Protein Biochemistry Scientist – San Diego (On-site)

Element Biosciences Inc; San Diego (CA); On-site; USD 116,000 - 149,000; Full time

Benefits offered by this job

Stock options

Discretionary annual bonus

Health insurance plans

401k with company match

Flexible paid time off

Job summary

Element Biosciences is seeking an experienced Scientist, Biochemistry in San Diego to develop protein-based assays and optimize reagents for sequencing and multiomics workflows. You will design and interpret experiments on protein reagents and work with cross-functional teams in a fast-paced environment.

The role requires a PhD with 2+ years in industry and hands-on technique expertise, including SDS-PAGE, ELISA, and mass spectrometry.

Qualifications

• PhD in Biochemistry or related field with 2+ years of industry experience.
• Strong foundation in protein biochemistry and assay development.
• Experience developing, optimizing, and troubleshooting complex biological assays.
• Experience designing experiments and analyzing multidimensional datasets.
• Excellent communication and technical documentation skills.
• Experience working with recombinant proteins, antibodies, enzymes, or affinity reagents.
• Hands-on protein analytical techniques such as SDS-PAGE, western blotting, ELISA, UV-Vis spectroscopy, fluorescence-based assays, HPLC/FPLC, SEC, DLS, SPR, BLI, or mass spectrometry.
• Experience developing quantitative biochemical assays for research or commercial products.
• Familiarity with DOE methodologies and JMP/GraphPad Prism.
• Experience supporting regulated product development or technology transfer is desirable.
• Experience developing reagents or assays for genomics, sequencing, or multiomic applications is a plus.

Responsibilities

• Lead the development, optimization, and validation of protein-based assays supporting sequencing workflows.
• Design, execute, and interpret experiments focused on protein reagents, antibodies, enzymes, and other biologically derived reagents.
• Develop and optimize reagent formulations to improve assay performance, stability, robustness, and manufacturability.
• Design rigorous experiments using sound statistical principles to identify root causes and solve complex technical problems.
• Establish analytical methods for protein characterization, qualification, and quality assessment.
• Support technology transfer of assays and reagents from research into product development and manufacturing.
• Generate detailed experimental documentation, technical reports, protocols, and design recommendations.
• Drive troubleshooting efforts for challenging technical issues across multiple product development programs.
• Evaluate emerging technologies and literature to identify innovative solutions and opportunities.
• Collaborate cross-functionally with teams including chemistry, molecular biology, systems engineering, software, operations, manufacturing, quality, and product management.
• Mentor junior scientists and contribute technical expertise across multiple R&D projects.
• Present scientific findings to cross-functional teams and senior leadership.

Skills

Protein biochemistry

Assay development

Statistical analysis

DOE methods

Communication skills

Education

Ph.D. in Biochemistry or related field

Tools

SDS-PAGE

Western blotting

ELISA

HPLC

SEC

Mass spectrometry

JMP

GraphPad Prism

Job description

Element Biosciences is seeking an experienced Scientist, Biochemistry in San Diego to develop protein-based assays and optimize reagents for sequencing and multiomics workflows. You will design and interpret experiments on protein reagents and work with cross-functional teams in a fast-paced environment.

The role requires a PhD with 2+ years in industry and hands-on technique expertise, including SDS-PAGE, ELISA, and mass spectrometry.