Research Associate II, High-Throughput Screening

CAMP4 Therapeutics; Cambridge (MA); On-site; USD 85,000 - 110,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) plan with company contribution

Employee Stock Purchase Program

Paid parental leave

Tuition assistance

Job summary

CAMP4 Therapeutics is seeking a Research Associate II for High-Throughput Screening in Cambridge, MA. You will execute and optimize in vitro screens, manage cell models (including iPSC-derived), and generate molecular data to support ASO discovery.

Collaboration with Discovery, Chemistry, and Data Science teams is essential, with a focus on precision and throughput. The role emphasizes automation, careful experimental design, and data-driven decisions to advance potential CNS-targeted ASO

Qualifications

• BS or MS in molecular biology, biochemistry, cell biology, bioengineering or related field.
• 3+ years with BS or 1+ year with MS; biotechnology/pharma experience preferred.
• Hands-on mammalian cell culture and cell-based assays experience.
• Molecular biology techniques including RNA isolation, qPCR, and western blotting.
• Demonstrated careful execution, thorough documentation, and reproducible results.
• Preferred experience with liquid-handling automation and high-throughput screening.
• Experience with oligonucleotide therapeutics (ASOs) a plus.

Responsibilities

• Plan and execute high-throughput in vitro screens to identify ASO candidates.
• Operate liquid-handling platforms with emphasis on accuracy and throughput.
• Culture, maintain, and manipulate various cell models including iPSC-derived cells.
• Perform RNA isolation, qPCR, dPCR, and protein-based readouts.
• Analyze screening data and communicate results to cross-functional teams.
• Develop and transfer screening assays and data quality controls.
• Collaborate with Platform, Discovery, Chemistry, and Data Science teams.
• Maintain detailed records of designs, results, inventories, and data files.

Skills

Mammalian cell culture

Cell-based assays

RNA isolation

qPCR

dPCR

Western blotting

Automation/Liquid-handling

Data analysis

Microsoft Office / GraphPad / R

Education

BS or MS in molecular biology, biochemistry, cell biology, bioengineering

Tools

Liquid-handling automation

Automation platforms

qPCR machines

dPCR instruments

iPSC-derived cell culture tools

Job description

We think differently, act boldly, and push boundaries in pursuit of new heights. We’re building a team of scientists and drug developers committed to translating the field of upregulation into transformative medicines.

The journey is exhilarating. The view from the top is breathtaking. Join us at the forefront.

Mission

Pioneering a new approach to upregulate genes

Vision

To change the lives of countless patients with diseases caused by inadequate gene expression

CAMP4 Virtues

Be Bold

Push boundaries and pursue breakthroughs.

Be Agile

Adapt quickly to challenges and opportunities.

Be Curious

Turn curiosity into trailblazing science.

Be Inclusive

Lead with empathy and embrace diverse perspectives.

Act urgently. Patients are waiting.

Open Positions

If you want to be part of a company that is growing, nimble, and intent on changing the world, join the adventure that is CAMP4!

CAMP4 values the strength that diversity brings to the workplace. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other characteristic protected by applicable law.

Position:Research Associate II, High-Throughput Screening

Location: Cambridge, MA

Job Id:314

# of Openings:1

Position Title:Research Associate II, High-Throughput Screening
Reports To:Director, Platform
Location:Watertown, MA

Join the adventure!
CAMP4 Therapeutics is leveraging a proprietary RAP® platform to discover antisense oligonucleotide (ASO) therapeutics targeting regulatory RNAs (regRNAs) to treat a broad range of CNS diseases. We are seeking a motivated Research Associate II to join our high-throughput screening team to help identify, characterize, and optimize novel ASO therapeutics.

The successful candidate will execute, optimize, and automate existing in vitro screening workflows, culture relevant cell models, generate high-quality molecular data, and collaborate with Discovery, Chemistry, and Data Science colleagues. This role is ideal for a hands-on scientist who combines careful experimental execution with strong organization, curiosity, creativity, and teamwork.

Key Responsibilities:

• Plan and execute high-throughput in vitro screens supporting Platform and Discovery efforts to identify ASO candidates that modulate expression of disease-relevant genes
• Operate liquid-handling platforms and associated laboratory automation with a strong focus on accuracy, reproducibility, and throughput
• Culture, maintain, and experimentally manipulate immortalized, primary, and iPSC-derived cell models
• Perform molecular assays, including RNA isolation, quantitative PCR, digital PCR (dPCR), and protein-based readouts
• Analyze screening data, assess assay quality, identify trends, and communicate results to cross-functional project teams
• Develop, optimize, qualify, troubleshoot, and transfer screening assays, workflows, protocols, and data quality controls to drive improvements in efficiency and capabilities
• Collaborate with Platform, Discovery, Chemistry, and Data Science teams to manage screening priorities and advance hits through validation and characterization
• Maintain detailed and accurate records of experimental designs and results, protocols, sample inventories, and data files
• Support routine laboratory operations, including reagent and supply ordering and preparation, equipment maintenance, and general laboratory upkeep
• Demonstrate a strong work ethic by taking initiative, operating with urgency, and collaborating effectively to advance the discovery of breakthrough medicines for patients

Qualifications:
Education & Experience

• BS or MS degree in molecular biology, biochemistry, cell biology, bioengineering, or related discipline
• Relevant research experience in an industry or academic setting (3+ years with BS degree or 1+ year with MS degree); biotechnology or pharmaceutical industry experience is preferred
• Extensive hands-on experience with mammalian cell culture and cell-based assays
• Experience with basic molecular biology techniques including RNA isolation, quantitative PCR, and western blotting
• Demonstrated ability to execute experiments carefully, document work thoroughly, and deliver reproducible results
• Experience with liquid-handling automation and high-throughput screening is strongly preferred
• Experience with primary cells, differentiated iPSC-derived cells, dPCR, and ASOs, or other oligonucleotide therapeutics is a plus
• Experience with functional genomics or CRISPR-based screening is a plus
• Working proficiency with Microsoft Office, GraphPad, R, or a similar software
• Flexibility and comfort wearing multiple hats and executing on multiple projects in parallel
• Attention to detail, high professional integrity, commitment to excellence in execution, and capability of managing tasks and projects independently
• Clear written and verbal communication skills and the ability to present data to multidisciplinary audiences
• Collaborative, creative, adaptable, and self-motivated, with a commitment to scientific rigor and high-quality execution

Compensation and Benefits:
At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $85,000 - $110,000. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.

Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.

About CAMP4:
CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4’s proprietary RAPTM Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues. Learn more about us at www.camp4tx.com and follow us @CAMP4tx.