Scientist

Collabera; Thousand Oaks (CA); On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) retirement plan

Life insurance

Paid time off

Paid holidays

Job summary

Collabera is seeking a Scientist to develop robust automation workflows for cryogenic electron microscopy (cryoEM) data processing, reporting, and scientific decision support.

This scientist will combine practical understanding of structural biology and cryoEM workflows with strong computational skills to leverage AI to reduce manual documentation, improve data traceability, and create standardized, reusable analysis tools.

Qualifications

• Deep training in cryoEM data processing (single particle analysis, tomography or MicroED).
• Familiarity with EPU and CryoSPARC software packages.
• Familiarity with Linux command line to control data processing programs without GUIs.
• Experience developing scripts, data-processing pipelines, reports, or scientific visualizations.
• Strong documentation and reproducible-development practices.
• Solid record of scientific publications, presentations or technology innovation.

Responsibilities

• Develop robust, user-centered automation workflows for cryoEM data processing and reporting.
• Leverage AI to reduce manual documentation and improve data traceability.
• Create standardized, reusable analysis tools and workflows for structural biology data.

Skills

Cryo-EM data processing

Single particle analysis

Linux command line

Scripting/programming

HPC workflows

Documentation and reproducible Dev

Education

PhD in structural biology or related field

Master's degree + relevant experience

Tools

EPU

CryoSPARC

Relion

Pymol

ChimeraX

XDS

Refmac

Coot

Job description

Standard schedule is approximately 8:00 AM-5:00 PM, Monday-Friday, with a generally consistent schedule expected. No routine overtime or weekend work is anticipated. The assignment is expected to run for 12 months,

Candidates outside the area may be considered if they are willing and able to relocate at their own expense.

The ideal candidate is an early-career structural biologist with strong, hands-on cryo-EM data-processing experience and enough scientific computing/programming proficiency to develop practical tools that improve and automate scientific data workflows. The manager is prioritizing scientific and structural-biology depth over traditional software-development expertise; candidates should understand cryo-EM data and be comfortable working beyond basic GUI/tutorial-driven workflows, including command-line environments and high-performance computing (HPC). Python is preferred, but other programming languages are acceptable. A recent PhD is ideal, although candidates with a master’s degree plus relevant experience will also be considered.

Please address these points in the candidate summary submitted with each resume:

(1) Describe the candidate’s cryo-EM experience, including the applicable subfield(s) and the work they personally performed.

(2) Confirm whether the candidate has direct, hands-on responsibility for cryo-EM data processing and structure determination/solving; please distinguish this from upstream contributions such as protein purification or sample preparation.

(3) Briefly describe the candidate’s experience with scientific computing, including command-line environments, HPC clusters/job schedulers, programming or scripting, and any examples of customizing or troubleshooting data-processing workflows.

We are seeking a Scientist to develop robust, user-centered automation workflows for cryogenic electron microscopy (cryoEM) data processing, reporting, and scientific decision support. This scientist will combine practical understanding of structural biology and cryoEM workflows with strong computational skills to leverage AI to reduce manual documentation, improve data traceability, and create standardized, reusable analysis tools.

Required qualifications:

• Deep training in cryoEM data processing (single particle analysis, tomography or microED)
• Familiarity with EPU and CryoSPARC software packages
• Familiarity with working at the Linux command line to control data processing programs without GUIs
• Experience developing scripts, data-processing pipelines, reports, or scientific visualizations
• Strong documentation and reproducible-development practices
• Solid record of scientific publications, presentations or technology innovation
• Highly organized, with great attention to detail, strong communication and excellent interpersonal skills
• Ability to work collaboratively with experimental and computational scientists

Preferred qualifications:

• Experience in at least one programming language is preferred but not strictly required
• Experience with version control (Git)
• Ability to translate scientific user needs into practical software requirements
• Experience with x-ray crystallography data processing
• Experience with Relion, Pymol, ChimeraX, XDS, Refmac, Coot, or similar software packages

Top 3 Skills:

• Deep expertise in cryoEM data processing (single particle analysis, tomography or Microcrystal electron diffraction (MicroED)) for structural biology applications
• Experience developing custom data analysis pipelines utilizing scripting and multiple programs for cryoEM data analysis
• Familiarity with working in high-performance computing clusters and at the Linux command line

The Company offers the following benefits for this position, subject to applicable eligibility requirements: medical insurance, dental insurance, vision insurance, 401(k) retirement plan, life insurance, long-term disability insurance, short-term disability insurance, paid parking/public transportation, (paid time, paid sick and safe time, hours of paid vacation time, weeks of paid parental leave, paid holidays annually - AS Applicable).