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Research Bioinformatician II - Abreu Lab - Inflammatory Bowel Disease Institute
Cedars-Sinai
Los Angeles (CA)
On-site
USD 78,000 - 134,000
Full time
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Job summary
Cedars-Sinai is seeking a Research Bioinformatician II to join the Abreu Lab, focusing on inflammatory bowel diseases. The role involves bioinformatics analysis, data management, and collaboration with researchers to advance understanding of gut health. Candidates should have a strong background in bioinformatics and experience with genomic data analysis.
Qualifications
- 3 years experience in research environment with algorithms and scientific computing.
- Experience in manipulating large genomic datasets.
- Familiar with public genomic databases.
Responsibilities
- Provides bioinformatics analysis support for omic projects.
- Develops and maintains software pipelines for genomic analysis.
- Collaborates with biologists and clinicians on research objectives.
Skills
Education
Tools
Job description
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Job Description
to join the team!
The Abreu Lab team focuses on ways to prevent and treat inflammatory bowel diseases (IBD) and inflammatory colon cancer. We seek to understand how the relationship between a patient’s immune system and their gut microbes may lead to gut inflammation or even the development of tumors. Our research also explores how the host-gut microbe relationship is influenced by environmental and genetic factors, including the impact of diet. To learn more, please visit Abreu Lab | Cedars-Sinai.
Job Description
Dr. Maria Abreu is seeking a Research Bioinformatician II to join the team!
The Abreu Lab team focuses on ways to prevent and treat inflammatory bowel diseases (IBD) and inflammatory colon cancer. We seek to understand how the relationship between a patient’s immune system and their gut microbes may lead to gut inflammation or even the development of tumors. Our research also explores how the host-gut microbe relationship is influenced by environmental and genetic factors, including the impact of diet. To learn more, please visit Abreu Lab | Cedars-Sinai.
Are you ready to be a part of breakthrough research?
The Research Bioinformatician II performs general bioinformatics analysis and software support for projects involving in omics, and interacts with investigators to identify research problems, find appropriate software tools, and recognize national biological databases and online resources for omic data. The RBII manages omic data including loading and querying data from database system(s) and public repositories, and transforms and merges multilevel omic data into user-friendly formats. The RBII assists in development, testing, and maintenance of modular software pipelines, provides bioinformatics data analysis, preliminary interpretation of the data, and reports of the results for possible publications. The Research Bioinformatician II also works with bioinformatics faculties to determine future bioinformatics needs, and helps to develop tools and pipelines as necessary to keep pace with rapid advances in sequencing technology. The Bioinformatician II demonstrates continuous self-improvement, makes effective contributions to the section, and adheres to the Cedars-Sinai compliance plan, code of conduct, and hospital and departmental policies and procedures.
Primary Job Duties and Responsibilities:
- Provides general bioinformatics analysis support for omic projects. Responsible for data analysis and software compilations including next generation sequence alignment, polymorphism identification, expression analysis, and visualization tools and browsers.
- Summarizes data analyses results in the form suitable as the basis for the first draft of written reports, and makes preliminary interpretations of the data.
- Develops, tests, and maintains modular software pipelines for genome sequencing, assembly, annotation, metagenomic analysis, and genotyping using high-throughput sequencing platforms including 454, Illumina, and Pacific Biosciences.
- Manages data including loading and querying data from database systems, downloading omic data from public repositories, and transforming data to the necessary formats.
- Provides solutions for investigator’s problems through data mining and extraction.
- Identifies, evaluates, and incorporates relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology.
- Assists and/or collaborates in preparation of grant proposals, publications, and presentations involving omic data.
- Helps develop tools and pipelines as necessary to keep pace with rapid advances in sequencing technology.
- Educates others about bioinformatics through mentoring of and teaching colleagues, investigators, fellows, and graduate students.
- Process and analyze next-generation sequencing (NGS) data and genomic datasets.
- Use CLC Genomics Workbench for sequence alignment, variant calling, and subsequent data analysis.
- Develop and implement scalable data processing workflows on AWS (Amazon Web Services).
- Integrate and analyze data from public research databases such as GEO, ENA, TCGA, and dbGaP.
- Perform quality control (QC), preprocessing, and annotation of genomic data.
- Conduct statistical and computational analyses to interpret genomic variations and insights.
- Collaborate with biologists, clinicians, and data scientists to advance research objectives.
- Create detailed reports, visualizations, and documentation of analytical findings.
- Stay current with emerging tools and methodologies in genomic data analysis.
Education:
- Bachelor's of Science Degree in Computer Science, Electric Engineering, Computational biology, or Bioinformatics, or Master of Science/ Engineering in relevant fields (e.g. Biology with strong quantitative training, biostatistics with concentration in bioinformatics). Master's degree preferred.
- Three (3) years of experience in research environment including developing working knowledge in algorithms, scientific computing, and machine learning or statistics.
- Three (3) years of experience in manipulating, analyzing, and annotating very large genomic (e.g. NGS) data sets both in exploratory and pipelined fashions.
- Familiar with C/C++, Java, Perl, python, and the Unix (Linux) environment.
- Proficiency in CLC Genomics Workbench for NGS data analysis.
- Experience with AWS cloud computing for large-scale genomic data processing.
- Strong coding skills in Python, R, or Bash for bioinformatics workflows.
- Familiarity with public genomic and research databases (GEO, ENA, TCGA, dbGaP, etc.).
- Expertise in NGS pipelines (e.g., RNA-Seq, WGS, WES, metagenomics).
- Knowledge of genetic variation analysis, population genetics, and annotation tools.
- Familiar with medical and biological terminologies, bioinformatics resources, and national biological databases.
- Previous experience with inflammatory bowel disease (IBD) research is highly desirable.
Cedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents.
About The Team
Cedars-Sinai is one of the largest nonprofit academic medical centers in the U.S., with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Choose this if you want to work in a fast-paced environment that offers the highest level of care to people in the Los Angeles that need our care the most.
Req ID : 8052
Working Title : Research Bioinformatician II - Abreu Lab - Inflammatory Bowel Disease Institute
Department : Research - Digestive and Liver Diseases
Business Entity : Cedars-Sinai Medical Center
Job Category : Academic / Research
Job Specialty : Bioinformatics
Overtime Status : EXEMPT
Primary Shift : Day
Shift Duration : 8 hour
Base Pay : $78,332.80 - $133,161.60
- Seniority levelNot Applicable
- Employment typeFull-time
- Job functionResearch, Analyst, and Information Technology
- IndustriesHospitals and Health Care, IT Services and IT Consulting, and Research Services
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