Remote Principal Scientist, Drug Substance Chemistry

Praxis Precision Medicines, Inc.; Boston (MA); On-site; USD 165,000 - 185,000; Full time

Benefits offered by this job

Bonus potential

401(k) with company match

Stock incentives

Job summary

Praxis Precision Medicines, Inc. seeks a Principal Scientist in Process Chemistry to lead drug substance activities across clinical and commercial supply.

This role drives design of robust processes for small molecule APIs and collaborates with CMC and project teams under Agile management to deliver data packages for regulatory submissions. You will oversee demonstrations from lab to pilot plant, coordinate with CROs/CDMOs, manage budgets, and contribute to IP strategy while maintaining focus on

Qualifications

• Advanced degree or commensurate experience in Organic Chemistry, Pharmaceutical Sciences, Engineering or related discipline.
• Minimum of 5+ years of industry experience in CMC for small molecule drug substance.
• Experience with salt/crystalline form selection and oligonucleotide chemistry is a plus.

Responsibilities

• Lead Process Chemistry R&D for one or more projects from early to late phase.
• Design early and late/ commercial drug substance processes and scale from lab to pilot plant.
• Provide chemistry and technical leadership throughout the lifecycle.
• Collaborate with formulations, analytical, operations, engineering and quality as part of the CMC team.
• Identify external CRO/CMO partners to achieve deliverables and manage budgets.

Skills

Small molecule CMC

Continuous processing

Catalysis/Biocatalysis

Regulatory submissions

Cross-functional leadership

Analytical oversight

Education

Advanced degree in Organic Chemistry / Pharmaceutical Sciences / Engineering

Job description

Praxis Precision Medicines, Inc. seeks a Principal Scientist in Process Chemistry to lead drug substance activities across clinical and commercial supply.

This role drives design of robust processes for small molecule APIs and collaborates with CMC and project teams under Agile management to deliver data packages for regulatory submissions. You will oversee demonstrations from lab to pilot plant, coordinate with CROs/CDMOs, manage budgets, and contribute to IP strategy while maintaining focus on