Research Scientist I/II, Purification Sciences

iambic-therapeutics; San Diego (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Iambic Therapeutics, based in San Diego, seeks an experienced Research Scientist to drive purification and analytical sciences for small-molecule discovery. You will lead SFC/LC purification method development, optimize separations, and support high-throughput QC campaigns to deliver purified compounds and robust analytical data.

You will collaborate with HTE and medicinal chemistry teams, troubleshoot instrumentation, and help scale automation across purification and QC workflows in a

Qualifications

• PhD or MS with substantial experience in small-molecule chromatography purification and method development.
• Experience in preparative SFC with method development, optimization and troubleshooting.
• Strong understanding of chromatographic separation science and high-throughput QC workflows.

Responsibilities

• Develop and execute small-molecule purification strategies using preparative SFC and LC.
• Optimize stationary/mobile phases, gradients, and scale‑up for challenging separations.
• Support high-throughput QC workflows using LC/MS to assess identity, purity and sample quality.
• Collaborate with medicinal chemistry and HTE teams to deliver purified, well-characterized compounds.
• Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance and troubleshooting.

Skills

SFC purification

LC purification

LC/MS

High-throughput workflows

Automation

Analytical QC

Troubleshooting

Data management

AI-driven design-making

Education

PhD in Chemistry/Pharmaceutical Sciences/Chemical Engineering or related

MS in Chemistry (with 7+ years)

BS in related field (with 9+ years)

Tools

Agilent instruments

Shimadzu instruments

Preparative LC

SFC equipment

Automation platforms

Job description

JOB SUMMARY

We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform. A key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands‑on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows. This scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI‑driven design‑make‑test‑learn drug discovery cycle. This position will be based out of our San Diego Headquarters.

KEY RESPONSIBILITIES

• Develop and execute small‑molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization.
• Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale‑up, and fraction collection.
• Develop and support high‑throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality.
• Collaborate with medicinal chemistry and HTE teams to establish fit‑for‑purpose purification and QC strategies and rapidly deliver high‑quality compounds.
• Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root‑cause analysis of chromatography, fluidics, hardware, and software issues.
• Provide hands‑on support for SFC, LC, and LC/MS platforms, including maintenance, system optimization, and vendor coordination.
• Develop and improve automated and high‑throughput purification and QC workflows, integrating sample handling, purification, fraction processing, analytical characterization, and data management.
• Evaluate and implement new chromatography, analytical, automation, and informatics technologies to expand throughput, capacity, and operational efficiency.

QUALIFICATIONS

• Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience.
• Strong hands‑on expertise in small‑molecule chromatographic purification and method development, preferably in a pharmaceutical, biotechnology, CRO, or drug discovery environment.
• Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting; preparative LC experience is strongly preferred.
• Strong understanding of chromatographic separation science and demonstrated ability to independently solve complex purification problems.
• Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, software, and workflow issues.
• Strong understanding of medicinal chemistry and small‑molecule drug discovery, with the ability to translate project needs into effective purification and analytical strategies.
• Excellent scientific problem‑solving, communication, and collaboration skills.

PREFERRED QUALIFICATIONS

• Experience with high‑throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred.
• Experience with automation, high‑throughput workflows, and informatics/data‑management systems is highly desirable.
• Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus.

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical‑stage life‑science and technology company developing novel medicines using its AI‑driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world‑class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best‑in‑class and first‑in‑class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI‑based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, s