Research Scientist/Engineer 3, Zhu Lab

FHLB Des Moines; Seattle (WA); On-site; USD 80,000 - 108,000; Full time

Job summary

The University of Washington invites applications for a Research Scientist/Engineer 3 in the Zhu Laboratory. This role focuses on leveraging microphysiological systems, imaging technologies, and single-cell analyses to study host immune responses against chronic viral infections in human skin.

The RS/E 3 will lead projects, supervise students, analyze data, prepare reports and contribute to grants and manuscripts.

Qualifications

• Bachelor’s degree in Biological Sciences or related field.
• At least four years of experience in mucosal immunology, viral-host interactions, antigen-specific T cell responses.

Responsibilities

• Perform high level research and engineering work, analyze data, compile results and draft reports for awards and contracts.
• Perform wet experiments and digital image data analysis of patient tissue specimens.
• Generate, process and analyze high-parameter multiplex immunofluorescence imaging data.
• Process biopsy tissues, perform library constructions and quality control for single-cell RNA sequencing.
• Develop and optimize research protocols and methodologies; maintain HIPAA-compliant records.

Skills

Mucosal immunology

Viral-host interactions

Antigen-specific T cell responses

Data analysis

Education

Bachelor’s degree in Biological Sciences

Job description

Job Description

The Department of Laboratory Medicine & Pathology has an outstanding opportunity for a Research Scientist/Engineer 3 to join their team.

About this Opportunity

The Research Scientist/Engineer 3 (RS/E 3) in the Zhu Laboratory leverages state-of-the-art microphysiological systems, imaging technologies, and single cell RNA sequencing and spatial transcriptomics to study host immune responses against chronic viral infection in human skin. The RS/E 3 performs various in situ assays and directs students and other trainees to ensure successful completion of the research project. Additionally, the RS/E 3 performs data analysis, generates summary reports, and contributes to manuscript preparation and grant application. This is a full-time day shift position located at the Fred Hutch Cancer Research Center (1100 Eastlake Building). The specific work schedule will be discussed with the hiring manager.

Key Responsibilities

• Research Execution, Experimental Design, and Data Analysis Perform high level research and engineering work, analyze data, compile results and draft reports for incoming research awards and/or contracts. Perform wet experiments and digital image data analysis of patient tissue specimens. Generate, process and analyze high-parameter multiplex immunofluorescence imaging data. Process biopsy tissues, perform library constructions and quality control and generate final products for single-cell RNA sequencing. Perform work accurately, precisely and meet completion deadlines. Analyze experimental data and recommend modifications and follow-up experiments. Review the scientific processes, conduct statistical analysis; present data using graphs and figures. Develop and optimize research protocols and methodologies. Maintain accurate, secure, and HIPAA-compliant records.
• Research Project Leadership, Strategic Planning, and Scholarly Contributions Manage and lead research projects of small to moderate size and scope. Organize, prioritize, and coordinate project activities to meet timelines and milestones. Identify long and short-term goals; initiate research program/projects. Assess feasibility of study goals and provide technical expertise during project development. Collaborate with research teams to develop analytical pipelines for complex immune and spatial biology datasets. Contribute data analyses and technical content for grant applications, scientific manuscripts, presentations, and reports. Conduct literature reviews to support project planning and development. Provide technical guidance and feedback to project collaborators and team members.
• Laboratory Operations, Collaboration, and Administrative Support Participate in laboratory maintenance, equipment management, and inventory control. Maintain documentation and document-control systems. Accommodate schedule changes and support team priorities. Assist with continuity of research operations by supporting colleagues' experiments as needed. Participate in team meetings and collaborative activities. Perform other related duties as assigned to support laboratory objectives.

Required Qualifications

Minimum Qualifications

• Applicants who do not meet these qualifications WILL NOT be forwarded to the Hiring Department.
• Bachelor’s degree in Biological Sciences or related field.
• At least four years of experience in the field of mucosal immunology, viral-host interactions, antigen-specific T cell responses,

Additional Qualifications

• Possesses the knowledge to build microphysiological devices, such as “skin-on-chip” platform for virological and immunological evaluation.
• The ability to generate, process and analyze high-parameter, high content multiplex imaging data.
• Strong written and communication skills.
• Ability to solve problems and troubleshoot.

Preferred Qualifications

• Working experience in immune responses to herpes simplex virus infection is highly desired.
• Highly skilled in laboratory benchwork, such as building skin organoid and microphysiological devices.
• Hands on experience in microfluidics.

About the Department of Laboratory Medicine & Pathology

A regional resource for clinical laboratory services required for innovative patient care, research and educational programs, the Department of Laboratory Medicine & Pathology at UW Medicine combines the sophisticated testing and informatics capabilities of fully accredited laboratories with the resources of an academic institution in its delivery of clinical and anatomic pathology services. Recognized for excellence in clinical training, world-class research initiatives, and a commitment to community service, we serve labs and medical facilities both nationally and internationally. Please visit our website to learn more about our department.

About the UW

Working at the University of Washington provides a unique opportunity to change lives – on our campuses, in our state and around the world. UW employees bring their boundless energy, creative problem-solving skills and dedication to building stronger minds and a healthier world. In return, they enjoy outstanding benefits, opportunities for professional growth and the chance to work in an environment known for its diversity, intellectual excitement, artistic pursuits and natural beauty.

Compensation, Benefits and Position Details

Pay Range Minimum: $80,244.00 annual Pay Range Maximum: $108,000.00 annual Other Compensation: - Benefits: For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/ Shift: First Shift (United States of America) Temporary or Regular? This is a regular position FTE (Full-Time Equivalent): 100.00% Union/Bargaining Unit: UAW Research

UAW Research

About the UW Working at the University of Washington provides a unique opportunity to change lives – on our campuses, in our state and around the world. UW employees bring their boundless energy, creative problem-solving skills and dedication to building stronger minds and a healthier world. In return, they enjoy outstanding benefits, opportunities for professional growth and the chance to work in an environment known for its diversity, intellectual excitement, artistic pursuits and natural beauty.

Our Commitment

The University of Washington is committed to fostering an inclusive, respectful and welcoming community for all. As an equal opportunity employer, the University considers applicants for employment without regard to race, color, creed, religion, national origin, citizenship, sex, pregnancy, age, marital status, sexual orientation, gender identity or expression, genetic information, disability, or veteran status consistent with UW Executive Order No. 81. To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or [e-mail]. Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law. Use the filters or enter keywords in the search box (such as “custodian,” “nursing” or “manager”) to explore available opportunities. To find temporary opportunities, enter “temporary” in the search box. If you are a current UW employee: You must log into Workday and apply internally through the UW Jobs Hub. Looking for faculty, librarian or academic staff positions? Please visit our Academic Jobs site. Looking for student employment? Learn more on our Student Employment site. There are many perks to working for the University of Washington. Learn more about the benefits that could be available to you as a UW employee. Sign up for Job Alerts to be notified about job opportunities at the UW that interest you; you’ll be one of the first to learn when openings become available. You will be asked to create an account if you do not already have one.