Research Associate I/II, Formulation Development

Arcturus Therapeutics Inc; San Diego (CA); Hybrid; USD 47,000 - 72,000; Full time

Benefits offered by this job

Free snacks and beverages

On campus gym

Company sponsored events

Job summary

Arcturus Therapeutics Holdings Inc. is hiring a temporary Research Associate I/II for Formulation Development in San Diego, CA. You will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations for multiple programs.

The role emphasizes learning, collaboration, and contributing to formulation production, with a focus on developing and validating processes for large-scale drug product production.

Qualifications

• Bachelor's or Master’s degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related science field.
• 2+ years of formulation development experience in life sciences or pharma settings.
• Experience with nucleic acid or lipid nanoparticle formulations is a major plus.

Responsibilities

• Develop nucleic acid formulations including complex nanoparticle formulations for in vitro and in vivo studies.
• Conduct process development of mRNA-LNP drug product for large-scale production.
• Investigate processes, identify root causes, evaluate trends, and ensure robustness.
• Perform stability studies and compatibility assessments for formulations.
• Maintain documentation and batch records, SOPs, and related manufacturing docs.
• Prepare technical reports and presentations summarizing results.
• Deliver high-quality results in a timely manner.

Skills

Nucleic acid formulations

Lipid nanoparticle formulations

Dynamic light scattering

Tangential Flow Filtration (TFF)

Fill/finish processes

Documentation & record-keeping

Attention to detail

Team collaboration

Education

Bachelor's or Master's in Chemistry/ pharma sciences/ related field

Tools

Dynamic Light Scattering

Tangential Flow Filtration (TFF)

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

Research Associate I/II, Formulation Development

Temporary San Diego, CA San Diego, CA, US

Salary Range: $34.00 To $52.39 Hourly

WHY WORK FOR ARCTURUS?

Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a global, late-stage clinical mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology (samRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat ornithine transcarbamylase (OTC) deficiency, and cystic fibrosis, along with partnered programs including glycogen storage disease type III, and hepatitis B virus. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus’ technologies are covered by its extensive patent portfolio (patents and patent applications issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations including, amongst others, Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., and the Cystic Fibrosis Foundation.

Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.

THE OPPORTUNITY

We are seeking a temporary Research Associate I/II to join our Formulation Team at our Headquarters in San Diego, CA.

In this role, you will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations to support our emerging research pipeline. Our ideal candidate will bring a willingness to learn and contribute to our formulation production and purification processes.

WHAT YOU WILL CONTRIBUTE

• Develop nucleic based formulations including complex nanoparticle formulations to support in vitro and in vivo studies for different programs.
• Conduct process development of mRNA-LNP drug product to enable successful production of large-scale drug product in internal and external manufacturing sites.
• Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness.
• Perform formulation stability studies, contact material compatibility, in-use compatibility study, and accelerated stability studies.
• Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentations.
• Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
• Deliver high quality results in an accurate and a time sensitive manner
• Perform other activities as needed.

WHAT WE SEEK

• 2+ years of relevant formulation development experience in a life science, pharmaceutical company, or academic lab setting. Experience with nucleic acid-based and/or lipid nanoparticle formulation development is a major plus.
• Hands on experience working with liquid, frozen, and/or lyophilized dosage forms and related biophysical and chemical analytical methods such as dynamic light scattering.
• Experience with TFF (Tangential Flow Filtration), dead-end filtration, and/or fill/finish is a plus.
• Record experiments and results in laboratory notebooks (including all electronic systems) in accordance with lab procedures in sufficient detail that co-worker can repeat experiment and interpret results in a timely manner
• Attention to details, ability to think ahead and strong communication skills
• Self-motivated team player excels in a highly innovative, collaborative, and fast-paced environment.

EDUCATION

• Bachelor's or Master’s degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related science field

WHAT WE OFFER

• Free variety of snacks and beverages
• On Campus Gym
• Company sponsored FUN events

The anticipated hourly rate for candidates who will work in San Diego is

RA I $34-$45

RA II $39- $52.39

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Arcturus Therapeutics is multi state employer and this salary range may not reflect positions that work in other states. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.

Arcturus is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.