements, as well as the development of new experimental capabilities that increase efficiency and dataset dimensionality. Additionally, we serve as an incubator for novel modalities and emerging technologies, conducting early assessments of high-priority biological questions and modality-enhancing tools that can enable future therapeutic opportunities.

The Opportunity

• Design and execute experiments leveraging innovative molecular and cellular technologies to advance therapeutic programs across mRNA, nucleic acid-based medicines (ASO/siRNA), and novel modalities.

• Optimize experimental workflows and develop new capabilities to increase testing efficiency and dataset dimensionality.

• Serve as an incubator for emerging technologies, conducting early assessments of high-priority biological questions that enable future therapeutic opportunities.

• Perform techniques such as qRT-PCR, NGS library preparation, mammalian cell culture, transfection/electroporation, and cell-based screening.

• Analyze complex datasets using platforms and programming tools (e.g., Benchling, Snapgene, R, Python) and present findings to cross-functional partners.

• Collaborate closely with team members and project partners in a fast-paced, high-impact research environment.

Who You Are

• Hold a Master’s or PhD degree in Biological Sciences (Genetics, Cell Biology, Molecular Biology, Biochemistry, Genome Engineering, or a related field) with 1+ years of relevant industry or academic experience.

• Demonstrate hands‑on experience with molecular biology techniques (sequence design, cloning, PCR, qRT-PCR) and mammalian cell culture.

• Possess practical experience with NGS library preparation and data analysis platforms.

• Show excellent written and verbal communication skills with a strong collaborative mindset and eagerness to learn new scientific capabilities.

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

This position is not eligible for relocation benefits.

This position is located in South San Francisco and is an on-site laboratory research position.

The expected salary range for this position based on the primary location of California is $103,400.00 - 192,000.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.