Scientist 2 - Research and Development

Mindlance; Malvern (Chester County); On-site; USD 65,000 - 90,000; Full time

Job summary

A leading company in Advanced Therapies is seeking a Scientist 2 to support CAR-T cell therapies. The role involves method development and validation for various assays such as ELISA and AlphaLISA. Ideal candidates have a relevant Master's or Bachelor's degree along with practical lab experience. Join a dynamic team committed to groundbreaking work in immuno-oncology and cell therapy.

Qualifications

• 1-2+ years of experience for Master's or 3-4+ years for Bachelor's.
• Prior experience with immortalized cell culture.
• Strong analytical and problem-solving skills.

Responsibilities

• Plan and execute ELISA, AlphaLISA, and other assays.
• Maintain cultures of immortalized cell lines.
• Document data in a good electronic lab notebook.

Skills

Analytical Problem Solving

Planning and Organizational Skills

Education

Master's Degree in Cell Biology, Immunology, or Related Field

Bachelor's Degree in Appropriate Scientific Discipline

Tools

ELISA

AlphaLISA

Plate-based Methods

Kinexa

Biacore

MSD

Job description

Scientist 2, Analytical Development, Advanced Therapies, Functional Potency Method Development The Advanced Therapies, Functional Potency Method Development group is seeking an energetic, highly motivated scientist to support CAR-T cell therapies. The contactor will serve as a specialist in binding assay method development and assay validation. Primary responsibilities: • Plan and execute ELISA, AlphaLISA, luciferase reporter, and other plate-based assays • Test samples across all CAR-T cell therapy programs • Maintain healthy cultures of immortalized cell lines according to requirements • Help keep a large inventory of reagent stocks maintained and well organized • Maintain good electronic lab notebook (ELN) practices to ensure proper data documentation • Demonstrate excellent communication and interpersonal skills • The candidate is expected to work effectively in a team environment and well as contributing individually to meet project objectives and timelines. • Other duties to be assigned as necessary. Required: • Master’s degree with at least 1-2+ years of experience or bachelor's degree with at least 3-4+ years’ experience in an appropriate scientific discipline (cell biology, immunology, biological science, or related field). • Prior experience with immortalized cell culture (adherent and suspension cells) • Prior experience with cell counting • Prior experience running plate-based methods (e.g. ELISA, AlphaLISA, MSD, and luciferase reporter assays) • Strong analytical problem solving, planning and organizational skills Preferred: • Hands-on experience with CAR-T or other cell and gene therapy products • Experience with co-culture functional assays in immuno oncology • Experience in analytical method development • Experience in analytical method qualification and validation • Experience with Kinexa and Biacore • Experience with MSD • Knowledge of ICH (Q2)R2 standards Top Three Skills: Bachelor of Science, ELISA/AlphaLISA Experience, Cell Culture Experience

Top Three Skills: Bachelor of Science, Plate-based method (ELISA/AlphaLISA) Experience, Cell Culture Experience

EEO:

“Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.”