Research Associate - Host-Pathogen Interactions

Isac Net; San Antonio (TX); Hybrid; USD 55,000 - 85,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

Life insurance

Retirement plan

Paid time off

Holidays

Job summary

Texas Biomedical Research Institute in San Antonio, TX is seeking a Research Associate to support NIH-funded host-pathogen research using the SIV rhesus macaque model. You will assist with sample processing, molecular analyses, and data management within a multidisciplinary team.

The role emphasizes RNA/DNA extraction, tissue embedding for spatial transcriptomics, cell isolation, flow cytometry, and sequencing prep, along with biosafety, documentation, and collaborative project support.

Qualifications

• Bachelor's degree in biology-related field required.
• Master's degree preferred for advanced roles.
• Experience with immunology and molecular biology techniques is expected.

Responsibilities

• Prepare blood and tissue samples for nucleic acid extraction (DNA, RNA, miRNA, lncRNA).
• Perform total RNA extraction for gene expression and sequencing studies.
• Process and embed tissues for spatial transcriptomics and imaging.
• Isolate and prepare various primary cell populations.
• Extract DNA and RNA from tissues and blood for downstream analyses.
• Prepare samples for spatial transcriptomics, ATAC-seq, single-cell applications.
• Perform multicolor flow cytometry staining and analysis.
• Prepare cell suspensions for FACS.
• Conduct molecular biology assays (RT-qPCR, in situ, immunofluorescence, Western blot).
• Assist with neurobehavioral testing in rhesus macaques and data analysis.
• Process, bank, and archive biospecimens in freezers; maintain inventories.
• Monitor equipment and ensure biosafety and regulatory compliance.
• Assist with IACUC documentation and PET/MRI imaging coordination.

Skills

Detail-oriented

Immunology techniques

Molecular biology

Flow cytometry

Data management

Documentation

Team collaboration

MS Office

Education

Bachelor's degree in Biology, Microbiology, Immunology, Molecular Biology, Biomedical Sciences

Master's degree preferred

Tools

Flow cytometer

qPCR

Bioanalyzer

PCR

LIMS

Job description

We are seeking a detail-oriented and highly motivated Research Associate to support innovative research focused on host-pathogen interactions using the simian immunodeficiency virus (SIV) rhesus macaque model. In this role, you will provide critical laboratory and data management support for multiple NIH-funded HIV/AIDS research projects investigating viral persistence, immune responses, transcriptomic, metabolomic and epigenetic changes and neurocognitive disease.

The successful candidate will prepare and process blood and tissue samples for molecular and cellular analyses, perform a wide range of immunology and molecular biology techniques, maintain valuable biorepositories, and collaborate closely with a multidisciplinary research team.

THE ROLE:

• Prepare blood and tissue samples for nucleic acid extraction, including DNA, total RNA, microRNA, and long non-coding RNA (lncRNA) analyses.
• Perform total RNA extraction for gene expression, DNA methylation, and microRNA studies.
• Process and embed tissues (including intestine, lymph nodes, adipose tissue, and brain) in OCT for spatial transcriptomics and other advanced imaging applications.
• Isolate and prepare epithelial cells, lamina propria cells, lymph node cells, adipose tissue cells, PBMCs, microglia, astrocytes, and other primary cell populations.
• Extract DNA and RNA from tissues and blood samples for downstream molecular analyses.
• Prepare samples for spatial transcriptomics, ATAC-sequencing, single-cell applications, and other next-generation sequencing technologies.
• Perform multicolor flow cytometry staining, acquisition, and analysis on blood and tissue-derived cell populations.
• Prepare cell suspensions for fluorescence-activated cell sorting (FACS).
• Conduct molecular biology assays, including real-time RT-qPCR, combined in situ hybridization and immunofluorescence, immunoprecipitation and Western blotting, luciferase reporter assays, and molecular biology techniques such as molecular cloning, plasmid preparation, bacterial culture, and cell transfection.
• Assist with neurobehavioral testing of rhesus macaques using CANTAB and Wisconsin General Testing Apparatus (WGTA) systems, including data collection and analysis.
• Process, bank, and archive plasma, tissues, and cellular specimens in liquid nitrogen and ultra-low temperature freezers.
• Maintain laboratory databases, frozen sample inventories, and biorepository records.
• Monitor laboratory equipment and freezer conditions to ensure sample integrity.
• Order laboratory supplies, maintain inventory, and ensure laboratory organization, safety, and compliance.
• Assist with shipping and receiving infectious and noninfectious biological materials in accordance with institutional and regulatory requirements.
• Prepare stock solutions, controlled substances, and antiretroviral medications for Veterinary Medicine.
• Assist with the preparation and maintenance of IACUC protocols and other laboratory regulatory documentation.
• Assist with coordinating PET/CT imaging (internal) and magnetic resonance imaging (Mobile MRI services- external) of rhesus macaques.

OUR IDEAL CANDIDATE:

The ideal candidate is passionate about biomedical research, enjoys working in a collaborative laboratory environment, and has exceptional organizational and technical skills.

Education

• Bachelor's degree in Biology, Microbiology, Immunology, Molecular Biology, Biomedical Sciences, or a related field required.
• Master's degree in a related scientific discipline preferred.

Experience

• Four (4) years of relevant laboratory experience with a bachelor's degree, or
• Two (2) years of relevant laboratory experience with a master's degree.

Preferred Qualifications

Experience with one or more of the following is highly desirable:

• Molecular biology techniques, including DNA/RNA extraction, PCR, cloning, and gene expression analysis
• Cell and tissue culture using aseptic techniques
• Flow cytometry and fluorescence-activated cell sorting (FACS)
• Ficoll separation of blood components
• Immunofluorescence, Western blotting, and microscopy
• Tissue processing and biobanking
• Next-generation sequencing sample preparation (e.g., ATAC-seq, spatial transcriptomics, single-cell technologies)
• Laboratory information management and sample tracking systems

Knowledge, Skills & Abilities

• Strong attention to detail and excellent laboratory technique.
• Ability to safely handle infectious agents, blood, biohazardous tissues, and laboratory chemicals while following established biosafety procedures.
• Excellent organizational, time management, and documentation skills.
• Strong written and verbal communication skills with the ability to work effectively both independently and within a collaborative research team.
• Proficiency with Microsoft Office and standard scientific software applications.
• Commitment to maintaining laboratory safety, quality standards, and scientific integrity.

WHAT WE CAN OFFER YOU:

• Enjoy an employee-centered culture grounded in open communication, empowerment, and trust. We believe in working hard and having fun, offering 100+ culture events each year to bring our team together and keep the energy strong!
• Comprehensive health, dental, vision, and life insurance coverage for you and your family—including pet insurance options.
• Competitive employer-funded retirement plan with 6% contributions starting on day one, increasing with years of service.
• Generous paid time off, including 14 paid holidays and a paid Winter Recess (from the last week of December through New Year's).
• Paid time off for short-term illness and mental wellness, helping you take the time you need when life happens.
• Volunteer Time Off (VTO) to encourage giving back to the community.
• Paid parental leave to support you and your growing family.
• Flexible work arrangements that support a strong work-life balance.
• On-site medical clinic, wellness incentives, and prescription support programs designed to make care more accessible and affordable.
• On-site fitness center and wellness programs to help you stay active and healthy.
• Relaxed dress code so you can feel comfortable and be yourself at work.
• Dynamic learning environment with professional development opportunities, mentorship, tuition reimbursement, and leadership programs to support your growth.
• Proud recipient of the 2025 Healthy Workplace Platinum Recognition from the San Antonio Business Group on Health (SABGH)—the highest honor for employee-focused wellness initiatives.

WHO WE ARE:

• Texas Biomedical Research Institute is one of the world's leading independent biomedical research institutions dedicated to advancing global human health through innovative biomedical research. Texas Biomed aims to unravel the mysteries of infectious diseases through innovative thinking, creative problem solving and cutting-edge technologies.
• Texas Biomed is the only independent, nonprofit infectious disease research institute in the U.S. to combine:
• The highest-level biocontainment labs for infectious disease and biodefense research
• A federally-designated National Primate Research Center
• More than 80 years of discoveries advancing diagnostics, vaccines and therapies
• An entrepreneurial culture and specialized expertise in regulated science required for FDA approval

We take pride in fostering a culture of respect, opportunity, and unity! Texas Biomedical Research Institute provides equal employment opportunities for all qualified employees and applicants without regard to race, color, sex, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.