Protein Modeling & Binder Design Scientist (Computational)

Kelly Science, Engineering, Technology & Telecom; Pasadena (CA); On-site; USD 120,000 - 175,000; Full time

Job summary

Kelly Science & Clinical is seeking a Computational Structural Bioinformatics Scientist for Protein Modeling & Binder Design in Pasadena, CA. This direct-hire, onsite role supports docking pose evaluation, experimental planning, and binder design against chosen epitopes.

Expect to work in a fast-paced team focused on computational workflows and reproducible results. The ideal candidate holds a PhD in a related field and has 5+ years in structural bioinformatics, docking, and binder design

Qualifications

• Ph.D. in bioinformatics, computational biology, structural biology, biophysics, computational chemistry or a related field preferred.
• 5+ years of experience with structural bioinformatics, protein–protein docking, and analysis of protein interfaces.
• 5+ years of experience developing or applying computational protein modeling or binder design workflows, including VHH, scFv, peptide, or modified AAV capsid formats.
• 5+ years programming experience for reproducible scientific workflows; familiarity with cloud environments such as GCP or AWS; ability to interpret experimental binding evidence and communicate modeling limitations.

Responsibilities

• Configure and implement a workflow for AAV capsid–receptor docking, incorporating relevant experimental binding evidence to evaluate and rank alternative poses.
• Develop a prioritized experimental plan for leading epitope hypotheses, including substitutions or constructs, controls, assay readouts, interpretation criteria.
• Develop and assess binder design workflows for VHH, scFv, peptide, and modified AAV capsid formats; rank pilot candidates for experimental testing and provide scale-up recommendations.

Skills

Structural bioinformatics

Protein docking

Binder design workflows

Cloud environments (GCP AWS)

Education

Ph.D. in bioinformatics / related field

Job description

Kelly Science & Clinical is seeking a Computational Structural Bioinformatics Scientist for Protein Modeling & Binder Design in Pasadena, CA. This direct-hire, onsite role supports docking pose evaluation, experimental planning, and binder design against chosen epitopes.

Expect to work in a fast-paced team focused on computational workflows and reproducible results. The ideal candidate holds a PhD in a related field and has 5+ years in structural bioinformatics, docking, and binder design