Research Fellow - Psychiatry/Stem Cell Lab

Mayo Clinic; Rochester (MN); On-site; USD 67,000 - 79,000; Full time

Benefits offered by this job

Medical plan options

Dental coverage

Vision plan

HSA/FSAs for eligible expenses

Competitive retirement package

Job summary

Mayo Clinic in Rochester, MN, is seeking a highly motivated postdoctoral research fellow for stem cell research in the Department of Psychiatry and Psychology. You will lead iPSC-based disease modeling work focused on alcohol and opioid use disorders, and develop mechanistic hypotheses for experimental validation.

Your role includes writing progress reports and manuscripts, and you may participate in grant applications.

Qualifications

• Must have PhD, MD, or equivalent in a relevant field.
• Proven ability to work independently, supervise others and drive complex projects.
• Experience with basic molecular biology techniques such as gel electrophoresis, Western blotting, qPCR, cloning, CRISPR, virus packaging, iPSC culture, RNA-seq, multi-omics.
• Experience in molecular biology, biochemistry and/or omics techniques; cell culture/iPSC experience is a plus.
• Ability to lead a project and collaborate, with excellent communication skills.

Responsibilities

• Lead a project on human iPSC-based disease modeling and therapeutic development for neuropsychiatric disorders.
• Write progress reports and manuscripts; participate in grant applications.
• Receive training on iPSC generation and maintenance; handle routine iPSC and brain organoid culture; test hypotheses from scRNA-seq data.

Skills

Independence in research

Project leadership

Verbal and written communication

Molecular biology techniques

Cell culture / iPSC work

Education

PhD in biology/neuroscience/pharmacology or related

MD or equivalent doctoral degree

Tools

Gel electrophoresis

Western blotting

qPCR

Molecular cloning

CRISPR editing

Virus packaging

iPSC culture

RNA-seq

Multi-omics

Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

Responsibilities

Dr. Ming-Fen Ho’s lab is looking for highly motivated and productive postdoctoral research fellows for stem cell research projects within the Department of Psychiatry and Psychology at Mayo Clinic, Rochester, MN.

This study is designed to identify novel therapeutics for substance use disorders. We will apply novel network biology approaches, pathway modeling, and simulation computational tools to prioritize potential candidates for functional genomic studies. The approaches we are taking could help us to develop mechanistic hypothesis for experimental validation. Our findings will enhance the general understanding of drug mechanism(s) of action and the underlying the pathophysiology responsible for substance use disorders, thus opening new avenues for discovering novel therapeutic targets for the treatment of substance use disorders.

Dr. Ho’s laboratory has established protocols for differentiating human iPSCs into a variety of cell types, including neurons, astrocytes, and brain organoids, and has developed cellular models and cell therapeutic candidates for diseases including alcohol use disorder, and opioid use disorder.

Basic Education, Experience And Skills Required For Consideration

• The successful applicant should have completed a PhD in biology, neuroscience, pharmacology, or a related field. While ideal candidates should have expertise in one of the following areas, we also appreciate candidates in other fields who are committed to learning new skills and keen to bring their unique expertise to study neuropsychiatric disorders in a collaborative environment.
• Proven ability to work independently, supervise team members and drive complex projects.
• Experience in basic fundamental molecular biology techniques (such as gel electrophoresis, Western blotting, qPCR, molecular cloning, CRISPR editing, plasmid construction, virus packing, iPSC culture, RNA-sequencing, multi-omics studies).
• Experience in molecular biology, biochemistry and / or omics techniques; cell culture / iPSC experience is a plus
• Candidates are expected to lead a project and establish collaborative research and must have excellent verbal and written communication skills.

Key Responsibilities Include

• The postdoctoral fellow will lead a project on human iPSC-based disease modeling and therapeutic development for neuropsychiatric disorders such as alcohol use disorder and opioid use disorder.
• The postdoctoral fellow is expected to write progress reports and high-quality manuscripts for publication. Applying for postdoctoral fellowship and participating in grant applications are encouraged.
• Dr. Ho will provide training for iPSC generation and maintenance, and lab techniques for functional genomic studies. The postdoctoral fellow will be responsible for routine cell culture for iPSCs and brain organoids. The postdoctoral fellow will use the data generated from the scRNA-seq and generate hypothesis and test in the lab. She/he will work closely with Dr. Ho for this grant to pursue the function and mechanisms of genes and pathways identified in the course of this project. She/he will have their own projects and build their bibliography during their postdoctoral training.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

Exemption Status

Exempt

Compensation Detail

$67,282.95 - $78,711.15 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Monday - Friday

Weekend Schedule

as needed

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" . Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Kara Schott