Research Technician I

Mass General Brigham; Boston (MA); On-site; USD 45,000 - 70,000; Full time

Job summary

An established industry player is seeking a Research Technician I to join their dynamic team at a renowned research center. In this exciting role, you will perform standard laboratory procedures, manage mouse colonies, and conduct molecular biology experiments. The position offers a unique opportunity to contribute to groundbreaking research in wound healing and inflammation while working alongside leading experts in the field. If you are passionate about advancing medical innovations and thrive in a collaborative environment, this role is perfect for you.

Qualifications

• Prior laboratory experience preferred, especially in working with mice.
• Must have technical ability, proficient, and accurate in scientific experimentation.

Responsibilities

• Prepares basic solutions and performs base-level procedures as assigned.
• Conduct analysis of results and assist in procedures with rodent models.
• Attend weekly laboratory meetings and maintain laboratory notebooks.

Skills

Wet Lab Experience

Molecular Biology

Histology/Immunochemistry

Microscopy

Flow Cytometry

Pipetting

Cell and Tissue Culture

RT-PCR

Western Blots

Tissue Processing

Education

Bachelor of Science/Art

Job description

2 weeks ago Be among the first 25 applicants

Site: The General Hospital Corporation

At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.

At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.

Job Summary

The Research Technician I will perform standard laboratory procedures in the laboratory of Dr Marneros at the Cutaneous Biology Research Center/MGH.

Duties include: Mouse colony management and husbandry including Tag and tail, genotyping, and euthanasia and tissue harvest, as well as phenotypic characterization of mouse phenotypes. Other responsibilities will include routine molecular biology, histology/immunochemistry, microscopy and flow cytometry in support of projects in cutaneous biology and immunology.

Our laboratory is investigating molecular mechanisms involved in wound healing, angiogenesis and inflammation.

Qualifications

Our laboratory is investigating molecular mechanisms involved in wound healing, angiogenesis and inflammation.

Wet Lab Experience Required

Please submit your Unofficial Transcript

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Project 1: We investigate the role of proangiogenic factors for wound healing and age-related diseases. We could show that the proangiogenic factor VEGF-A induces oxidative stress and NLRP3 inflammasome activation to promote age-related diseases (Cell Reports, 2013; FASEB J, 2014; EMBO Mol Med, 2016; FASEB J, 2018, eLife, 2020). We use a variety of in vivo and in vitro approaches to investigate a novel pathogenic link between VEGF-A and NLRP3 inflammasome activation.

Project 2: We identified a novel pathway that is critical for epithelial differentiation, especially in the kidney and skin. This new pathway plays a critical role in kidney and skin development (Dev Cell, 2020; Cell Reports, 2021; J Clin Invbest, 2024). We are exploring key novel molecular mechanisms that regulate skin and kidney development, with implications for several skin and kidney diseases.

In summary, our laboratory uses a large number of diverse experimental approaches (human genetics, mouse genetics, chemical screens, in vitro assays, cutting-edge imaging technology) to define novel mechanisms in angiogenesis, wound healing and inflammation. All of our projects have strong translational clinical relevance.

Our laboratory is embedded in a highly productive and well-equipped environment at the Cutaneous Biology Research Center of Massachusetts General Hospital/Harvard Medical School. Cutting-edge technologies are available within our Department and the MGH/Harvard research community.

lab website: https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab

Principal Duties and Responsibililtes

• Prepares basic solutions and performs base-level procedures as assigned (i.e. Pipetting, cell and tissue culture, molecular biology and biochemistry procedure etc).
• There will be routine maintenance work for supporting the laboratory such as general laboratory.
• Perform routine assays, including RT-PCR, western blots, tissue processing, stainings and immunolabeling
• Conduct analysis of results
• Will assist in procedures with rodent models
• Maintain a laboratory notebook
• Attend weekly laboratory meetings and maintains laboratory notebooks.
• Will perform other duties as assigned
  
  

Skills/Abilites

• Must exhibit initiative and is able to work independently when trained.
• Must have technical ability, proficient, and accurate in scientific experimentation.
• Ability to work in a group environment and be of assistance to a number of research projects.
• Excellent written and verbal communication skills
  
  

Education

• Bachelor of Science/Art required
  
  

Experience

• Prior laboratory experience preferred, especially in working with mice.
  
  

Additional Job Details (if Applicable)

Remote Type

Onsite

Work Location

149 Thirteenth Street Building 149

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement

The General Hospital Corporation is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Seniority level

• Seniority level

  Entry level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Hospitals and Health Care

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