Research Associate II/Senior Research Associate, Oligonucleotide Foundry Somerville, Massachuse[...]

Tessera Therapeutics, Inc.; Mississippi; On-site; USD 50,000 - 90,000; Full time

Job summary

An innovative biotechnology firm is seeking a skilled individual to join their team in a fast-paced environment focused on Gene Writing technology. This role involves learning and implementing purification strategies for complex oligonucleotides, conducting research, and preparing methods for larger-scale manufacturing. You will have the chance to collaborate with cross-functional teams and present your findings, making strong communication skills essential. If you're passionate about overcoming challenges and contributing to groundbreaking advancements in genetic medicine, this opportunity is perfect for you.

Qualifications

• BS/MS in relevant fields with experience in downstream processing.
• Strong understanding of purification strategies for oligonucleotides.

Responsibilities

• Conduct research into purification strategies and prepare methods for cGMP manufacturing.
• Participate in cross-functional teams and document results.

Skills

Downstream processing of oligos

Buffer preparation for purification

Lab instrument maintenance (AKTA, UF, HPLC, LC-MS)

Analytical instruments (Agilent, Waters)

Documentation using ELNs

Education

BS in Chemistry or Biology

MS in Chemistry or Biology

Tools

AKTA purifiers

HPLC

LC-MS

Agilent instruments

Waters instruments

Job description

Somerville, Massachusetts, United States

Minimum Qualifications:

1. BS with 2+/MS with 1+ years of relevant experience in chemistry, biology, or related life sciences
2. Excellent knowledge and thorough understanding of downstream processing of oligos
3. Experience in preparing buffers for purification and maintaining lab instruments such as AKTA purifiers, UF, HPLC and LC-MS
4. Experience using Agilent and Waters analytical instruments for purity analysis
5. Detail and results oriented with experience using ELNs to document experiments and results

You are interested in…

1. Learning and implementing purification strategies for complex oligonucleotides
2. Conducting research into alternate purification strategies
3. Preparing transfer of methods to larger-scale cGMP manufacturing environment
4. Performing routine operations for critical technology components
5. Participating in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing

About you:

You are a skilled individual who can operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team. You will have the opportunity to organize and present results within the group and interface with other teams, so strong communication skills are critical. You enjoy overcoming challenges in collaboration with colleagues.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.

Recruitment & Staffing Agencies: Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.