Quality Management System Lead

Tango Therapeutics; Boston (MA); On-site; USD 151,200 - 226,800; Full time

Job summary

Tango Therapeutics seeks a Quality Assurance leader to own and continuously improve the QMS framework across GMP/GLP/GCP domains. You will drive document control, training, and data integrity while ensuring compliance across functions and regions.

You will oversee change control, CAPA prevention, and audit readiness, partnering with cross-functional teams to define training requirements and governance. This role demands strong analytical and communication skills in a regulated, fast-paced

Qualifications

• Bachelor’s degree in Life Sciences, Quality, or related discipline (required).
• Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems).
• Training in electronic QMS platforms advantageous.
• 8–12 years in Quality Assurance or Compliance.
• Hands‑on experience managing QMS in regulated GxP environments.
• Experience supporting QMS‑related inspections and audits.
• QMS design, lifecycle management, and governance.
• GxP training systems and compliance tracking.
• Data integrity and document control standards.
• Process‑oriented, structured, and detail focused.
• Strong communication and training skills.
• Ability to simplify complex processes and drive alignment.

Responsibilities

• Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.
• Harmonize across GxP domains (GMP/GLP/GCP) and align with applicable regulations/standards.
• Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival).
• Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts).
• Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting).
• Partner with functional owners to define role-based training requirements.
• Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles.
• Establish metrics and trending for QMS health (cycle time, overdue items, training compliance).
• Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings.
• Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans.

Skills

QMS governance

GxP compliance

Training design

Data integrity

Document control

Cross-functional collaboration

Quality audits

CAPA management

Process optimization

Education

Bachelor’s degree in Life Sciences or Quality

Tools

Electronic QMS platforms

Job description

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.

Your Role:

• Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governance
• Ensure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standards
• Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival)
• Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts)
• Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting)
• Partner with functional owners to define role-based training requirements
• Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles
• Establish metrics and trending for QMS health (cycle time, overdue items, training compliance)
• Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings
• Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans

What You Bring:

• Bachelor’s degree in Life Sciences, Quality, or related discipline (required)
• Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems)
• Training in electronic QMS platformsadvantageous
• 8–12 years in Quality Assurance or Compliance
• Hands‑on experience managing QMS in regulated GxP environments
• Experience supporting QMS‑related inspections and audits
• QMS design, lifecycle management, and governance
• GxP training systems and compliance tracking
• Data integrity and document control standards
• Process‑oriented, structured, and detail focused
• Strong communication and training skills
• Ability to simplify complex processes and drive alignment

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$151,200 - $226,800 USD

Are you currently located in the Greater Boston area and able to commute to 201 Brookline Avenue, near Fenway Park, on a flexible/hybrid schedule?

Will you require employment sponsorship now or in the future?

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As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

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