Advisor/Senior Advisor - Oligonucleotide Chemistry

BioSpace; Indianapolis (IN); On-site; USD 126,000 - 205,000; Full time

Benefits offered by this job

Company bonus

Comprehensive benefits package

Job summary

Lilly Genetic Medicines is seeking a collaborative, creative, and energetic lead for the oligosynthesis scale-up team. The role accelerates Lilly RNAi Therapeutics from pre-clinical to clinical development and requires expertise in large‑scale oligonucleotide synthesis and modern organic/nucleic acid chemistry.

The successful candidate will oversee a multi-disciplinary team, drive method development, and communicate outcomes across CMC and Development teams to deliver essential materials for key

Qualifications

• PhD or MS with extensive oligonucleotide synthesis experience (solid-phase)
• Experience supervising a scientific team to evaluate and optimize synthetic routes
• Proficiency with chromatographic purification and analytical instrumentation

Responsibilities

• Lead oligosynthesis scale-up team to accelerate RNAi Therapeutics development
• Coach, mentor and lead a multidisciplinary team
• Collaborate with RNAi discovery chemistry teams to scale from 150 µmol to 6 mmol scales
• Support lead drug candidate discovery and provide materials for key studies
• Develop and improve synthetic methods; address oligonucleotide challenges
• Prioritize work and meet tight deadlines with the team

Skills

oligonucleotide synthesis

solid phase synthesis

team leadership

mentorship

cross-functional collaboration

communication skills

experimental design

drug discovery

Education

PhD in a relevant scientific discipline

MS in a relevant scientific discipline

Tools

AKTA LC-MS

Agilent LC-MS

UPLC

chromatographic purification

SPE

process TFF systems

solid-phase synthesis instruments

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 49,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Lilly Genetic Medicines is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous "biotech-like" company within the walls of Lilly.

The Lilly Genetic Medicines (LGM) Team is looking for a collaborative, creative, and energetic problem solver to join a multidisciplinary team at the front edge of innovation. They will join our fast-paced, interdisciplinary team as we utilize novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will utilize their knowledge and technical expertise to accelerate the core capabilities of large-scale oligonucleotide synthesis of internal RNAi-based clinical candidates. Are you skilled in large-scale oligonucleotide synthesis and interested in learning about RNAi discovery and development for impactful patient therapies? We want you on our team!

Responsibilities

• Lead the Lilly Genetic Medicines discovery oligosynthesis scale-up team to accelerate Lilly RNAi Therapeutics from pre-clinical to clinical development
• Utilize comprehensive expertise in oligonucleotide synthesis methodologies to support Lilly Genetic Medicines and further develop internal capabilities and team growth through effective coaching, mentorship, and leadership.
• Collaborate with members of the RNAi discovery chemistry teams to validate and execute requirements for oligonucleotide synthesis from 150umol to 6mmol scales including communication of relevant information and results to project leads and/or cross functional organizations within Lilly to ensure seamless operation of the scale-up team.
• Actively support our efforts toward the discovery of lead drug candidates and lead at the interface with our CMC and Development teams to provide essential materials for key studies and effectively communicate technical insights to the development team.
• Demonstrate expertise in modern synthetic organic and nucleic acid chemistry, striving to improve methods, develop new technologies, and address synthetic oligonucleotide challenges across a diverse portfolio
• Oversee and prioritize the work of scale-up team members to meet critical timelines.
• Value diverse perspectives and experiences for effective solutions. Motivate team members to take initiative, own outcomes, and share expertise on complex technical challenges.
• Guide teams through unclear situations, adapt efficiently to changes, and evaluate and implement effective approaches to completing tasks.

Basic Qualifications

• PhD degree in a relevant scientific discipline with 2+ years of experience (oligonucleotide synthesis experience, solid phase synthesis) or MS degree with 5+ years of experience (oligonucleotide synthesis experience, solid phase synthesis)

Preferred Qualifications

• Experience in supervising a team of scientists to evaluate, refine and execute synthetic routes, technologies, and practices to deliver LGM portfolio
• Experience in troubleshooting and optimizing synthetic protocols on automated solid-phase synthesis instruments
• Experience with downstream processing of oligonucleotides including use of chromatographic purification and process TFF systems
• Ability to function within a highly interdisciplinary environment
• Excellent written and oral communication skills, good organizational skills, the ability to multitask, and lead a team to deliver on tight deadlines
• Confident, execution-focused, and team oriented with a desire to thrive in a fast-paced growing environment is a plus.
• Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water's QDA, etc
• Experience in developing new chromatographic methods (IEX/RP-HPLC, SPE, LC-MS).
• Experience in conjugation of novel ligands, including small molecules, peptides, and proteins to oligonucleotides at 5-25g scale

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $126,000 - $204,600.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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