Research Associate II - Integrative Genomics Core

City of Hope; Duarte (CA); On-site; USD 45,000 - 65,000; Full time

Benefits offered by this job

Comprehensive Benefits

Collaborative research environment

Job summary

City of Hope’s Beckman Research Institute seeks a Research Assistant II to support integrative genomics workflows, including NGS library prep, nucleic acid extraction, and QC. The role operates within a collaborative core facility leveraging Illumina, PacBio, Nanopore, and 10x Genomics platforms.

The successful candidate will perform extractions, library prep, high-throughput workflows, and meticulous record-keeping while contributing to method development under supervision of core scientists.

Qualifications

• Bachelor’s degree in molecular biology or related field; Master’s preferred.
• 2+ years in molecular biology or genomics with required degree.
• Experience with PCR, qPCR and nucleic acid handling.
• 2+ years direct experience with NGS library prep preferred.
• Familiarity with Illumina sequencing platforms.
• Experience with long-read sequencing and single-cell workflows (10x Genomics)

Responsibilities

• Perform DNA and RNA extraction, quantification, and QC.
• Prepare libraries for NGS using Illumina, PacBio, and 10x Genomics.
• Execute high-throughput workflows with emphasis on quality.
• Track samples and metadata with FileMaker LIMS.
• Maintain accurate lab records per core facility standards.
• Assist in method development and validation of new workflows.
• Communicate sample requirements, project status, and results with scientists.

Skills

Molecular biology

Genomics

Laboratory techniques

Data management

Education

Bachelor's degree in molecular biology or related field

Master's degree preferred

Tools

Illumina sequencing

PacBio sequencing

10x Genomics

FileMaker

Job description

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

We are seeking a highly motivated Research Assistant II to join the Integrative Genomics Core. You will support a wide range of genomics workflows, including next-generation sequencing (NGS) library preparation, nucleic acid extraction, and quality control processes.

The Integrative Genomics Core provides comprehensive genomics services to support cutting‑edge biomedical research. Leveraging advanced platforms such as Illumina, PacBio, Nanopore, and 10x Genomics, the core enables a broad range of genomic and epigenomic applications. These technologies empower investigators to explore complex biological systems, from cancer genomics to translational and precision medicine studies, within a highly collaborative, service‑oriented environment.

As a successful candidate, you will:

• Perform DNA and RNA extraction, quantification, and quality control
• Prepare libraries for next-generation sequencing using Illumina, PacBio (SMRT sequencing), and 10x Genomics platforms
• Execute high-throughput workflows with attention to consistency and quality
• Track samples and metadata using laboratory information management systems FileMaker
• Maintain accurate and detailed laboratory records in accordance with core facility standards
• Assist in method development, optimization, and validation of new genomics workflows under supervision of core scientists
• Communicate effectively with core scientists regarding sample requirements, project status, and results

Your qualifications should include:

• Bachelor’s degree in molecular biology, Genetics, or related field. Master’s degree preferred.
• 2+ years of related experience in molecular biology or genomics with a Bachelor’s degree or 1+ year related experience with a Master’s degree.
• Experience with standard molecular biology techniques (PCR, qPCR, nucleic acid handling)
• 2+ years of Direct experience with next-generation sequencing library preparation is preferred
• Familiarity with Illumina sequencing platforms.
• Experience with long‑read sequencing (PacBio) and/or single‑cell or spatial genomics workflows (10x Genomics)

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.