Scale-Up Process Chemist | From Lab to Manufacturing

Pulsejobs; Madison (WI); On-site; USD 120,000 - 180,000; Full time

Job summary

Pulsejobs in Madison, WI is seeking a Process Chemist to provide technical expertise in process chemistry, independently scout new reaction pathways, and scale synthetic routes from kilo to multi-kilo scale reactors up to 2000 L.

You will develop robust processes for safe operation, transfer to manufacturing, train operators, and apply NMR and UPLC-MS analyses to support regulatory filings of active ingredients.

Qualifications

• Ph.D. in Chemistry with 5 years' experience as process chemist or M.S. in chemistry with 20 years' hands-on chemistry process scale up experience.
• Strong background in scientific procedure: Data analysis, experimental design, project management, and technical writing proficiencies are required.
• Basic understanding of and willingness to learn statistical concepts. Previous statistical experience using JMP, or similar statistical software would be an advantage.
• Expertise with chemical reaction searching database, SciFinder
• Experience with large scale reactors (200L to 2000L), process equipment
• Expertise in LCMS, NMR, and other chemical structural analytical methods
• Demonstrated success working in manufacturing / technical production environments

Responsibilities

• Provide technical expertise in area of Process Chemistry
• Independently scout new chemical reaction pathways that might be useful for future inclusion on larger scale
• Scale synthetic routes validated on kilo scale into multi-kilo scale reactors (400L, 800L, 2000L)
• Develop robust chemical processes that can be transferred to technical manufacturing / chemical operators
• Identify and implement necessary process equipment to ensure safe, efficient operation of technical manufacturing
• Train Chemical Operators and Production Chemist to safely perform scaled routes
• Routinely analyze and interpret 1-dimension and 2-dimension proton nuclear magnetic resonance spectra (1D1H-NMR, 2D1H-NMR) to assign molecular structures
• Routinely perform and analyze Ultra High-Pressure Chromatography Mass Spectrometry (UPLC-MS)
• Assist in the preparation of data for regulatory filings on chemical syntheses of active ingredients

Skills

Data analysis

Experimental design

Project management

Technical writing

Statistical concepts

Education

Ph.D. in Chemistry

M.S. in Chemistry

Tools

JMP

SciFinder

LCMS

NMR

Job description

Pulsejobs in Madison, WI is seeking a Process Chemist to provide technical expertise in process chemistry, independently scout new reaction pathways, and scale synthetic routes from kilo to multi-kilo scale reactors up to 2000 L.

You will develop robust processes for safe operation, transfer to manufacturing, train operators, and apply NMR and UPLC-MS analyses to support regulatory filings of active ingredients.