Researcher 3-Neurology

Ohio State University; Columbus (OH); On-site; USD 85,000 - 110,000; Full time

Job summary

The Ohio State University is seeking a Researcher 3 in Neurology to lead large-scale projects addressing neuro-immune interactions in cancer. The role requires designing and executing studies, analyzing multidimensional data, and mentoring others within a collaborative team.

Applicants should have a PhD in a relevant field and substantial experience with mammalian systems, flow cytometry, and molecular techniques.

Qualifications

• PhD in a related field or equivalent research experience as described.
• Independently plan and conduct complex cellular, molecular or translational research.
• Experience with mouse models and animal research procedures.
• Strong record of scientific communication through reports and manuscripts.

Responsibilities

• Design, execute, optimize, and troubleshoot in vitro and in vivo studies addressing neuro-immune regulation of tumor immunity.
• Integrate data from cellular, molecular, imaging, genomic, and animal-model platforms.
• Contribute to manuscripts, grants, and presentations; mentor students and staff.

Skills

Mammalian cell culture

Flow cytometry

PCR/qPCR

Immunofluorescence / immunohistochem

Education

PhD in Biochemistry, Immunology, Cell Biology, Molecular Biology, Cancer Biology, Neuroscience, Biomedical Sciences or related

Master's + 3 years or Bachelor + 5 years research experience

Tools

CRISPR-Cas9

RNA sequencing

Confocal microscopy

Job description

Researcher 3-Neurology# Careers## Researcher 3-NeurologyApply: College of Medicine/Office of Health Sciences: Full time: Posted Today: R160512Screen reader users may encounter difficulty with this site. For assistance with applying, please contact [e-mail]. If you have questions while submitting an application, please review these frequently asked questions.**Current Employees and Students:**If you are currently employed or enrolled as a student at The Ohio State University, please log in to Workday to use the internal application process.Welcome to The Ohio State University's career site. We invite you to apply to positions of interest. In order to ensure your application is complete, you must complete the following:* Ensure you have all necessary documents available when starting the application process. You can review the additional job description section on postings for documents that may be required.* Prior to submitting your application, please review and update (if necessary) the information in your candidate profile as it will transfer to your application.## Job Title:Researcher 3-Neurology## Department:Medicine | NeurologyA Researcher 3 position is available in the laboratory of Dr. Nandini Acharya in The Ohio State University Comprehensive Cancer Center (OSUCCC) Pelotonia Institute for Immuno-Oncology (PIIO). The laboratory studies how cellular and molecular determinants within the neuro-immune axis influence cancer initiation, progression, metastasis, and therapeutic response. The research program examines how interactions among sensory neurons, macrophages, and T cells shape the tumor microenvironment and anti-tumor immunity, with the goal of identifying biomarkers and therapeutic targets for glioblastoma and other cancers. The Researcher 3 will function as a fully experienced research professional and independently conduct complex, large-scope projects with general guidance from Dr. Acharya on new initiatives. The position will design, execute, optimize, and troubleshoot in vitro and in vivo studies addressing neuro-immune regulation of tumor immunity; integrate findings from cellular, molecular, imaging, genomic, and animal-model platforms; and exercise scientific judgment in selecting methods and interpreting results. The Researcher 3 will contribute substantively to manuscripts, presentations, reports, and grant applications; coordinate work with collaborators and core facilities; and serve as an experienced resource for students and less-experienced research personnel. ## Education and Experience:A PhD in Biochemistry, Immunology, Cell Biology, Molecular Biology, Cancer Biology, Neuroscience, Biomedical Sciences, or a related field is required. The role also requires research experience that meets or exceeds the university's Researcher 3 minimum qualification of a master's degree with three years of relevant experience, or a bachelor's degree with five years of relevant experience. Required experience includes independently planning and conducting complex cellular, molecular, immunological, or translational research; designing controlled experiments; analyzing and interpreting multidimensional data; resolving non-routine technical problems; maintaining rigorous research records; and communicating findings through scientific reports, presentations, manuscripts, or grant materials. Experience with mouse models and animal research procedures is required, including tumor implantation or other surgical models, therapeutic administration, tissue collection, disease or tumor monitoring, and collection of tissues for downstream cellular, molecular, and histologic analysis. Experience investigating macrophage biology, T-cell function, inflammatory signaling, tumor immunology, or neuro-immune interactions is also required. Required technical experience includes mammalian cell culture, primary-cell or tissue isolation, multiparameter flow cytometry, PCR and qPCR, Western blotting, immunofluorescence or confocal microscopy, histology or immunohistochemistry, and quantitative image analysis. Experience training or mentoring students or research personnel and working effectively within multidisciplinary research teams is required. Preferred experience includes CRISPR-Cas9 or related genetic manipulation, single-cell or bulk RNA sequencing, multispectral or bioluminescent imaging, stereotactic procedures, intracranial tumor models, macrophage and T-cell functional assays, mitochondrial or metabolic analysis, and development or evaluation of immunomodulatory therapeutic strategies. A strong peer-reviewed publication record and experience drafting manuscripts and research proposals are preferred. The university requires completion of a background check, and qualified applicants may be asked to complete a pre-employment physical, including a drug screen.## Additional Information:The OSUCCC - James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation's largest public universities. The Pelotonia Institute for Immuno-Oncology (PIIO) is a comprehensive bench-to-bedside research initiative focused on harnessing the body's immune system to fight cancer at all levels, from prevention to treatment and survivorship. The Acharya Laboratory is part of the OSUCCC - James and PIIO. Dr. Acharya's research focuses on developing a comprehensive understanding of the tumor microenvironment to inform integrated therapeutic strategies for cancer.## Location:Biomedical Research Tower (0112)## Position Type:Regular## Scheduled Hours:40## **Shift:**First Shift***Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.***