RA / Associate Scientist, Oligo & Peptide Chemistry

Nosis Bio; Alameda (CA); On-site; USD 60,000 - 100,000; Full time

Job summary

Join a pioneering biotech startup focused on revolutionizing RNA therapeutics. In this dynamic role, you'll leverage your expertise in peptide and oligonucleotide chemistry to drive innovative drug discovery projects. Collaborate with a diverse team of scientists in a cutting-edge lab environment, where your contributions will directly impact the future of therapeutic development. If you're passionate about science and eager to tackle complex challenges, this opportunity is perfect for you. Be part of a mission to address unmet medical needs and help shape the future of healthcare.

Qualifications

• Hands-on experience with peptide and oligonucleotide chemistry.
• Experience with automated synthesizers and HPLC purification.

Responsibilities

• Conduct chemical synthesis and chromatographic purification of proteins.
• Perform oligonucleotide synthesis and HPLC purification of products.

Skills

Peptide Chemistry

Oligonucleotide Chemistry

HPLC Purification

Mass Spectrometry Analysis

Automated Peptide Synthesizers

Problem Solving

Multitasking

Education

Bachelor's Degree

Master's Degree

Tools

Liberty Prime Synthesizer

MultiPep Synthesizer

MerMade 12 Synthesizer

Job description

Alameda, CA

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Nosis Bio is a well-funded biotech startup exclusively focused on developing cell-specific RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts that believe targeted extrahepatic delivery is the only thing preventing RNA therapies from becoming the standard-of-care for most chronic diseases. We combine deep expertise in receptor biology, generative AI, and high throughput in vivo data generation to exponentially accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech.

About Nosis Bio:

Nosis Bio is a well-funded biotech startup exclusively focused on developing cell-specific RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts that believe targeted extrahepatic delivery is the only thing preventing RNA therapies from becoming the standard-of-care for most chronic diseases. We combine deep expertise in receptor biology, generative AI, and high throughput in vivo data generation to exponentially accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech.

About the Role:

We are seeking a RA / Sr. RA / Assoc. Scientist to conduct chemical synthesis and chromatographic purification of proteins, peptides, and oligonucleotides to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) properties of therapeutic candidates. The successful candidate will have hands-on experience with peptide and/or oligo chemistry and will work closely with multidisciplinary teams to support various drug discovery projects.

Responsibilities:

1. Perform peptide synthesis on Liberty Prime and MultiPep synthesizer
2. Perform oligonucleotide synthesis on MerMade 12 synthesizer
3. Perform conjugations of oligonucleotides and peptides to various chemical tags (biotin, fluorescent dyes, etc.)
4. Perform HPLC purification and MS analysis of synthesized products
5. Maintenance of chemistry instruments

What we’re looking for:

• Direct hands-on experience with automated peptide synthesizers (Liberty Prime, MultiPep or similar instruments)
• Experience with automated oligo synthesizers a plus
• Motivated and proactive with strong problem-solving skills
• Ability to multitask and manage several projects simultaneously
• Team-oriented and open to collaboration across scientific disciplines
• Ability to work on site in our lab space located in the Research Park at Marina Village (Alameda)
• Title is dependent on academic and professional experience – we recruit diverse backgrounds including those with academic, non-profit, and industry experiences!
• RA / Senior RA – Undergraduate and 2+ yrs industry (or similar) experience
• Assoc. Scientist – Master’s degree and 0+ yrs experience OR undergraduate degree and 3+ yrs experience

Seniority level

• Entry level

Employment type

• Full-time

Job function

• Research, Analyst, and Information Technology

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