Research Fellow - Orthopedic Surgery - Sammarco lab

Mayo Foundation for Medical Education and Research; Rochester (MN); On-site; USD 67,000 - 79,000; Full time

Benefits offered by this job

Medical plan options

Dental plan options

Vision plan options

Pre-Tax Savings: HSA/FSAs

Competitive retirement package

Job summary

The Sammarco Laboratory in the Department of Orthopedic Surgery at Mayo Clinic seeks a Postdoctoral Research Fellow to study cellular and molecular mechanisms of bone and soft tissue regeneration. The fellow will lead independent projects, apply molecular, cellular, and imaging approaches, and contribute to translational regenerative therapies.

Ideal candidates hold a Ph.D., M.D., or equivalent and have strong training in mammalian cell culture, histology, immunohistochemistry, microscopy, and

Qualifications

• Must have a Ph.D., M.D., or equivalent doctoral degree.
• A Ph.D. in biology, molecular biology, biomedical sciences, developmental biology, regenerative biology, neuroscience, bioengineering, or a related field is preferred.
• Extensive experience in molecular and cellular biology and ability to independently design experiments, troubleshoot, and interpret findings.

Responsibilities

• Independently design, execute, troubleshoot, and interpret complex molecular, cellular, imaging, and mouse-based studies addressing musculoskeletal regeneration questions.
• Generate high-quality, reproducible data using molecular biology, cell biology, histology, imaging, and mouse-based techniques.
• Prepare publication-quality figures, write first-author manuscripts, and contribute to fellowship and grant applications.
• Mentor research staff and trainees and contribute to the lab's scientific vision.

Skills

Molecular biology

Cell biology

Mouse models

Immunohistochemistry

Microscopy

Histology

Data analysis

Experimental design

Mentoring

Education

Ph.D., M.D., or equivalent

Tools

Mammalian cell culture

Histology

Microscopy

Image analysis

Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical:Multiple plan options.
• Dental:Delta Dental or reimbursement account for flexible coverage.
• Vision:Affordable plan with national network.
• Pre-Tax Savings:HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

Responsibilities

The Sammarco Laboratory in the Department of Orthopedic Surgery at Mayo Clinic is seeking an outstanding and highly motivated Postdoctoral Research Fellow to join a growing research program investigating the cellular and molecular mechanisms that regulate bone and soft tissue regeneration. Our laboratory seeks to understand how fundamental cellular processes direct regenerative healing, with the long-term goal of translating these discoveries into therapies that improve musculoskeletal repair and functional recovery.

Our research integrates molecular biology, regenerative biology, and advanced imaging to investigate fundamental mechanisms of tissue regeneration. Current areas of investigation include cellular metabolism, mitochondrial homeostasis and remodeling, reactive oxygen species (ROS) signaling, sensory nerve regulation of bone regeneration, cellular senescence, and the molecular pathways that distinguish regenerative healing from fibrosis. Together, these studies aim to identify biological mechanisms that can be translated into innovative regenerative therapies.

The successful candidate will join a collaborative, multidisciplinary laboratory committed to scientific rigor, innovation, and discovery. We seek an intellectually curious scientist capable of leading independent research projects while contributing to the laboratory's broader scientific vision. This position offers an outstanding opportunity to develop innovative research, publish high-impact studies, compete for extramural funding, and prepare for a successful career as an independent investigator.

Responsibilities

The Postdoctoral Research Fellow is expected to independently design, execute, troubleshoot, and interpret complex molecular, cellular, imaging, and animal-based studies addressing fundamental questions in musculoskeletal regeneration. The fellow will develop scientific hypotheses, optimize and establish new experimental approaches, critically evaluate data and the literature, and identify new research directions that advance the laboratory's mission.

The fellow is expected to generate high-quality, reproducible data using advanced molecular biology, cell biology, histology, imaging, and mouse-based techniques. Additional responsibilities include analyzing complex datasets, preparing publication-quality figures, writing first-author manuscripts, contributing to fellowship and grant applications, and presenting research at laboratory meetings and regional, national, and international scientific conferences.

The fellow will contribute intellectually to the laboratory's research program by mentoring research staff and trainees, fostering scientific rigor and reproducibility, supporting collaborative projects, and helping shape the future direction of the laboratory.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree. A Ph.D. in biology, molecular biology, biomedical sciences, developmental biology, regenerative biology, neuroscience, bioengineering, or a related field is preferred. Candidates should demonstrate a strong record of scientific productivity through peer-reviewed publications reflecting the ability to independently conduct rigorous research.

Candidates must possess extensive experience in molecular and cellular biology and demonstrate the ability to independently design experiments, troubleshoot complex methodologies, and interpret findings within a broader biological context. Experience with mammalian cell culture, mouse models, histology, immunohistochemistry, microscopy, quantitative image analysis, and advanced molecular techniques is highly desirable.

The successful candidate will possess excellent written and verbal communication skills, with demonstrated experience preparing publication-quality figures, writing scientific manuscripts, and presenting research to diverse scientific audiences. Experience writing fellowship applications or contributing to grant proposals is preferred.

Candidates should demonstrate scientific creativity, intellectual curiosity, exceptional organizational skills, and the ability to manage multiple concurrent projects. They must be highly self-motivated, capable of working independently within a collaborative multidisciplinary environment, and committed to the highest standards of scientific rigor, reproducibility, and integrity. Strong leadership and mentoring skills are expected.

Applications submitted without a cover letter describing research interests, career goals, and motivation for joining the laboratory will not be considered.

Exemption Status

Exempt

Compensation Detail

$67,282 - $78,711/ year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Varies

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'. Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.