Remote Senior Manager, Clinical Data Enablement

Takeda; Boston (MA); On-site; USD 137,000 - 215,000; Full time

Job summary

Takeda in MA (Virtual) is seeking a Senior Manager, Clinical Data Enablement to lead end-to-end clinical data pipelines across lake/warehouse environments and drive cloud-based ETL/ELT capabilities. You will collaborate with cross-functional teams, vendors, and downstream groups to deliver compliant, high-quality data products on time.

The role requires 6+ years in data engineering, strong SQL/Python skills, and experience with CDISC standards.

Qualifications

• BS/BA (or equivalent) plus 6+ years in data engineering and multi-source data integration.
• Strong SQL, data modeling, and data quality controls; working knowledge of NoSQL.
• Proficiency in Python; experience building production pipelines; familiarity with SDLC; Jira/Confluence required.
• Knowledge of CDISC, CDASH, and SDTM standards preferred.
• Hands-on with CSV, JSON, XML, and API/file-based integrations.

Responsibilities

• Own end-to-end clinical data pipelines across lake/warehouse environments (build, run, monitor, maintain, troubleshoot) to ensure stable, performant, traceable operations.
• Drive operational excellence through monitoring/alerting, incident management, root-cause analysis, and corrective/preventive actions.
• Build and scale cloud ETL/ELT capabilities (AWS/Azure) for efficient ingestion, transformation, orchestration, and delivery.
• Automate integrations and run operations (scheduling, metadata-driven pipelines, automated quality checks) to improve reliability and timeliness.
• Partner with vendors and cross-functional teams to define data transfer specifications, acceptance criteria, and integration patterns; implement integrations with robust error handling and reconciliation.
• Serve as an SME for structured and unstructured data integration, driving continuous improvements through stakeholder feedback and evolving requirements.
• Partner with downstream teams (Stat Programming, SDTM, Analytics, Clinical Data Programming) to deliver fit-for-purpose datasets and interfaces (format, structure, cadence).
• Ensure on-time, high-quality delivery to agreed specifications; establish and manage SLAs/OLAs as needed.
• Design and deliver GxP-aligned clinical data engineering solutions with lifecycle documentation, traceability, and audit-ready evidence.
• Embed data integrity controls (e.g., ALCOA+) and support validated operations via change control, incident/deviation documentation, periodic review, and inspection readiness.
• Collaborate with Quality/Compliance/IT to implement appropriate access controls, logging/audit trails (as applicable), and operating controls.

Skills

SQL

Python

Mentoring

Communication

Problem-solving

Education

BS/BA (or equivalent)

Tools

GitHub/GitLab

Jira/Confluence

CI/CD

Snowflake

Databricks

AWS

Azure

Job description

Takeda in MA (Virtual) is seeking a Senior Manager, Clinical Data Enablement to lead end-to-end clinical data pipelines across lake/warehouse environments and drive cloud-based ETL/ELT capabilities. You will collaborate with cross-functional teams, vendors, and downstream groups to deliver compliant, high-quality data products on time.

The role requires 6+ years in data engineering, strong SQL/Python skills, and experience with CDISC standards.