Scientist 3 - Nucleic Acid Technologies

Roche; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Discretionary annual bonus

Comprehensive Roche benefits

Job summary

Genentech in South San Francisco, CA, is seeking a scientist to join the Nucleic Acid Technologies team within Therapeutic Modalities and Technologies. You will design and execute experiments advancing mRNA and nucleic acid based modalities, optimize workflows, and contribute to emerging technologies.

You'll perform qRT-PCR, NGS library prep, mammalian cell culture, transfection and cell-based screening, analyze data with Benchling, SnapGene, R and Python, and communicate findings to

Qualifications

• Master's or PhD in Biological Sciences with 1+ year of relevant experience.
• Hands-on molecular biology techniques including sequence design, cloning, PCR and qRT-PCR.
• Experience with mammalian cell culture and data analysis.
• Ability to communicate findings clearly and collaborate across teams.

Responsibilities

• Design and execute experiments to advance mRNA and nucleic acid modalities.
• Optimize workflows and develop new capabilities to increase testing efficiency.
• Analyze complex datasets and present findings to cross-functional partners.
• Collaborate with team members in a fast-paced research environment.

Skills

qRT-PCR

NGS library prep

Mammalian cell culture

PCR design

Cloning

Benchling

R

Python

Education

Master's or PhD in Biological Sciences

Tools

Benchling

SnapGene

Job description

Sep 3, 2026

$103,400 - $192,000/year

The Therapeutic Modalities and Technologies group in the Protein Sciences organization at Genentech is responsible for the design and generation of new therapeutic modalities that combine the engineering and analytical principles of multiple scientific disciplines. We are excited to be at the forefront of therapeutic design by generating molecules with unique mechanisms of action.

We are looking for an individual to join our Nucleic Acid Technologies team, which leverages innovative molecular and cellular technologies to advance Genentech's therapeutic programs across mRNA, nucleic acid based medicines (ASO/siRNA), and novel modalities. Our team supports pipeline progress through implementation of established workflows, assay and process improvements, as well as the development of new experimental capabilities that increase efficiency and dataset dimensionality. Additionally, we serve as an incubator for novel modalities and emerging technologies, conducting early assessments of high-priority biological questions and modality-enhancing tools that can enable future therapeutic opportunities.

The Opportunity

Design and execute experiments leveraging innovative molecular and cellular technologies to advance therapeutic programs across mRNA, nucleic acid-based medicines (ASO/siRNA), and novel modalities.

Optimize experimental workflows and develop new capabilities to increase testing efficiency and dataset dimensionality.

Serve as an incubator for emerging technologies, conducting early assessments of high-priority biological questions that enable future therapeutic opportunities.

Perform techniques such as qRT-PCR, NGS library preparation, mammalian cell culture, transfection/electroporation, and cell-based screening.

Analyze complex datasets using platforms and programming tools (e.g., Benchling, Snapgene, R, Python) and present findings to cross-functional partners.

Collaborate closely with team members and project partners in a fast-paced, high-impact research environment.

Who You Are

Hold a Master's or PhD degree in Biological Sciences (Genetics, Cell Biology, Molecular Biology, Biochemistry, Genome Engineering, or a related field) with 1+ years of relevant industry or academic experience.

Demonstrate hands-on experience with molecular biology techniques (sequence design, cloning, PCR, qRT-PCR) and mammalian cell culture.

Possess practical experience with NGS library preparation and data analysis platforms.

Show excellent written and verbal communication skills with a strong collaborative mindset and eagerness to learn new scientific capabilities.

Together, we'll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

This position is not eligible for relocation benefits.

This position is located in South San Francisco and is an on-site laboratory research position.

The expected salary range for this position based on the primary location of California is $103,400.00 - 192,000.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .

Roche is a global leader in pharmaceuticals and diagnostics, dedicated to advancing personalized healthcare and improving patient outcomes through innovative treatments and sustainable practices.

Biotechnology Research Research Services Professional Services

Company size 10,001+ employees

Company type Public company

Total funding $7.7B Post IPO Equity

Team growth

Momentum

6% in 12 mo

105,192 employees on LinkedIn

Mar 22 May 26

Employee experience

What's like inside

4.0

10,836 reviews

84% would recommend

Culture & values

4.2

Work-life balance

4.1

Career opportunities

3.6

Compensation & benefits

4.1

Capital

Funding history

Post IPO Equity - SoftBank$5B

Aug 2021

Post IPO Equity - SCALE AI$500K

May 2020

Post IPO Equity

Jan 2010

Post IPO Equity - Novartis$2.7B

May 2001

Where they work

Headquarters Switzerland