Research Associate - tRNA and mRNA Biology

Scismic; Cambridge (MA); On-site; USD 80,000 - 120,000; Full time

Job summary

A biotech startup in Cambridge, MA is seeking an expert scientist in cellular neurobiology to establish cellular assays for proof of concept in tRNA therapeutic leads. The role demands hands-on experience with various molecular techniques and the ability to work independently as well as collaboratively in a fast-paced environment. Candidates with a BS/MS in relevant fields and exceptional organizational skills are encouraged to apply.

Qualifications

• Experienced in isolating neurons and establishing cultures.
• Hands-on skills in qPCR, western blotting, microscopy, and calcium imaging.
• Ability to prioritize and manage multiple tasks effectively.

Responsibilities

• Establish in vitro disease models using primary neurons and glia.
• Design and execute cell-based assays for therapeutic leads.
• Conduct literature searches and communicate findings internally.

Skills

Cell culture techniques

Molecular biology techniques

Cellular biology

Excellent communication skills

Education

BS/MS in Neurobiology, Molecular/Cellular Biology, or related discipline

Job description

Scismic is supporting the growth of a Cambridge, MA biotech startup that is pioneering mRNA-modulating therapies to cure a broad range of genetic diseases. The company is exploring the use of its novel platforms in neurological disorders, heart disease, and muscular dystrophies.

Position summary:

As an expert scientist in cellular neurobiology, you will be responsible for establishing cellular assays to demonstrate in vitro proof of concept for company tRNA therapeutic leads and characterize the cellular activity and downstream disease-relevant biology to help prioritize candidates for in vivo studies.

Key responsibilities for this position include:

• Establish in vitro disease models in relevant cell types including primary neurons and glia isolated from transgenic animal models and patient-derived iPSC lines.
• Design, troubleshoot, and execute cell-based assays in human and rodent cell lines to characterize the efficacy and safety of company's novel tRNA therapeutic leads.
• Understand mechanism of action of lead candidates and establish assays and endpoints relevant to downstream target and disease biology. Conduct literature searches; communicate understanding in internal forums and with external collaborators and partners.

Minimum qualifications:

• A BS/MS in Neurobiology, Molecular/Cellular Biology, physiology, or a related discipline.
• Extensive hands-on experience with a variety of molecular, cellular and/or physiological techniques (isolating rodent neurons and establishing primary neuronal cultures, neurite outgrowth, qPCR, western blotting, microscopy, calcium imaging, synaptic imaging, multi-electrode arrays, human IPS/ES cell culture, etc).
• Prior experience using AAV/lentivirus in primary or iPSC-derived neurons is highly desirable.
• Ability to master new concepts and technologies quickly and run experiments independently.
• Scientifically rigorous, highly organized, with excellent oral and written communication skills.
• Ability to work independently as well as collaborate with colleagues and effectively prioritize and manage multiple tasks in a fluid, fast-paced work environment

Title commensurate with level of experience.

We are accepting applications to build a pipeline of potential candidates for future opportunities. If your qualifications align with our requirements, we will contact you once the hiring process begins. Thank you for your interest in this role.