Research Associate II, Product Development

CHEManager International; Durham (NC); On-site; USD 55,000 - 75,000; Full time

Benefits offered by this job

NGS library prep (preferred)

Job summary

AskBio Inc., a Bayer group entity, seeks a Research Associate II in RTP, NC to support early cardiovascular programs. You will perform a broad range of molecular biology and protein analyses to drive preclinical gene therapy research and data delivery with growing independence.

Ideal candidates have mammalian cell culture experience, qPCR/ddPCR, ELISA, and Western blot skills, with a strong emphasis on documentation and reproducible data.

Qualifications

• Molecular biology techniques including DNA/RNA isolation and qPCR/ddPCR.
• Experience with mammalian cell culture and aseptic technique.
• Ability to follow established protocols and deliver reliable results.

Responsibilities

• Support design, planning and execution of experiments for protein, RNA and DNA from in vitro/in vivo studies.
• Perform a broad range of techniques independently to support platform and therapeutic programs.
• Maintain accurate electronic lab notebook records and manage sample inventories.
• Contribute to assay/workflow improvements and data analysis.
• Prepare study reports and aid in study protocol development.
• Ensure lab areas are clean, safe and well organized; assist in equipment maintenance.
• Coach peers and share best practices to enable efficient daily workflow.

Skills

Mammalian cell culture

Molecular biology techniques

Data collection & documentation

Education

MS in Molecular Biology/Biochemistry or related field

BS with 2+ years relevant lab experience

HS diploma with 6+ years relevant lab experience

Tools

qPCR/ddPCR

ELISA

SDS-PAGE

Western blot (Jess)

NGS library prep (preferred)

Job description

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson's disease, and Pompe disease. AskBio's gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.

Our vision

Pioneering science to create transformative molecular medicines.

Our mission

Lead innovative science and drive clinical outcomes to transform people's lives.

Our Principles

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

Our Values

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Position Summary

The Research Associate II is a technical role utilizing a broad range of experimental techniques to support platform, therapeutic pipelines, and R&D activities, with a primary focus on early cardiovascular programs. The RA II will perform optimization, development, and data delivery with increased independence, supporting key preclinical studies in gene therapy R&D. This position is office-based based in RTP, NC and reports to the Senior Scientist, Product Development.

The Ideal Candidate Will Have

• Direct expertise with mammalian cell culture, including primary and immortalized cell systems, and strong aseptic technique
• Direct experience with quantitative molecular biology techniques, including isolation of DNA, RNA, and protein from cells and tissues; quantitative PCR and RT-PCR (preference for direct experience with ddPCR); ELISA; SDS-PAGE; and Western blot/automated Western (e.g., Jess)
• Strong data collection, documentation, and reporting skills, with the ability to work independently and as part of a research team

Job Responsibilities

• Support scientists in the design, planning, and execution of experiments to analyze protein, RNA, and DNA from in vitro and in vivo studies, contributing to key studies in gene therapy R&D
• Perform a broad range of experimental techniques independently (e.g., cell culture, nucleic acid and protein extraction, qPCR/RT-qPCR/ddPCR, ELISA, SDS-PAGE, Western blot/Jess, and related assays) to support platform and therapeutic programs
• Process, track, and analyze large numbers of samples in parallel while maintaining high quality and consistency in assay execution
• Maintain accurate, up to date records of all experimental work in electronic lab notebooks; support maintenance of databases, sample inventories, and reagent inventories as needed
• Assist in the development and optimization of experimental protocols; contribute to assay and workflow improvements
• Generate high quality, reproducible data and contribute to data analysis, interpretation, and presentation
• Contribute to and/or author study reports and study protocols
• Ensure laboratory areas are clean, safe, and well organized; monitor and restock common reagents and supplies; support proper operation and routine maintenance of equipment; and adhere to all safety and compliance guidelines
• Help coach and support peers within the workgroup (e.g., sharing best practices, cross training on internal assays) to enable effective day-to-day workflow

Minimum Requirements

• MS in Molecular Biology, Biochemistry or related field; or BS degree in Molecular Biology, Biochemistry or related field with 2+ years' relevant laboratory experience; or High School Diploma with 6+ years' relevant laboratory experience
• Hands-on experience with molecular biology techniques, including DNA/RNA isolation, SDS-PAGE, qPCR/ddPCR, and Western blot
• Prior experience with mammalian cell culture and aseptic technique
• Ability to follow established protocols with minimal supervision and deliver reliable, reproducible results

Preferred Education, Experience And Skills

• Experience in NGS library production and sequencing is highly desired
• Comfort working across diverse experimental workflows and learning new techniques as project needs evolve

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job-related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at [phone] or sending us an email at [e-mail].