Research Associate - Electrophysiology

Baylor College of Medicine; Houston (TX); On-site; USD 65,000 - 70,000; Full time

Job summary

The Baylor College of Medicine St-Pierre lab is seeking a Research Associate to lead electrophysiology and optical imaging efforts. You will work with genetically encoded voltage indicators and optogenetic silencers, combining multi-photon recordings with optical excitation in vitro and in vivo.

The role requires hands-on experience with brain slices or dissociated neurons, maintaining a rig, and data analysis. This onsite position offers collaboration and advancement in brain imaging techniques.

Qualifications

• Experience performing electrophysiology in dissociated neurons, brain slices or both.
• Experience dissecting rat cortical/hippocampal neurons.
• Maintaining an electrophysiology rig.

Responsibilities

• Prepare brain slices or dissociated neurons for experiments.
• Conduct electrophysiology with optogenetic activation or optical imaging.
• Maintain reagents, tools, and an electrophysiology rig.
• Analyze data with commercial software or custom pipelines.
• Teach techniques and experimental design to lab members.
• Communicate results in meetings and conferences.
• Plan, direct and conduct experiments; document results.

Skills

Electrophysiology data analysis

Brain slice preparation

Scientific communication

Education

Master's degree in Basic Science or related field

Tools

Electrophysiology rig

Two-photon imaging setup

Job description

Job Title: Research Associate - Electrophysiology

Work Arrangement: Onsite only

Location: Houston, TX

Salary Range: $65,000- $70,000

FLSA Status: Exempt

Work Schedule: Monday – Friday, 8 a.m. – 5 p.m.

Summary

The St-Pierre lab develops and applies new tools for monitoring and interrogating brain activity with millisecond-timescale temporal resolution. We seek an energetic team member to lead our efforts to characterize and apply new light-responsive proteins in vitro and in vivo. The Research Associate will work on two types of tools: (1) genetically encoded voltage indicators (GEVIs), fluorescent biosensors that report voltage as changes in brightness, and (2) optogenetic silencers, light-gated channels that inhibit neuronal firing. Characterization of these tools requires simultaneous electrophysiological recordings and optical excitation/imaging. This position provides exciting opportunities to work with the latest optical technologies and develop new skills in two-photon voltage

Job Duties

• Prepare brain slices, dissociated neurons, or both
• Conduct experiments that combine electrophysiology and either optogenetic activation or optical imaging (multi-photon fluorescence microscopy)
• Maintain reagent and tool supply related to the experiments
• Maintain an electrophysiological rig, and troubleshooting if needed
• Analyze data using commercial software or customized data pipelines
• Teach techniques, procedures, and experimental design to other members of the lab
• Communicate research results in group meetings, national or international conferences
• Plan, direct and conduct research experiments
• Evaluate and analyze data
• Develop research techniques and perform applications required for specific research projects
• May conduct literature searches and summarize information in an appropriate format for a particular study
• Document results of experiments and report to principal investigators
• May supervise, schedule and coordinate the activities of less experienced research staff
• Perform other job related duties as assigned

Minimum Qualifications

• Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
• Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Department Specific Criteria

• Must have experience with performingelectrophysiology indissociated neurons, brain slices or both
• Must have experience with dissecting rat cortical, hippocampal neurons, or both
• Must have experience maintaining an electrophysiology rig

Preferred Qualifications

• Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation
• Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging

Work Authorization Requirement:

This position is not eligible for visa sponsorship.Candidates must be legally authorized to work in the United States at the time of application and throughout the duration of employment.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.