Research Scientist - In vitro DMPK

QPS Holdings, LLC; Belgique; On-site; USD 90,000 - 120,000; Full time

Job summary

QPS, LLC in Newark, DE is seeking an experienced scientist for independent study design and in vitro metabolism work. The role includes cell culture, enzyme induction studies, mRNA analysis, and data interpretation while mentoring junior staff.

Candidates should hold a Ph.D. or a Master’s with significant relevant experience and demonstrate strong teamwork and communication skills. This on-site position offers growth opportunities at our Newark facility.

Qualifications

• Understanding experimental design and planning; data collection and analysis software.
• Proven ability to work effectively in a team.
• Excellent oral and written communication skills.
• Ability to make independent decisions.

Responsibilities

• Independently understand, recognize and initiate/prepare study protocols and reports.
• Perform in vitro metabolism studies using S9, microsomes, cytosol and expressed enzymes.
• Perform cell culture and maintain cell lines, prepare cells and conduct metabolic and drug transport studies.
• Conduct enzyme induction studies using fresh/cryopreserved human hepatocytes.
• Isolate and purify mRNA, quantify mRNA by qRT-PCR and determine the enzyme induction status.
• Handle lab work and routine projects simultaneously.
• Prepare data summaries and data interpretation.
• Evaluate significance of data and report findings.
• Supervise, train and/or mentor junior scientists.
• Prepare materials for presentations and publications.

Skills

Experimental design

Data analysis software

Teamwork

Communication skills

Independent decision-making

Education

Ph.D. degree

Master’s degree with ≥ 6 years relevant experience

Job description

Responsibilities

• Independently understand, recognize and initiate/prepare study protocols and reports.
• Independently perform in vitro metabolism studies using S9, microsomes, cytosol and cDNA expressed enzymes.
• Perform cell culture and maintain cell lines, prepare cells and conduct the metabolic as well as drug transport studies.
• Conduct enzyme induction studies using fresh/cryopreserved human hepatocytes.
• Isolate and purify mRNA, quantify mRNA by qRT-PCR and determine the enzyme induction status.
• Simultaneously handle lab work as well as routine projects.
• Prepare data summaries and data interpretation.
• Evaluate significance of data and report findings.
• Supervise, train and/or mentor junior scientists.
• Prepare materials for presentations and publications.

Work Location

• This job will be 100% QPS-office/facility based.

Requirements

• The successful candidate will hold an advanced degree in Analytical Chemistry, Biochemistry, Pharmacology, or related scientific discipline as follows:
  • Ph.D. degree
  • Master’s degree with ≥ 6 years relevant experience
• Understanding of experimental design and planning associated with assigned area, as well as data collection and analysis software.
• Proven ability to successfully work in a team environment.
• Excellent oral and written communication skills.
• Ability to make independent decisions.

Benefits

• Great learning opportunities, especially for those new to the field. Our seasoned professionals are here to support and work with you to explore your learning potential and career goals.
• Structured Career Ladders that provide excellent growth based on your personal aspirations.
• Bonuses and merit increases are a part of the QPS total rewards approach and are linked to individual, team and company performance.
• Solid Benefits package, including Company-matched 401(k), and Company-sponsored Group Life/AD&DD and Short and Long-term Disability Insurance.
• Park-like setting in Newark, Delaware.
• Internal committees designed with the needs and enjoyment of QPS employees in mind.

QPS, LLC is an Equal Employment Opportunity/Affirmative Action Employer. In accordance with federal, state, and local laws, we recruit, hire, promote and evaluate all personnel without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, citizenship status, physical disability, protected veteran status, or any other characteristic protected by law. Job applicants and present employees are evaluated solely on ability, experience, and the requirements of the job. In addition, QPS, LLC is a federal contractor and desires priority referrals of protected veterans.