Scientist

Advanced Recruiting Partners; Boston (MA); On-site; USD 95,000 - 130,000; Full time

Job summary

A prominent staffing firm is looking for an Associate with expertise in protein purification and mass spectrometry. The ideal candidate will hold a PhD or BS/MS with extensive experience and is passionate about supporting drug discovery. Responsibilities include purifying and validating proteins, and developing strategies for protein analysis. This is a full-time science role located in Boston, Massachusetts.

Qualifications

• PhD with 2–4 years or BS/MS with 6–12 years of relevant experience.
• Experience in industry with biophysical techniques.
• Familiar with the drug discovery pipeline.

Responsibilities

• Purify high-quality recombinant proteins.
• Validate proteins with HPLC and mass spectrometry.
• Develop protein purification strategies.
• Develop and optimize purification strategies and biophysical methods to support drug discovery.
• Share results in team meetings and advise on best practices for producing protein reagents for biophysical characterization, structural biology, assay development, screening, hit identification, and immunization.

Skills

Hands-on experience with mass spectrometry instruments

Expertise using AKTA purification systems

Attention to detail

Ability to manage multiple priorities

Passion for continuous learning

Education

PhD in biochemistry, chemistry, molecular & cellular biology, or related field

BS/MS with relevant experience

Tools

Waters BioAccord mass spectrometer

AKTA purification systems

Waters BioAccord

Job description

Responsibilities

• Purify high-quality recombinant cytosolic, secreted, membrane, and refolded proteins.
• Validate proteins through quality control experiments such as HPLC, mass spectrometry, binding, and enzymatic assays.
• Perform biophysical analysis of proteins and/or protein complexes using mass spectrometry and other analytical techniques.
• Develop and optimize protein purification strategies and biophysical methods to support drug discovery programs.
• Share experimental results in team meetings and advise on best practices for generating protein reagents used in biophysical characterization, structural biology, assay development, screening, hit identification, and immunization.

Required Qualifications

• PhD in biochemistry, chemistry, molecular & cellular biology, biophysics, or a related field with 2–4 years of experience; or BS/MS with 6–12 years of relevant experience, including at least 4 years in industry.
• Hands-on experience with mass spectrometry instruments and their maintenance, along with other biophysical techniques.
• Strong expertise using AKTA purification systems and a solid understanding of modern protein purification techniques.
• Excellent attention to detail, ability to manage multiple priorities, and a passion for continuous learning.

Preferred Qualifications

• Proficiency with the Waters BioAccord mass spectrometer
• Experience with biophysical techniques such as mass photometry, thermal shift assays, fluorescence spectroscopy, etc.
• Understanding of upstream and downstream processes including molecular biology, cell culture, protein expression, structural biology, and assay development.
• Familiarity with the drug discovery pipeline and how protein reagents contribute to various stages.
• Ability to recognize critical path activities and prioritize resources to support project advancement.

Seniority level

• Associate

Employment type

• Full-time

Job function

• Science

Industries

• Staffing and Recruiting