RA-Sr. RA - Cell Culture/Cell Line Development

Prellis Biologics; Berkeley (CA); Hybrid; USD 90,000 - 120,000; Full time

Benefits offered by this job

Group medical, dental, and vision

Life and disability insurance

401(k) plan

Holiday package including a 1+ week冬季休

Job summary

Prellis Biologics in Berkeley, CA is seeking a Senior Research Associate, Cell Culture/Cell Line Development, to maintain, scale, and develop mammalian cell lines for biologics discovery. The role involves hands-on laboratory work, data analysis, and collaboration with cross-functional teams to advance antibody screening.

You will perform aseptic culture across CHO and HEK293 lines, support transfection and clone screening, and contribute to in vitro assays.

Qualifications

• B.S. in molecular biology, chemistry, immunology, biotechnology, or related life science field.
• 2+ years of relevant laboratory experience.
• 1-2 years hands-on mammalian cell culture experience, industry preferred.
• Familiarity with cell line development techniques (stable and transient transfection, clone selection, characterization).
• Strong organizational and time-management skills.
• Ability to work independently and in a collaborative team.
• Experience with small-scale bioreactor systems is a plus.

Responsibilities

• Perform aseptic mammalian cell culture across multiple cell lines in parallel (e.g., CHO, HEK293).
• Maintain, passage, expansion, and cryopreservation of cell lines to ensure a reliable supply of high-quality cells for downstream applications.
• Support cell line development workflows, including transfection, clone screening, and selection.
• Contribute to cell-based in vitro assay execution to support antibody screening and downstream characterization efforts.
• Maintain meticulous experimental records and effectively communicate findings in internal meetings.
• Contribute to process optimization for improved productivity and product quality.

Skills

Mammalian cell culture

Aseptic technique

Transfection/clone screening

Data analysis

Independent / collaborative work

Education

B.S. in Molecular Biology, Chemistry, Immunology, Biotechnology, or related life science field

Tools

Small-scale bioreactor systems

Job description

Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and in vitro human lymph node cocultures for generating antigen-specific B-cells. We are seeking a highly motivated Research Associate - Senior Research Associate, Cell Culture/Cell Line Development, to join our Antibody Screening team. The successful candidate will contribute to the maintenance, scale-up, and development of mammalian cell lines for biologics discovery. This role will involve hands‑on laboratory work, data analysis, and close collaboration with cross-functional teams.

Key Responsibilities:

• Perform aseptic mammalian cell culture across multiple cell lines in parallel (e.g., CHO, HEK293, etc.)
• Support routine maintenance, passaging, expansion, and cryopreservation of cell lines to ensure a reliable supply of high-quality cells for downstream applications
• Support cell line development workflows, including transfection, clone screening, and selection
• Contribute to cell based in vitro assay execution to support antibody screening and downstream characterization efforts
• Maintain meticulous experimental records and effectively communicate findings in internal meetings
• Contribute to process optimization for improved productivity and product quality

Minimum Qualifications:

• B.S in Molecular Biology, Chemistry, Immunology, Biotechnology, or related life science field with 2+ years of relevant experience.
• 1-2 years of hands‑on laboratory experience in mammalian cell culture is required (industry setting preferred). Demonstrated proficiency with aseptic technique.
• Familiarity with cell line development techniques (stable and transient transfection, clone selection, characterization, etc.).
• Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment.
• Ability to work independently and as part of a collaborative team.
• Experience with small-scale bioreactor systems is a strong plus.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system with tightly integrated machine learning to develop next‑generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human antibody candidates rapidly identified from the human immune repertoire, enabling them to bring life‑changing treatments to patients faster than ever before. Prellis Biologics is a pre‑IPO biotech located in Berkeley, CA with a team‑oriented, inclusive, and family‑friendly culture. Our growing pipeline targets high unmet patient needs across therapeutic areas including metabolic disease, inflammation, and oncology. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, and Avidity Partners.

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

Actual salary will vary based on several factors including, but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save toward retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental, and vision coverage, life and disability insurance, flexible spending accounts, and a 401(k) plan
• Stock-based long-term incentives
• Holiday package including a 1+ week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application Deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams - grounded in a wide range of expertise and life experiences - and work even harder to ensure those teams thrive in inclusive, growth‑oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.