Research Associate, Oligonucleotide Discovery

Lensa; Watertown (MA); On-site; USD 65,000 - 80,000; Full time

Job summary

A prominent biotechnology company in Watertown is seeking a Research Associate to join its Genetic Medicines team. This role involves innovating new assays, executing in vitro and in vivo experiments, and collaborating with partners to drive drug discovery. Candidates should hold a B.S. or M.S. in Biology, with relevant experience in biotech or pharma. Competitive compensation and comprehensive benefits are offered, including unlimited PTO and generous medical coverage.

Benefits

Unlimited PTO

401(k) company match

Generous health benefits

Annual stipend for continuing education

Employee Assistance Program (EAP)

Qualifications

• 1 to 3 years of experience in biotech/pharma is highly desirable.
• Knowledge of antisense oligonucleotide modalities.
• Experience in designing and running various biological assays.

Responsibilities

• Design and execute molecular biology and protein techniques.
• Collaborate on drug discovery projects.
• Maintain accurate records of experiments.

Skills

Molecular biology techniques

Protein assays

Cell culture

Data analysis

Education

B.S. or M.S. degree in Biology or related science

Job description

5 days ago Be among the first 25 applicants

Lensa is the leading career site for job seekers at every stage of their career. Our client, Alloy Therapeutics, is seeking professionals in Watertown, MA. Apply via Lensa today!

The Company

We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions.We strive to have workers in the office when needed to interact organically and face-to-face.Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year.We respect and value our colleagues for their hard work that requires them to be in the lab every day.We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility.We are all one team!

The Team

The Alloy Genetic Medicines group is innovating a novel RNA-based drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. The team works closely with external partners to discover and develop AntiClastic Genetic Medicines.

The Role

As a Research Associate, you will work within the Genetic Medicines team in Waltham, MA. You will also collaborate with internal/external partners on nucleic acid drug discovery projects to ensure timely execution of the experiments, and delivery of high-quality data. This role will have an autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.

This role will report to Senior Scientist with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.

How You’ll Drive Impact

• Innovate: Develop novel assays to elucidate the mechanism of action of novel ASO formats.
• Deliver: Design, execute, analyze, and interpret in vitro and in vivo experiments. Generate robust, high-quality data.
• Collaborate: Work closely with internal/external partners on drug discovery projects to ensure studies are executed to meet scientific goals and timelines.
  
  

Principal Responsibilities

• Design and execute several molecular biology and protein techniques including, but not limited to, nucleic acid isolation, RT-qPCR, western blots and ELISA.
• Culture various cell types including established cell lines, primary cells and iPSCs.
• Perform a range of cell-based assays, including those utilizing microscopy and plate readers for fluorescence/luminescence detection.
• Process mouse tissue for nucleotide extraction and downstream analysis.
• Operate high-throughput tools, including 96 channel electronic pipets to streamline and enhance experimental workflows.
• Analyze data using GraphPad software and prepare presentation-ready images to effectively communicate experimental findings.
• Maintain comprehensive and accurate records of all experiments using the Benchling electronic notebook, ensuring meticulous documentation and data integrity.
  
  

Qualifications

• B.S. or M.S. degree in Biology or related science.
• 1 to 3 years of additional experience in biotech/pharma.
• Knowledge of antisense oligonucleotide modalities and their mechanism of action. Previous Experience working with ASOs is highly desirable.
• Experience designing and running molecular biology, protein and cell-based assays.
  
  

Taking Care of Our People

We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.

Compensation

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match
  
  

Health & Family

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
  
  

Unique Perks

• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
  
  

Pay Transparency

At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $65,000 - $80,000 with the final offer based on factors like your experience, skills, and alignment with our needs.

Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.

We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [e-mail] . We will make every effort to respond to your request for disability assistance as soon as possible.

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  Entry level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  IT Services and IT Consulting

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