RWE Director, Inhaled Portfolio

AstraZeneca GmbH; Wilmington (DE); On-site; USD 170,000 - 250,000; Full time

Job summary

AstraZeneca in Wilmington, Delaware seeks a senior leader to shape US payer-ready evidence for Airsupra and Breztri. You will design real-world evidence programs, lead observational studies, and translate findings into value narratives for payers, health systems, and policy makers.

With 5+ years in RWE and advanced training in epidemiology, health economics, or biostatistics, you will collaborate across Medical, Market Access, and Brand teams to drive access and outcomes in the US.

Qualifications

• 5+ years of RWE experience in pharma, managed care, academia, or consulting.
• Deep proficiency in observational study design and real-world data sources.
• Strong understanding of causal inference methods and bias mitigation.
• Comprehensive knowledge of the US healthcare system and payer landscape.
• Proven ability to translate evidence for non-technical stakeholders.

Responsibilities

• Lead US value proposition and brand-alignment for Airsupra and Breztri.
• Design and deliver integrated evidence plans and payer dossiers.
• Conduct observational studies, target trials, registries, and pragmatic research.
• Identify and secure fit-for-purpose real-world data sources with bias controls.
• Develop cost-effectiveness and budget impact models for HTA submissions.
• Translate RWE outputs into actionable tools for MSLs and payers.
• Collaborate with global teams to align methods and assets.
• Engage with external investigators and data providers to expand datasets.

Skills

RWE experience

Observational study design

Causal inference methods

US healthcare knowledge

Cross-functional collaboration

Education

PhD or equivalent

Master’s in Epidemiology/Health Economics

Job description

Are you ready to turn real-world data into practice-changing evidence that improves outcomes for people living with asthma and COPD? In this US-focused leadership role based in Wilmington, DE, you will shape the clinical and economic value story for our inhaled respiratory portfolio, including Airsupra and Breztri, and translate it into the language of payers, health systems, and policy makers.

Working at the center of a highly collaborative network across Medical, Market Access, Field Medical, Commercial Insights, and Brand, you will design and deliver evidence programs that close in-market gaps, inform strategy, and enable appropriate access and uptake. How would you build a payer-ready evidence plan that anticipates emerging policy shifts? Where would you focus first to remove barriers to appropriate use in routine care?

Accountabilities:

• US Value Proposition and Brand Alignment: Partner with US Medical, Market Access, Commercial Insights, and Brand teams to define and strengthen the clinical and economic value proposition for Airsupra and Breztri; align evidence priorities to brand strategy and high-stakes US decision points to drive appropriate use and access.

• Integrated Evidence Leadership: Lead facilitation of the Scientific Narrative and development of the Integrated Evidence Plan; operationalize core messages across publications, congress presentations, payer dossiers, and field resources to shape decision-maker perceptions.

• RWE Program Design and Delivery: Design, execute, and report observational studies, target trial emulations, registries, and pragmatic effectiveness research; apply causal inference and robust bias mitigation to generate credible insights that influence medical and access strategies.

• Real-World Data Strategy: Identify, evaluate, and secure fit-for-purpose claims, EMR, registry, and linked datasets; champion representativeness and health equity in study design so findings reflect US clinical practice.

• Economic and Payer Evidence: Build and contribute to cost-effectiveness and budget impact models; author AMCP Dossier sections and provide evidence inputs for PVP decks, formulary submissions, and contracting strategy to enable payer-ready value stories.

• Field Medical Enablement: Translate RWE outputs into clear, actionable insights and tools for MSLs and Clinical Account Directors engaging health systems, IDNs, payers, and population health leaders.

• Evidence-to-Practice Translation: Co-own the evidence-to-practice handoff with Implementation Science counterparts to ensure RWE leads to interventions that change care and outcomes.

• External Partnerships: Cultivate collaborations with academic investigators, learning health systems, real-world data providers, patient advocacy groups, and relevant registries or quality-measure bodies to co-design studies and expand data access.

• Global Alignment: Coordinate with global evidence and health economics counterparts to align methods and assets, and ensure US outputs inform HTA submissions, economic models, and global value dossiers.

• Responsible AI Use: Apply AI/ML tools in literature review, automated data quality checks, and signal detection with human-in-the-loop oversight; document methods and lead peer learning to strengthen team capability.

• Research Governance and Compliance: Adhere to research governance processes, including protocol review and scientific committee approvals; ensure compliance with HIPAA, GCP, and internal SOPs, and contribute to internal methods development and peer review.

Essential Skills/Experience:

• Education. Advanced degree (PhD, PharmD, MD, or relevant Master’s) in Epidemiology, Health Services Research, Health Economics, Outcomes Research, Biostatistics, or a related field.

• Experience. 5+ years of relevant RWE experience in the pharmaceutical industry, managed care, academia, or consulting.

• Methodological Expertise. Deep proficiency in observational study design, real-world data sources, and causal inference methods.

• US Healthcare Knowledge. Comprehensive, current understanding of the US healthcare system, including the evolving payer and policy landscape, quality measures, value-based care models, reimbursement dynamics, and guideline development.

• Communication. Strong written and verbal communication; demonstrated publication record and ability to translate evidence for non-technical US stakeholders.

• Cross-Functional Collaboration. Ability to work effectively across matrix teams (US and Global) with a high degree of autonomy.

Desirable Skills/Experience:

• Economic & Access Evidence. Demonstrated experience contributing to economic models, AMCP Dossiers, PVP decks, or contracting strategy inputs.

• External Engagement. Track record of building productive external partnerships with academic collaborators, registries, learning health systems, or data providers.

• AI Literacy. Familiarity with applying AI/ML tools to RWE workflows; able to evaluate validity, limitations, and bias.

• Therapeutic Area. Respiratory experience is strongly preferred, particularly in COPD or asthma and with inhaled/respiratory therapeutics.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:

Here, science and strategy meet to deliver real impact for patients. You will work with diverse experts to build ecosystem solutions that reach beyond our walls, from payer-ready evidence and quality measures to practice interventions that change care. We move with urgency and clarity, value kindness alongside ambition, and bring unexpected teams together to accelerate ideas from pilot to scale. Your evidence will inform decisions across health systems and payers while shaping the next wave of respiratory innovation.

Date Posted

11-Sept-2026

Closing Date

24-Sept-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.