Research Associate II, Translational Science & Biomarkers

ImmunEdge; Redwood City (CA); On-site; USD 77,000 - 116,000; Full time

Benefits offered by this job

Annual bonus

Equity

Health insurance (employee + family)

401k plan

FSA plans

Employee Assistance Plan

Paid time off

Job summary

ImmunEdge is seeking a Research Associate II in Histology/IHC to join the Translational Science & Biomarkers team in Redwood City. The role focuses on FFPE sectioning, IHC/ISH staining, H&E, and multiplex workflows, with independent management of experiments under scientists and cross-functional collaborators.

The candidate will handle automated stainers/scanners, maintain records, and contribute to assay development, validation, and day-to-day histology operations.

Qualifications

• HT or HTL (ASCP) certification or eligibility.
• Bachelor's degree in biology, chemistry, or related discipline.
• 2+ years of histology and IHC experience in an R&D, translational science, or clinical lab setting.
• On-site work required and ability to perform repetitive fine-motor tasks.
• Proficiency in routine histology techniques: fixation, processing, embedding, microtomy, H&E, IHC, slide QC, and slide scanning.
• Hands-on with automated IHC stainers and scanners (e.g., Leica BOND, Ventana BenchMark, Dako Link48, Zeiss Axioscan).
• Ability to manage multiple experiments with strong attention to detail and records.
• Follow written protocols, learn new methods, troubleshoot, and communicate issues clearly.
• Familiarity with normal tissue morphology and tumor histology preferred.
• Experience IHC for immune cell markers, multiplex IHC, and immunofluorescence preferred.
• QIHC (ASCP) qualification a plus, digital pathology/image analysis (HALO/Visiopharm) a plus.
• Experience with cell culture and preparation of cell-based controls for IHC/ISH a plus.
• Experience with western blot and flow cytometry a plus.

Responsibilities

• Independently prepare and section FFPE blocks using a microtome for high-quality sections.
• Independently perform single-plex and multiplex IHC/ISH staining, H&E, and whole-slide scanning.
• Develop, optimize, and validate singleplex and multiplex IHC/ISH assays.
• Maintain routine cleaning and maintenance of microtomes, automated stainers, and scanners.
• Monitor supplies, track expirations, and keep a clean, inspection-ready lab.
• Collaborate with scientists, pathologists, and cross-functional teams while managing multiple experiments and timelines.

Skills

Attention to detail

Team collaboration

Documentation

Troubleshooting

Manual dexterity

Education

Bachelor's degree in biology, chemistry, or related

Tools

Leica BOND

Ventana BenchMark

Agilent Dako Link48

Zeiss Axioscan

Job description

Job Title

Research Associate II, Histology/IHC

Location

Redwood City

Company Overview

ImmunEdge is a biopharmaceutical company committed to developing novel therapeutics for patients with serious or life-threatening diseases. With a highly experienced team of experts in immunology and drug development, we are pioneering innovative approaches to target and modulate key molecular pathways that regulate the immune response.

At ImmunEdge, we are driven by a shared commitment to improving human health through innovative science. We are building a culture based on kindness, collaboration, and a deep passion for advancing science. As an early joiner to the company, you will help cultivate an environment where every team member is encouraged to challenge ideas, think critically, and contribute their unique perspectives. We value openness, transparency, and continuous learning, and want to empower our employees to take ownership of their work while fostering a sense of community and teamwork. Whether you're working in the lab, the office, or across functional teams, you will find an inclusive space where your contributions matter and your professional growth is supported.

Join us in shaping the future of biotechnology. Together, we can change lives.

Position

The Research Associate II will join the Translational Science & Biomarkers team, which supports preclinical and clinical programs through the discovery, development, and validation of biomarkers that inform mechanism of action, indication selection, patient stratification, and clinical development strategy. ImmunEdge is seeking a histology technician or technologist with strong hands-on experience in microtomy and immunohistochemistry (IHC). This is a bench-focused role for a histology professional who can independently section formalin-fixed, paraffin-embedded (FFPE) specimens and execute routine H&E, IHC, and ISH workflows. Working under the direction of scientists, the Research Associate II will independently manage assigned experiments, contribute to assay optimization and validation, maintain accurate sample and study records, and help ensure reliable day-to-day operation of histology and IHC workflows.

Key Responsibilities

Independently prepare and section FFPE cell and tissue blocks, including tumor specimens, using a microtome to produce consistently high-quality sections.

Independently perform single-plex and multiplex IHC and ISH staining, H&E staining, and whole-slide scanning using established protocols.

Execute and contribute to the development, optimization, and validation of singleplex and multiplex IHC and ISH assays for routine and novel targets.

Perform routine cleaning and maintenance of microtomes, automated stainers, scanners, and related equipment.

Monitor supplies and reagent inventory, track expiration dates, and help maintain a clean, safe, and inspection-ready laboratory.

Collaborate with scientists, pathologists, research associates, and cross-functional teams while managing multiple assigned experiments and timelines.

Qualifications

HT or HTL (ASCP) certification or eligibility; candidates without certification may be considered based on relevant hands-on experience.

Bachelor's degree in biology, chemistry, or a related discipline, or an equivalent combination of education and relevant laboratory experience.

2+ years of relevant histology and IHC experience in an R&D, translational science, or clinical laboratory setting.

Ability to work on site and perform repetitive fine-motor tasks associated with sectioning, staining, and slide-scanning workflows.

Demonstrated proficiency in routine histology techniques, including fixation, processing, embedding, microtomy, H&E and IHC staining, slide quality control, and slide scanning.

Hands-on experience with automated IHC stainers and scanners, such as Leica BOND, Ventana BenchMark, Agilent Dako Link48, and Zeiss Axioscan.

Demonstrated ability to independently organize and execute multiple assigned experiments while maintaining strong attention to detail and recordkeeping.

Ability to follow written protocols, incorporate technical feedback, learn new methods, troubleshoot routine technical issues, and communicate problems clearly.

Basic familiarity with normal tissue morphology and common tumor-associated histologic features is preferred.

Experience performing IHC for commonly used immune cell markers is preferred.

Experience with multiplex IHC and immunofluorescence is preferred.

QIHC (ASCP) qualification is a plus.

Experience with digital pathology and image analysis software, such as HALO or Visiopharm, is a plus.

Experience with basic cell culture and the preparation of cell-based controls for IHC and ISH is a plus.

Experience with western blot and flow cytometry is a plus.

Expected Salary Range

$77,360 - $116,040

We encourage candidates of all levels to apply as there is sometimes flexibility on job level and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity, and location.

ImmunEdge offers a competitive employment package that includes an annual bonus plan, equity, and a generous benefits package including comprehensive health (medical, dental, and vision) insurance for our employees and their families, a 401k plan, FSA plans (medical, dependent), an Employee Assistance Plan, and a holiday and paid time off plan.

At ImmunEdge, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. ImmunEdge will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.