Remote Senior Manager, Clinical Operations & Strategy

Lycia Therapeutics, Inc.; South San Francisco (CA); Remote; USD 169,000 - 250,000; Full time

Job summary

Lycia Therapeutics, Inc. is seeking an experienced Clinical Operations leader to create and execute strategic plans for clinical programs, aligning resources with product strategy and ensuring timely delivery.

You will oversee outsourcing, vendor relationships, budgeting, SOPs and regulatory compliance (FDA/ICH-GCP), build a high‑performing team, and travel as needed for trials; this remote role offers flexibility while collaborating with our South San Francisco HQ.

Qualifications

• Bachelor's degree required; advanced degrees preferred.
• Minimum 7 years in clinical operations for manager, 12+ years for director.
• Strong leadership, collaboration, and strategic thinking.
• Ability to influence across functions in a global setting.

Responsibilities

• Create and execute clinical operational strategic plans aligned with product strategy and resources.
• Develop study feasibility, cost estimates, and support outsourcing contracts and changes.
• Track study finances, accruals, and vendor invoices.
• Build and train internal staff and external vendors to improve efficiency.
• Develop and ensure SOPs, FDA regulations and ICH-GCP compliance.
• Oversee CROs, vendors, and investigative sites.
• Participate in clinical operations and study team meetings.
• Maintain up-to-date knowledge of clinical literature and regulatory practice.

Skills

Clinical operations leadership

Budgeting & forecasting

Vendor management

Cross-functional collaboration

Regulatory compliance (FDA/ICH-GCP)

Education

B.A./B.S. required

MS/PhD/PharmD/MD strongly preferred

Job description

Lycia Therapeutics is a biotechnology company using its proprietary lysosomal targeting chimera (LYTAC) platform to discover and develop best-in-class therapeutics that degrade extracellular and membrane-bound proteins. These proteins drive a wide range of difficult-to-treat diseases, including autoimmune and inflammatory conditions. Lycia was established in 2019 in collaboration with academic founder and Nobel Laureate Carolyn Bertozzi, Ph.D., professor of chemistry and HHMI investigator at Stanford University. In June, 2026, Lycia Therapeutics completed a $75 million Series D financing to advance its pipeline of LYTAC extracellular protein degraders into the clinic. Lycia is headquartered in South San Francisco.

Visit https://lyciatx.com/ for more information.

Position Summary

The Senior Manager/Director Clinical Operations will be responsible for oversight and management of up to 2 early phase clinical programs in collaboration with the selected Clinical Research Organization (CRO).

Primary Responsibilities:

• Create and execute clinical operational strategic plans in line with product strategy and resource allocation.
• Develop study feasibility, cost estimates, input into contracts, work/change orders and analyze tools and processes to support outsourcing efforts.
• Track clinical program study finances and monthly accruals and review/approve associated clinical site and vendor invoices.
• Build, develop and train internal staff and external vendors, structure department for enhancing efficiency, and create a highly engaged work environment for attracting and retaining highly qualified clinical operations professionals.
• Develop and ensure compliance with SOPs and guidelines, FDA regulations and current ICH GCP guidelines.
• Oversee and maintain the relationships with Contract Research Organizations, vendors, and investigative sites.
• Participate on clinical operations and study team meetings.
• Maintain a high level of professional expertise through familiarity of clinical literature, knowledge of therapeutic area, current medical practice and pharmaceutical regulations.

Additional Expectations

• Although a remote position, it may be necessary to travel to corporate headquarters up to 2 times per year.
• Ability to travel to clinical sites or to the CRO, as necessary to support trial management.

Qualifications:

• B.A/B.S required; M.S., PhD, PharmD, MD or other related advanced scientific degree strongly preferred.
• Minimum of 7 years for manager and 12 years for director level with progressive advancement within clinical operations in the pharmaceutical/biotech industry.
• Flexible and dynamic interpersonal approach, entrepreneurial by nature, a collaborative team player who works well with physicians, scientists, managers, peers, and staff.
• Ability to manage in a consensus environment through teamwork, trust and shared expectations, influencing strategic direction of complex global clinical operations issues, solicit information, listen well, persuade others, make important decisions and shape outcomes.

$175,000 - $202,000 a year

The salary range for this position are $175,000-202,000, which reflects the range across all US locations for which we are hiring. Actual salary will depend on the candidate's geographic location, along with experience, skills, and qualifications.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Lycia and other biotech companies have recently noticed an increase in email and social media scams targeting job candidates in our industry. Please note Lycia will post any legitimate job openings directly on our website or through our recruitment partner, Lever. If you wish to verify the legitimacy of a job opening, you may contact us.